Results 21 to 30 of about 665,601 (180)

Syntheses and Biological Activities of 1,4-Iminoalditol Derivatives as ?-L-Fucosidase Inhibitors

CHIMIA, 2011
A review dealing with 1,4-iminoalditol (hydroxylated pyrrolidine) derivatives as inhibitors of ?-L-fucosidases including the different synthetic approaches for their preparation as well as their inhibitory properties is presented.
Elena Moreno-Clavijo, Ana T. Carmona, Antonio J. Moreno-Vargas, Lidia Molina, Inmaculada Robina   +4 more
doaj   +1 more source

Selective Metabolism of Glycosidase Inhibitors by a Specialized Moth Feeding on Flowers

Natural Product Communications, 2008
The British moth Eana incanana (Tortricidae) has been found to selectively metabolize the glycosidase inhibitor 2 R , 3 R , 4 R , 5 R -2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP), whereas it excretes related alkaloids from Hyacinthoides non ...
Alison A. Watson, Ana L. Winters, Sarah A. Corbet, Catherine Tiley, Robert J. Nash   +4 more
doaj   +1 more source

Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine

Molecules, 2020
Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new cyclopentanoid β-galactosidase inhibitors were prepared and their inhibitory and pharmacological chaperoning
Patrick Weber, Martin Thonhofer, Summer Averill, Gideon J. Davies, Andres Gonzalez Santana, Philipp Müller, Seyed A. Nasseri, Wendy A. Offen, Bettina M. Pabst, Eduard Paschke, Michael Schalli, Ana Torvisco, Marion Tschernutter, Christina Tysoe, Werner Windischhofer, Stephen G. Withers, Andreas Wolfsgruber, Tanja M. Wrodnigg, Arnold E. Stütz   +18 more
doaj   +1 more source

Synthesis of α-glycosidase hybrid nano-flowers and their application for enriching and screening α-glycosidase inhibitors

, 2018
To rapidly and accurately screen compounds present in traditional Chinese herbal medicines for α-glycosidase inhibitors, we synthesized a novel nano-affinity material to enable the targeted screening of α-glycosidase inhibitors.
Yuanyuan Zhang, Xiao-Ying Yin, Xi Wan, Jieming Liu, Shuting Gao, Weiting Liu, Han Wang, Kang Qian, Qing-Shan Liu   +8 more
core   +1 more source

Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp²-Iminosugar Glycolipids

Molecules, 2019
The unique stereoelectronic properties of sp2-iminosugars enable their participation in glycosylation reactions, thereby behaving as true carbohydrate chemical mimics.
Elena M. Sánchez-Fernández, M. Isabel García-Moreno, Raquel García-Hernández, José M. Padrón, José M. García Fernández, Francisco Gamarro, Carmen Ortiz Mellet   +6 more
doaj   +1 more source

Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

Molecules, 2018
A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern (d-gluco or l-ido), the architecture of the glycone skeleton, and the nature of the nonglycone substituent has been synthesized and ...
Teresa Mena-Barragán, M. Isabel García-Moreno, Alen Sevšek, Tetsuya Okazaki, Eiji Nanba, Katsumi Higaki, Nathaniel I. Martin, Roland J. Pieters, José M. García Fernández, Carmen Ortiz Mellet   +9 more
doaj   +1 more source

Synthesis, glycosidase inhibitory activity and computational studies of dideoxymethylnojirimycin and its derivatives

Results in Chemistry, 2023
We report here the synthesis and biological evaluation of dideoxynojirimycin and its analogs and their functional effect on glucosidase enzyme inhibition against α-glucosidase(yeast), α-galactosidase and β-galactosidase (kluyveromyces lactis).
Jattuboyina Siva Krishna, Hanumantharayappa Bharathkumar, Saikumar Nalla, Sahadev S Chirke, Shalini Basetty, Vyshnavi Racha, Thenkrishnan Kumaraguru, Ramars Amanchy, Batchu Venkateswara Rao   +8 more
doaj   +1 more source

Protecting-Group-Free Synthesis of 2-Deoxy-Aza-Sugars

Molecules, 2009
The protecting-group-free asymmetric synthesis of 1,2,4-trideoxy-1,4-imino-L-xylitol is readily achieved in five steps from 2-deoxy-D-ribose and with an overall yield of 48%.
Mattie Simon Maria Timmer, Bridget Louise Stocker, Emma Marie Dangerfield, Catherine Heather Plunkett   +3 more
doaj   +1 more source

Glycosylation inhibitors efficiently inhibit P-selectin-mediated cell adhesion to endothelial cells. [PDF]

PLoS ONE, 2014
Adhesion molecules play a critical role in the adhesive interactions of multiple cell types in sickle cell disease (SCD). We previously showed that anti-P-selectin aptamer efficiently inhibits cell adhesion to endothelial cells (ECs) and permits SCD mice
Pushpankur Ghoshal, Mythilypriya Rajendran, Nadine Odo, Tohru Ikuta   +3 more
doaj   +1 more source

Tailored Covalent Organic Frameworks Enable the Encapsulation of Living Cells to Produce Rare Ginsenoside

Advanced Science, EarlyView.
This work reports the in situ fabrication of Escherichia coli@covalent organic frameworks (E. coli@COFs) in phosphate‐buffered saline. The COFs form an exoskeleton on E. coli, protecting intracellular β‐glucosidase (Ssbgl) while enhancing mass transfer.
Fengmei Liu, Shan Zhang, Shanrong Wei, Ziye Xing, Hongming He, Xiao Liang, Quanshun Li   +6 more
wiley   +1 more source