Results 21 to 30 of about 963,820 (263)

Natural based piperine derivatives as potent monoamine oxidase inhibitors: an in silico ADMET analysis and molecular docking studies

BMC Chemistry, 2020
Neurodegenerative disorders follow numerous pathological ways concerning overexpression of monoamine oxidase and formation of reactive oxygen species.
Priyanka Dhiman, Neelam Malik, Anurag Khatkar   +2 more
doaj   +1 more source

Hybrid caffeic acid derivatives as monoamine oxidases inhibitors: synthesis, radical scavenging activity, molecular docking studies and in silico ADMET analysis

Chemistry Central Journal, 2018
Background Monoamine oxidase has been implicated in numerous neurological disorders. Although synthetic monoamine oxidase inhibitors (MAOI) have emerged with many side effects, the aspiration of natural based MAOI has greatly increased.
Priyanka Dhiman, Neelam Malik, Anurag Khatkar   +2 more
doaj   +1 more source

Amygdalin based G-6-P synthase inhibitors as novel preservatives for food and pharmaceutical products

Scientific Reports, 2020
G-6-P synthase enzyme has been involved in the synthesis of the microbial cell wall, and its inhibition may lead to the antimicrobial effect. In the present study, we designed a library of amygdalin derivatives, and two most active derivatives selected ...
Amit Lather, Sunil Sharma, Anurag Khatkar   +2 more
doaj   +1 more source

Biosensors Based on Enzyme Inhibition [PDF]

, 2013
The present chapter describes the use of biosensors based on enzyme inhibition as analytical tools. The parameters that affect biosensor sensitivity, such as the amount of immobilized enzyme, incubation time, and immobilization type, were critically evaluated, highlighting how the knowledge of enzymatic kinetics can help researchers optimize the ...
ARDUINI, FABIANA, Amine, A.
openaire   +3 more sources

In-silico design, synthesis, ADMET studies and biological evaluation of novel derivatives of Chlorogenic acid against Urease protein and H. Pylori bacterium

BMC Chemistry, 2019
Background Plants have always played important role in treating human and animal diseases as a therapeutic agent for traditional medicine. Through extensive research throughout the world, potential of natural products have been identified to control the ...
Ritu Kataria, Anurag Khatkar
doaj   +1 more source

Molecular docking, synthesis, kinetics study, structure–activity relationship and ADMET analysis of morin analogous as Helicobacter pylori urease inhibitors

BMC Chemistry, 2019
Background Urease are responsible for several pathogenic states in human as well as in animals and its inhibition is utmost urgent. Clinically used drugs are associated with many side effects; recently several researches have shown that flavonoids have ...
Ritu Kataria, Anurag Khatkar
doaj   +1 more source

Kinetics and computational study of butyrylcholinesterase inhibition by methylrosmarinate: relevance to Alzheimer’s disease treatment

Heliyon, 2022
Butyrylcholinesterase (BChE) performs a significant function in Alzheimer’s disease progression. Experimental studies have shown that the function of BChE in the attenuation of cholinergic neurotransmission is essentially altered in brains of advanced AD
Sani Muhammad Uzairu, Yahaya Tijani, Madu Adamu Gadaka, Babagana Modu, Miriam Watafua, Hadiza Ali Ahmad, Umar Abdullahi Zakariya, Aminu Ibrahim, Aliyu Daja, Hassan Zanna, Abdullahi Balarabe Sallau   +10 more
doaj   +1 more source

In silico design and synthesis of hesperitin derivatives as new xanthine oxidase inhibitors

BMC Chemistry, 2019
Background Hesperitin, a naturally occurring flavonoid was hybridized with phenolic acids to evaluate its potential to inhibit the activity of xanthine oxidase (XO), a key enzyme which catalyses xanthine to uric acid which is found to be associated with ...
Neelam Malik, Priyanka Dhiman, Anurag Khatkar   +2 more
doaj   +1 more source

Point-of-Care Portable 3D-Printed Multispectral Sensor for Real-Time Enzyme Activity Monitoring in Healthcare Applications

Biosensors, 2023
Absorbance spectroscopy finds many biomedical and physical applications ranging from studying the atomic and molecular details of the analyte to determination of unknown biological species and their concentration or activity in the samples.
Antony Jesuraj, Umer Hassan
doaj   +1 more source

In silico design and synthesis of targeted rutin derivatives as xanthine oxidase inhibitors

BMC Chemistry, 2019
Background Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome.
Neelam Malik, Priyanka Dhiman, Anurag Khatkar   +2 more
doaj   +1 more source