Results 11 to 20 of about 665,601 (180)

Azasugar Glycosidase Inhibitors: Useful Tools for Glycobiologists [PDF]

CHIMIA, 1996
Glycosidase inhibitors are moving increasingly as potential agents for the treatment of diseases by altering glycosylation or catabolism of glycoconjugates.
Sylviane Picasso
doaj   +4 more sources

Functionalization of Glycals Leading to 2-Deoxy-O-glycosides, Aminosugars, Nitrosugars and Glycosidase Inhibitors: Our Experience [PDF]

CHIMIA, 2012
Glycals have been transformed into a variety of functionalized substrates which have been found to be useful in synthesizing some aminosugars, N-glycopeptides, nitrosugars and some iminosugars which are potential glycosidase inhibitors.
Rima Lahiri, Suresh Dharuman, Yashwant D. Vankar   +2 more
doaj   +2 more sources

Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency

, 2022
This review covers the literature in the past 15 years on glycosidase inhibitors lacking a basic nitrogen (for example iminosugars/azasugars) with a focus on natural terpenoids, and mono- and polycyclic aromatic hydrocarbons.
Campkin, David, Houston, Todd A, Wood, Adam, Simone, Michela I, Kiefel, Milton J, Adam Wood, Michela I. Simone, Milton J. Kiefel, David Campkin, Todd A. Houston   +9 more
core   +1 more source

All Eight Stereoisomeric d-Glyconic-δ-lactams:  Synthesis, Conformational Analysis, and Evaluation as Glycosidase Inhibitors

, 2016
An efficient and general synthetic route to all eight stereoisomeric d-glycono-δ-lactams has been developed. The strategy involves, as a key step, a stereodivergent δ-lactam formation with configurational retention or inversion at C-4 of a starting γ ...
Hayamitsu Adachi (1666837), Takahiko Satoh (2995797), Hikaru Nakamura (2312473), Eiki Shitara (3025071), Yoshio Nishimura (1965370), Tomio Takeuchi (2995788), Fukiko Kojima (1965376)   +6 more
core   +3 more sources

Biosynthetic Pathways to Glycosidase Inhibitors [PDF]

, 2014
Glycosidase inhibitors are important compounds that can interfere with several biosynthetic processes including N-linked glycosylation and the biosynthesis of several glycoproteins.
Delso, J. Ignacio, Tejero, Tomás, Gomollón-Bel, Fernando, Merino, Pedro   +3 more
core   +1 more source

Synephrine and phenylephrine act as -amylase, -glycosidase, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase enzymes inhibitors [PDF]

, 2017
In this paper, synephrine and phenylephrine compounds showed excellent inhibitory effects against human carbonic anhydrase (hCA) isoforms I and II, -amylase, -glycosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).
Taslimi, Parham, İlhami Gülçin, Gülçin, İlhami, Akincioglu, Hulya, Parham Taslimi, Akıncıoğlu, Hülya, Hülya Akıncıoglu   +6 more
core   +1 more source

Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins).

PLoS ONE, 2014
Glycosidases are associated with various human diseases. The development of efficient and specific inhibitors may provide powerful tools to modulate their activity.
Agustín Correa, Sabino Pacheco, Ariel E Mechaly, Gonzalo Obal, Ghislaine Béhar, Barbara Mouratou, Pablo Oppezzo, Pedro M Alzari, Frédéric Pecorari   +8 more
doaj   +1 more source

IOOC Route to Substituted Chiral Pyrrolidines. Potential Glycosidase Inhibitors

, 2016
Branched-chain five-membered ring aza-sugar analogues, synthesized from amino acids by an intramolecular oxime−olefin cycloaddition reaction, the IOOC route, were found to be selective glycosidase inhibitors.
Yosi Bechor (3046173), Alfred Hassner (3025266), Abraham Nudelman (331462), Hugo E. Gottlieb (1537900), Eliezer Falb (2529670), Amnon Albeck (2024716)   +5 more
core   +2 more sources

?-Trimethylsilylmethylamine Radical Cation in the Synthesis of Cyclic Amines and Beyond

CHIMIA, 2013
The evolution of chemistry associated with the photoinduced electron transfer (PET)-generated ?-trimethylsilylmethylamine radical cation cyclization to a tethered olefin to synthesize cyclic amine structural frame works is presented in ...
Ganesh Pandey, Debasis Dey, Smita R. Gadre   +2 more
doaj   +1 more source

Stabilizing Functional Nucleic Acids for Real‐Sample Diagnostics

Angewandte Chemie, EarlyView.
Functional nucleic acids enable programmable real‐sample diagnostics, but often lose function in complex biological matrices. This review highlights four stabilization levers—chemical, topological, architectural, and microenvironment/interface engineering—that preserve aptamer and DNAzyme performance in saliva, serum, urine, and stool, reframing ...
Soyeon Lee, Letizia Dondi, Amal Mathai, Connor Nurmi, Yingfu Li   +4 more
wiley   +2 more sources