Results 11 to 20 of about 8,497 (207)

Clinical application of boron neutron capture therapy for cancer treatment: A systematic review [PDF]

Precision Radiation Oncology
Boron neutron capture therapy (BNCT) combines boron drug delivery and heavy‐ion therapy. The key factors in the application of BNCT are high‐quality neutron beams and boron‐containing compounds.
Ling Zhou, Yuming Chen, Meng Peng, Xiumao Yin, Huanqing Liang, Jieming Mo, Wan Zhang, Zhigang Liu   +7 more
doaj   +2 more sources

Manganese-enriched nanoboron agent amplifies BNCT efficacy via pyroptosis-mediated immune activation and STING pathway synergy​ [PDF]

Journal of Nanobiotechnology
Boron Neutron Capture Therapy (BNCT) offers selective tumor cell ablation with minimal damage to normal tissues, but its efficacy is limited by therapy-induced immunosuppression and high intratumoral H2O2 levels, restricting synergy with immunotherapy ...
Zhicheng Zhang, Xiaoyan Sun, Yaxin Qin, Yufan Yang, Qi Dai, Xiaoyan Bao, Minoru Suzuki, Sheng Wang, Zai Yang, Zhifeng Li, Min Han, Donghang Xu, Qichun Wei   +12 more
doaj   +2 more sources

The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea

Life, 2022
Boron neutron capture therapy (BNCT) is a radiation therapy that selectively kills cancer cells and is being actively researched and developed around the world.
Il Hyeok Seo, Jeongwoo Lee, Dasom Na, Hyunhye Kyung, Jieun Yang, Sangbong Lee, Sang June Jeon, Jae Won Choi, Kyu Young Lee, Jungyu Yi, Jaehwan Han, Mooyoung Yoo, Se Hyun Kim   +12 more
doaj   +1 more source

Therapeutic Efficacy, Radiotoxicity and Abscopal Effect of BNCT at the RA-3 Nuclear Reactor Employing Oligo-Fucoidan and Glutamine as Adjuvants in an Ectopic Colon Cancer Model in Rats

Life, 2023
Boron neutron capture therapy (BNCT) is based on the preferential uptake of 10B compounds by tumors, followed by neutron irradiation. The aim of this study was to assess, in an ectopic colon cancer model, the therapeutic efficacy, radiotoxicity, abscopal
Debora N. Frydryk Benitez, Mónica A. Palmieri, Yanina V. Langle, Andrea Monti Hughes, Emiliano C. C. Pozzi, Silvia I. Thorp, Marcela A. Garabalino, Paula Curotto, Paula S. Ramos, María L. Paparella, Lucas Polti, Ana Eiján, Amanda E. Schwint, Verónica A. Trivillin   +13 more
doaj   +1 more source

Development and dosimetric evaluation of a freely deformable ⁶Li-based neutron shield for boron neutron capture therapy. [PDF]

Med Phys
Abstract Background Boron neutron capture therapy (BNCT) enables selective tumor irradiation by exploiting the high‐linear energy transfer particles generated from neutron interactions with 10B atoms. BNCT has been approved as an insurance‐covered medical treatment for recurrent head and neck cancer in Japan.
Hu N, Kakino R, Sasaki A, Nojiri M, Akita K, Yoshikawa S, Kohigashi Y, Yoshino Y, Takeno S, Aihara T, Takata T, Tanaka H, Nihei K, Ono K.   +13 more
europepmc   +2 more sources

Evaluation of a treatment planning system developed for clinical boron neutron capture therapy and validation against an independent Monte Carlo dose calculation system

Radiation Oncology, 2021
Boron neutron capture therapy (BNCT) for the treatment of unresectable, locally advanced, and recurrent carcinoma of the head and neck cancer has been approved by the Japanese government for reimbursement under the national health insurance as of June ...
Naonori Hu, Hiroki Tanaka, Ryo Kakino, Syuushi Yoshikawa, Mamoru Miyao, Kazuhiko Akita, Kayako Isohashi, Teruhito Aihara, Keiji Nihei, Koji Ono   +9 more
doaj   +1 more source

Improvement in the neutron beam collimation for application in boron neutron capture therapy of the head and neck region

Scientific Reports, 2022
In June 2020, the Japanese government approved boron neutron capture therapy for the treatment of head and neck cancer. The treatment is usually performed in a single fraction, with the neutron irradiation time being approximately 30–60 min.
Naonori Hu, Hiroki Tanaka, Ryo Kakino, Syuushi Yoshikawa, Mamoru Miyao, Kazuhiko Akita, Teruhito Aihara, Keiji Nihei, Koji Ono   +8 more
doaj   +1 more source

Exploration of the threshold SUV for diagnosis of malignancy using 18F-FBPA PET/CT

European Journal of Hybrid Imaging, 2022
Background The goal of the study was to evaluate the diagnostic ability of 18F-FBPA PET/CT for malignant tumors. Findings from 18F-FBPA and 18F-FDG PET/CT were compared with pathological diagnoses in patients with malignant tumors or benign lesions ...
Kayako Isohashi, Yasukazu Kanai, Teruhito Aihara, Naonori Hu, Kentaro Fukushima, Ichiro Baba, Fumitoshi Hirokawa, Ryo Kakino, Tsuyoshi Komori, Keiji Nihei, Jun Hatazawa, Koji Ono   +11 more
doaj   +1 more source

Dose-Dependent Suppression of Human Glioblastoma Xenograft Growth by Accelerator-Based Boron Neutron Capture Therapy with Simultaneous Use of Two Boron-Containing Compounds

Biology, 2021
(1) Background: Developments in accelerator-based neutron sources moved boron neutron capture therapy (BNCT) to the next phase, where new neutron radiation parameters had to be studied for the treatment of cancers, including brain tumors.
Vladimir Kanygin, Ivan Razumov, Alexander Zaboronok, Evgenii Zavjalov, Aleksandr Kichigin, Olga Solovieva, Alphiya Tsygankova, Tatiana Guselnikova, Dmitrii Kasatov, Tatiana Sycheva, Bryan J. Mathis, Sergey Taskaev   +11 more
doaj   +1 more source

NeuTHOR Station—A Novel Integrated Platform for Monitoring BNCT Clinical Treatment, Animal and Cell Irradiation Study at THOR

Life, 2023
(1) Background: A well-established Boron Neutron Capture Therapy (BNCT) facility includes many essential systems, which are the epithermal neutron beam system, on-line monitoring system (OMS), QA/QC (quality assurance or quality control) system, boron ...
Yu-Shiang Huang, Jinn-Jer Peir, Chuan-Jen Wu, Mei-Ya Wang, Yi-Wei Chen, Jia-Cheng Lee, Fong-In Chou   +6 more
doaj   +1 more source