Results 11 to 20 of about 6,494 (198)

Microdosimetry in BNCT [PDF]

Health and Technology
Precision Radiation Oncology, EarlyView.
Valeria Conte, Anna Bianchi, Anna Selva
europepmc   +4 more sources

Multi-fidelity Monte Carlo fusion for BNCT dose calculation using a dual-branch network. [PDF]

Med Phys
Abstract Background Boron neutron capture therapy (BNCT) is a binary radiotherapy that selectively kills tumor cells. Its clinical implementation relies on Monte Carlo (MC)‐based treatment planning systems, which are time‐consuming and limit clinical workflow efficiency.
Li L, Hong X, Wang Y, Huang G, Wu Z, Xiao Y, Tanaka H, Watabe H.   +7 more
europepmc   +2 more sources

A coarse-to-fine framework combining deep learning and Monte Carlo for BNCT patient position optimization toward inverse planning. [PDF]

Med Phys
Abstract Background Boron Neutron Capture Therapy (BNCT) utilizes high linear energy transfer (LET) charged particles from the 10B(n,α)7Li reaction to selectively destroy tumor cells. Unlike conventional radiation therapy, BNCT facilities rely on fixed beam ports, making patient positioning critical in treatment planning.
Na Y, Lee CM, Kim K, Cho H, Lee J, Ye SJ.   +5 more
europepmc   +2 more sources

Safety, efficacy, pharmacokinetics, and mechanisms of novel ¹⁰B-boronophenylalanine combined with a radio-frequency quadrupole accelerator in boron neutron capture therapy: A preclinical study in head and neck squamous cell carcinoma. [PDF]

Precis Radiat Oncol
This study demonstrates that the novel 10B‐BPA‐based BNCT system, combined with an RFQ accelerator, effectively targets head and neck squamous cell carcinoma. It induces tumor regression safely and efficiently by triggering DNA damage and activating the ROS/HIF‐1α/NF‐κB pathway, leading to caspase‐3‐mediated apoptosis.
Zhang Z, Li J, Fan M, Ouyang H, Chu Q, Yan H, Zheng Y, Huang L, Bao G, Ma Z, Huang S, Li L, Xu X, Liu Z.   +13 more
europepmc   +2 more sources

Advances in boron neutron capture therapy (BNCT) at kyoto university - From reactor-based BNCT to accelerator-based BNCT [PDF]

Journal of the Korean Physical Society, 2015
At the Kyoto University Research Reactor Institute (KURRI), a clinical study of boron neutron capture therapy (BNCT) using a neutron irradiation facility installed at the research nuclear reactor has been regularly performed since February 1990. As of November 2014, 510 clinical irradiations were carried out using the reactor-based system.
Sakurai, Yoshinori, Tanaka, Hiroki, Takata, Takushi, Fujimoto, Nozomi, Suzuki, Minoru, Masunaga, Shinichiro, Kinashi, Yuko, Kondo, Natsuko, Narabayashi, Masaru, Nakagawa, Yosuke, Watanabe, Tsubasa, Ono, Koji, Maruhashi, Akira   +12 more
openaire   +3 more sources

Quantification of ¹⁰B and ¹¹B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT). [PDF]

Med Res Rev
ABSTRACT Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low‐energy neutrons to induce high linear energy transfer particles with short path lengths, resulting in localized tumor cell destruction while sparing surrounding healthy ...
Selg C, Sauerwein WAG, Hey-Hawkins E.
europepmc   +2 more sources

Transporter-Associated Therapeutic Efficacy of an SMVT-Targeted Boron Carrier in Boron Neutron Capture Therapy. [PDF]

Cancer Sci
The transporter‐associated BNCT strategy using BBCIP with or without BPA according to tumor transporter characteristics. BPA showed greater efficacy in LAT1‐dominant F98 glioma, whereas BBCIP was more effective in SMVT‐high CRL1666 tumors, suggesting the potential utility of transporter‐based boron carrier selection in BNCT.
Eza K, Tsujino K, Shidoh-Kazuki R, Fujikawa Y, Kashiwagi H, Futamura G, Hiramatsu R, Takami T, Wanibuchi M, Hu N, Tanaka H, Suzuki M, Nishimura K, Tanaka S, Nakamura H, Kawabata S.   +15 more
europepmc   +2 more sources

Boron neutron capture therapy combined with immunotherapy: insights from radiotherapy, BNCT-specific evidence, and future directions [PDF]

Frontiers in Immunology
Boron neutron capture therapy (BNCT), a precision radiotherapy modality, has shown significant promise in targeted cancer treatment. Like conventional radiotherapy, the development of radioresistance hinders the efficacy of BNCT.
Zeyuan Li, Haolin Cai, Xiukui Cheng, Linping Qi, Xingda Wang, Ting Yang, Can Li, Yumin Li, Yumin Li, Cong Chen, Cong Chen   +10 more
doaj   +2 more sources

Biomimetic Macrophage Cell Membrane-Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy. [PDF]

Adv Sci (Weinh)
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Chen J, You H, Huang H, Chai H, Zhu R, Guan Y, Tang Q, Li T, Jiang S, Xu H, Wang P, Wang Y, Sun M, Liu B, Li Z, Zeng Y, Ping W, Teng Y, Yan S, Li Q, Gu L, Sun T, Shi Z.   +22 more
europepmc   +2 more sources

Combined BNCT and PET for theranostics

Bio-Algorithms and Med-Systems, 2021
Abstract This short review summarizes the issue of boron distribution monitoring in boron neutron capture therapy (BNCT), which remains a serious drawback of this powerful oncological treatment. Here we present the monitoring methods that are presently used with particular emphasis on the positron emission tomography (PET) which has the ...
Silarski, Michał, Dziedzic-Kocurek, Katarzyna, Szczepanek, Monika   +2 more
openaire   +4 more sources