Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryWe developed new iminosugar-based glycosidase inhibitors against SARS-CoV-2. Known drugs (miglustat, migalastat, miglitol, and swainsonine) were chosen as lead compounds to develop three classes of glycosidase inhibitors (α-glucosidase, α-galactosidase ...
Zorana Ferjancic +15 more
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Influence of Side Chain Conformation on the Activity of Glycosidase Inhibitors [PDF]
Angewandte Chemie - International Edition, 2023 Ande Chennaiah +2 more
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Iminosugars of the Invasive Arboreal Amorpha fruticosa and Glycosidase Inhibition Potential [PDF]
PlantsAmorpha fruticosa L. (Fabaceae) originates from North America and has become an aggressive invasive plant in many parts of the world. It affects the local biodiversity in many negative ways. Our previous in vivo tests of purified extract of A.
Robert J. Nash +3 more
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Frontiers in Chemistry, 2021 α-Glycosidase inhibitors could inhibit the digestion of carbohydrates into glucose and promote glucose conversion, which have been used for the treatment of type 2 diabetes.
Shan-Kui Liu +13 more
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Molecular Docking Analysis of Embelia ribes for Selected Constituents as Spodoptera frugiperda (Fall Armyworm) Beta Glycosidase and Caspase-1 Inhibitors [PDF]
Nature Environment and Pollution Technology, 2023 Insect pest control is one of the major issues facing the agriculture sector because of the need for new agrochemicals and biocontrol agents that are environmentally friendly, economically affordable, and safe for human health.
Srinivasan Kumaraswamy, Vasantha-Srinivasan Prabhakaran and Radhakrishnan Narayanaswamy
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Frontiers in Microbiology, 2022 α-Glucosidase and α-amylase are the two main glycosidases that participate in the metabolism of carbohydrates. Inhibitors of these two enzymes are considered an important medical treatment for carbohydrate uptake disorders, such as diabetes and obesity ...
Xiaojing Wang +16 more
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Molecules, 2021 Lytic transglycosylases such as Slt35 from E. coli are enzymes involved in bacterial cell wall remodelling and recycling, which represent potential targets for novel antibacterial agents. Here, we investigated a series of known glycosidase inhibitors for
Aysha B. Mezoughi +8 more
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Multivalent Pyrrolidine Iminosugars: Synthesis and Biological Relevance
Molecules, 2022 Recently, the strategy of multivalency has been widely employed to design glycosidase inhibitors, as glycomimetic clusters often induce marked enzyme inhibition relative to monovalent analogs.
Yali Wang +3 more
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Anticholinergic and antidiabetic effects of isoeugenol from clove (Eugenia caryophylata) oil
International Journal of Food Properties, 2019 Isoeugenol (2-methoxy-4-(prop-1-en-1-yl)phenol), a component of from clove (Eugenia caryophylata) oil, is a starting material for both the biotechnological and synthetic production of vanillin and vanillic acid.
Fevzi Topal
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Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers
Natural Products and Bioprospecting, 2022 Natural products have attracted the interest of the scientific community due to their importance and application. Alexine is a naturally polyhydroxylated pyrrolizidine alkaloid that is broadly found in plant sources and isolated from Alexa leiopetala ...
Ghodsi Mohammadi Ziarani +2 more
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