Boron neutron capture therapy combined with immunotherapy: insights from radiotherapy, BNCT-specific evidence, and future directions [PDF]
Frontiers in ImmunologyBoron neutron capture therapy (BNCT), a precision radiotherapy modality, has shown significant promise in targeted cancer treatment. Like conventional radiotherapy, the development of radioresistance hinders the efficacy of BNCT.
Zeyuan Li +10 more
doaj +2 more sources
Applied Radiation and Isotopes, 2014 The activity in accelerator development for accelerator-based BNCT (AB-BNCT) both worldwide and in Argentina is described. Projects in Russia, UK, Italy, Japan, Israel, and Argentina to develop AB-BNCT around different types of accelerators are briefly presented.
Mariela Fernanda Del Grosso +2 more
exaly +4 more sources
Next-Generation Boron Drugs and Rational Translational Studies Driving the Revival of BNCT
Cells, 2023 BNCT is a high-linear-energy transfer therapy that facilitates tumor-directed radiation delivery while largely sparing adjacent normal tissues through the biological targeting of boron compounds to tumor cells.
Danushka Seneviratne +2 more
exaly +3 more sources
Clinical outcomes of boron neutron capture therapy for unresectable oral cancer: a retrospective analysis [PDF]
Frontiers in OncologyBackgroundSurgery is the standard treatment for oral cancer but often causes functional and cosmetic problems, and reoperation is difficult. Radiotherapy (RT) is less effective, with reirradiation limited by normal tissue tolerance and salvage surgery ...
Yuki Yoshino +20 more
doaj +2 more sources
Advances in Clinical Trials of Boron Neutron Capture Therapy [PDF]
ResearchBoron neutron capture therapy (BNCT) is a targeted radiotherapy technique that enables dual targeting at the physico-biological level. Efficient neutron sources and specific boron carriers are essential for successful treatment. By exploiting the 10B(n,α)
Xiaoling Li +5 more
doaj +2 more sources
Boron neutron capture therapy preserves immune cells and induces robust anti-tumour immunity in preclinical mouse model [PDF]
Nature CommunicationsRadiotherapy can both activate and suppress immunity, making it difficult to predict or modulate these opposing effects for better cancer treatment.
Qi Sun +12 more
doaj +2 more sources
Development and evaluation of surface-guided patient position system for boron neutron capture therapy [PDF]
Scientific ReportsBoron Neutron Capture Therapy (BNCT) is an advanced form of radiotherapy that uses the neutron capture reaction of boron-10 to selectively destroy cancer cells.
Jiang Chen +4 more
doaj +2 more sources
Clinical application of boron neutron capture therapy for cancer treatment: A systematic review [PDF]
Precision Radiation OncologyBoron neutron capture therapy (BNCT) combines boron drug delivery and heavy‐ion therapy. The key factors in the application of BNCT are high‐quality neutron beams and boron‐containing compounds.
Ling Zhou +7 more
doaj +2 more sources
Recent research progress of BNCT treatment planning system
Nuclear Engineering and TechnologyBoron neutron capture therapy (BNCT) is a type of radiation therapy that can selectively kill tumor cells. It is necessary to design a suitable treatment plan and assess its efficacy based on the actual situation of the patient before BNCT treatment. The
Hongbing Song
exaly +3 more sources
Manganese-enriched nanoboron agent amplifies BNCT efficacy via pyroptosis-mediated immune activation and STING pathway synergy [PDF]
Journal of NanobiotechnologyBoron Neutron Capture Therapy (BNCT) offers selective tumor cell ablation with minimal damage to normal tissues, but its efficacy is limited by therapy-induced immunosuppression and high intratumoral H2O2 levels, restricting synergy with immunotherapy ...
Zhicheng Zhang +12 more
doaj +2 more sources