Advances in boron neutron capture therapy (BNCT) at kyoto university - From reactor-based BNCT to accelerator-based BNCT [PDF]
Journal of the Korean Physical Society, 2015 At the Kyoto University Research Reactor Institute (KURRI), a clinical study of boron neutron capture therapy (BNCT) using a neutron irradiation facility installed at the research nuclear reactor has been regularly performed since February 1990. As of November 2014, 510 clinical irradiations were carried out using the reactor-based system.
Sakurai, Yoshinori +12 more
openaire +1 more source
The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications
Angewandte Chemie, EarlyView.This work describes the synthesis of bench‐stable dicationic carboranes. Their enhanced electrophilicity is documented by opening the clusters with weak nucleophiles or dihydrogen. The surprising stability of positively charged carboranes in water enabled a study of their in vitro antiproliferative activity, which surpassed the effects of doxorubicin ...
Vlastimil Němec +10 more
wiley +2 more sources
Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma [PDF]
, 2009 Background Boron neutron capture therapy (BNCT) is a selective radiotherapy, being effective for the treatment of even advanced malignancies in head and neck regions as well as brain tumors and skin melanomas.
Yusei Fujita +8 more
core +1 more source
Angewandte Chemie, EarlyView.A light mediated direct regioselective B─H functionalization, via hydrogen atom transfer (HAT), is described. Unexplored xanthyl‐closo‐carboranes as novel bench‐stable and versatile platforms to access sulfur‐containing boron clusters are reported for the first time.
Marco Rusconi +9 more
wiley +2 more sources
Radiobiological response of U251MG, CHO-K1 and V79 cell lines to accelerator-based boron neutron capture therapy [PDF]
, 2017 In the current article, we provide in vitro efficacy evaluation of a unique accelerator-based neutron source, constructed at the Budker Institute of Nuclear Physics (Novosibirsk, Russian Federation), for boron neutron capture therapy (BNCT), which is ...
Isobe Tomonori +15 more
core +2 more sources
PLoS ONE, 2019 Nine patients with recurrent head and neck (H&N) cancer received boron neutron capture therapy (BNCT) in one fraction at the Tsing-Hua Open pool reactor (THOR) utilizing the THORplan treatment planning system (TPS).
Jia-Cheng Lee +5 more
doaj +1 more source
Current development status of accelerator-based neutron source for boron neutron capture therapy
EPJ Techniques and Instrumentation, 2023 Recently, progress in technology for accelerator-based neutron sources has increased attention regarding boron neutron capture therapy (BNCT). BNCT is a type of radiotherapy that combines neutrons and boron drugs and is expected to be used in the ...
Hiroaki Kumada +2 more
doaj +1 more source
Editorial: 3<sup>rd</sup> international workshop on microdosimetry for particle therapy: Bridging physics and biology. [PDF]
Precis Radiat OncolPrecision Radiation Oncology, Volume 10, Issue 1, Page 4-6, March 2026.
Barna S +9 more
europepmc +2 more sources
The Anti-Proliferative Effect of Boron Neutron Capture Therapy in a Prostate Cancer Xenograft Model. [PDF]
PLoS ONE, 2015 Boron neutron capture therapy (BNCT) is a selective radiation treatment for tumors that preferentially accumulate drugs carrying the stable boron isotope, 10B. BNCT has been evaluated clinically as an alternative to conventional radiation therapy for the
Kiyoshi Takahara +14 more
doaj +1 more source
Advances of LINAC-based boron neutron capture therapy in Korea
AAPPS Bulletin, 2022 Boron neutron capture therapy (BNCT) has been attracting interest as a new radiation modality for cancer therapy because it can selectively destroy cancer cells while maintaining the healthy state of surrounding normal cells.
Young-soon Bae +47 more
doaj +1 more source