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Recent Advances in Electrochemical Biosensors Based on Enzyme Inhibition for Clinical and Pharmaceutical Applications

open access: yesSensors, 2018
A large number of enzyme inhibitors are used as drugs to treat several diseases such as gout, diabetes, AIDS, depression, Parkinson’s and Alzheimer’s diseases. Electrochemical biosensors based on enzyme inhibition are useful devices for an easy, fast and
Loubna El Harrad   +3 more
doaj   +4 more sources

Enzyme Inhibition

open access: yesCurrent Bioactive Compounds, 2007
One aspect of the importance of enzymes in biology can be appreciated by considering the attention that continues to be focused on the inhibition of enzymatic activity. Historically, inhibitors played important roles in the elucidation of metabolic pathways.
Perry A. Frey, Adrian D. Hegeman
semanticscholar   +4 more sources

Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs

open access: yesMolecules, 2017
The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several pharmacological purposes.
Keith F Tipton, Rona R Ramsay
exaly   +2 more sources

Enzyme inhibition methods based on Au nanomaterials for rapid detection of organophosphorus pesticides in agricultural and environmental samples: A review

open access: yesJournal of Advanced Research, 2022
Background: Organophosphorus pesticides (OPs), as insecticides or acaricides, are widely used in agricultural products to ensure agricultural production.
Rongqi Zhai   +10 more
doaj   +3 more sources

Biosensors Based on Enzyme Inhibition [PDF]

open access: yesAdvances in Biochemical Engineering/Biotechnology, 2013
The present chapter describes the use of biosensors based on enzyme inhibition as analytical tools. The parameters that affect biosensor sensitivity, such as the amount of immobilized enzyme, incubation time, and immobilization type, were critically evaluated, highlighting how the knowledge of enzymatic kinetics can help researchers optimize the ...
ARDUINI, FABIANA, Amine, A.
openaire   +4 more sources

Mixed and non-competitive enzyme inhibition: underlying mechanisms and mechanistic irrelevance of the formal two-site model

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2023
The formal mechanism of linear mixed and non-competitive enzyme inhibition implies the binding of inhibitors to both the active site of the free enzyme in competition with the substrate, and to an allosteric site on the enzyme-substrate complex. However,
A. Pesaresi
semanticscholar   +1 more source

Enzyme inhibition, molecular docking, and density functional theory studies of new thiosemicarbazones incorporating the 4‐hydroxy‐3,5‐dimethoxy benzaldehyde motif

open access: yesArchiv der Pharmazie, 2022
New Schiff base‐bearing thiosemicarbazones (1–13) were obtained from 4‐hydroxy‐3,5‐dimethoxy benzaldehyde and various isocyanates. The structures of the synthesized molecules were elucidated in detail.
Yeliz Demir   +6 more
semanticscholar   +1 more source

Aesculin based glucosamine-6-phosphate synthase inhibitors as novel preservatives for food and pharmaceutical products: in-silico studies, antioxidant, antimicrobial and preservative efficacy evaluation

open access: yesBMC Chemistry, 2021
Background Presently available chemical based synthetic preservative have emerged with various side effects, so the aspiration of natural and side effect free novel preservative has been greatly increased.
Amit Lather   +2 more
doaj   +1 more source

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