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Recent research progress of BNCT treatment planning system

Nuclear Engineering and Technology
Boron neutron capture therapy (BNCT) is a type of radiation therapy that can selectively kill tumor cells. It is necessary to design a suitable treatment plan and assess its efficacy based on the actual situation of the patient before BNCT treatment. The
Hongbing Song
exaly   +4 more sources

Accelerator-based BNCT [PDF]

Applied Radiation and Isotopes, 2014
The activity in accelerator development for accelerator-based BNCT (AB-BNCT) both worldwide and in Argentina is described. Projects in Russia, UK, Italy, Japan, Israel, and Argentina to develop AB-BNCT around different types of accelerators are briefly presented.
Mariela Fernanda del Grosso, A A Valda, D M Minsky   +2 more
exaly   +4 more sources

Next-Generation Boron Drugs and Rational Translational Studies Driving the Revival of BNCT

Cells, 2023
BNCT is a high-linear-energy transfer therapy that facilitates tumor-directed radiation delivery while largely sparing adjacent normal tissues through the biological targeting of boron compounds to tumor cells.
Danushka Seneviratne, Omran Saifi, Sunil Krishnan   +2 more
exaly   +3 more sources

Clinical Veterinary Boron Neutron Capture Therapy (BNCT) Studies in Dogs with Head and Neck Cancer: Bridging the Gap between Translational and Clinical Studies

Biology, 2020
Translational Boron Neutron Capture Therapy (BNCT) studies performed by our group and clinical BNCT studies worldwide have shown the therapeutic efficacy of BNCT for head and neck cancer. The present BNCT studies in veterinary patients with head and neck
Amanda E. Schwint, María Silvina Olivera, Marcela A Garabalino   +2 more
exaly   +3 more sources

The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea

Life, 2022
Boron neutron capture therapy (BNCT) is a radiation therapy that selectively kills cancer cells and is being actively researched and developed around the world.
Il Hyeok Seo, Jeongwoo Lee, Dasom Na, Hyunhye Kyung, Jieun Yang, Sangbong Lee, Sang June Jeon, Jae Won Choi, Kyu Young Lee, Jungyu Yi, Jaehwan Han, Mooyoung Yoo, Se Hyun Kim   +12 more
doaj   +1 more source

Therapeutic Efficacy, Radiotoxicity and Abscopal Effect of BNCT at the RA-3 Nuclear Reactor Employing Oligo-Fucoidan and Glutamine as Adjuvants in an Ectopic Colon Cancer Model in Rats

Life, 2023
Boron neutron capture therapy (BNCT) is based on the preferential uptake of 10B compounds by tumors, followed by neutron irradiation. The aim of this study was to assess, in an ectopic colon cancer model, the therapeutic efficacy, radiotoxicity, abscopal
Debora N. Frydryk Benitez, Mónica A. Palmieri, Yanina V. Langle, Andrea Monti Hughes, Emiliano C. C. Pozzi, Silvia I. Thorp, Marcela A. Garabalino, Paula Curotto, Paula S. Ramos, María L. Paparella, Lucas Polti, Ana Eiján, Amanda E. Schwint, Verónica A. Trivillin   +13 more
doaj   +1 more source

Improvement in the neutron beam collimation for application in boron neutron capture therapy of the head and neck region

Scientific Reports, 2022
In June 2020, the Japanese government approved boron neutron capture therapy for the treatment of head and neck cancer. The treatment is usually performed in a single fraction, with the neutron irradiation time being approximately 30–60 min.
Naonori Hu, Hiroki Tanaka, Ryo Kakino, Syuushi Yoshikawa, Mamoru Miyao, Kazuhiko Akita, Teruhito Aihara, Keiji Nihei, Koji Ono   +8 more
doaj   +1 more source

Evaluation of a treatment planning system developed for clinical boron neutron capture therapy and validation against an independent Monte Carlo dose calculation system

Radiation Oncology, 2021
Boron neutron capture therapy (BNCT) for the treatment of unresectable, locally advanced, and recurrent carcinoma of the head and neck cancer has been approved by the Japanese government for reimbursement under the national health insurance as of June ...
Naonori Hu, Hiroki Tanaka, Ryo Kakino, Syuushi Yoshikawa, Mamoru Miyao, Kazuhiko Akita, Kayako Isohashi, Teruhito Aihara, Keiji Nihei, Koji Ono   +9 more
doaj   +1 more source

Exploration of the threshold SUV for diagnosis of malignancy using 18F-FBPA PET/CT

European Journal of Hybrid Imaging, 2022
Background The goal of the study was to evaluate the diagnostic ability of 18F-FBPA PET/CT for malignant tumors. Findings from 18F-FBPA and 18F-FDG PET/CT were compared with pathological diagnoses in patients with malignant tumors or benign lesions ...
Kayako Isohashi, Yasukazu Kanai, Teruhito Aihara, Naonori Hu, Kentaro Fukushima, Ichiro Baba, Fumitoshi Hirokawa, Ryo Kakino, Tsuyoshi Komori, Keiji Nihei, Jun Hatazawa, Koji Ono   +11 more
doaj   +1 more source

NeuTHOR Station—A Novel Integrated Platform for Monitoring BNCT Clinical Treatment, Animal and Cell Irradiation Study at THOR

Life, 2023
(1) Background: A well-established Boron Neutron Capture Therapy (BNCT) facility includes many essential systems, which are the epithermal neutron beam system, on-line monitoring system (OMS), QA/QC (quality assurance or quality control) system, boron ...
Yu-Shiang Huang, Jinn-Jer Peir, Chuan-Jen Wu, Mei-Ya Wang, Yi-Wei Chen, Jia-Cheng Lee, Fong-In Chou   +6 more
doaj   +1 more source