Results 41 to 50 of about 6,494 (198)

An Introduction to Boron Neutron Therapy (BNCT): Current Status and Future Outlook

Iranian South Medical Journal, 2021
Boron neutron capture therapy (BNCT) is based on the nuclear reaction, such that B-10 irradiated with low-energy thermal neutrons produces alpha particles with high linear energy transfer and lithium-7. Clinically, BNCT is used primarily for treatment of
Malehe Omrani, Esmaeil Jafari, Zenab Alipour, Hajar Zarei   +3 more
doaj  

Salvage Boron Neutron Capture Therapy for Malignant Brain Tumor Patients in Compliance with Emergency and Compassionate Use: Evaluation of 34 Cases in Taiwan

Biology, 2021
Although boron neutron capture therapy (BNCT) is a promising treatment option for malignant brain tumors, the optimal BNCT parameters for patients with immediately life-threatening, end-stage brain tumors remain unclear.
Yi-Wei Chen, Yi-Yen Lee, Chun-Fu Lin, Po-Shen Pan, Jen-Kun Chen, Chun-Wei Wang, Shih-Ming Hsu, Yu-Cheng Kuo, Tien-Li Lan, Sanford P. C. Hsu, Muh-Lii Liang, Robert Hsin-Hung Chen, Feng-Chi Chang, Chih-Chun Wu, Shih-Chieh Lin, Hsiang-Kuang Liang, Jia-Cheng Lee, Shih-Kuan Chen, Hong-Ming Liu, Jinn-Jer Peir, Ko-Han Lin, Wen-Sheng Huang, Kuan-Hsuan Chen, Yu-Mei Kang, Shueh-Chun Liou, Chun-Chieh Wang, Ping-Ching Pai, Chih-Wei Li, Daniel Quah Song Chiek, Tai-Tong Wong, Shih-Hwa Chiou, Yee Chao, Hiroki Tanaka, Fong-In Chou, Koji Ono   +34 more
doaj   +1 more source

Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma

Advanced Science, EarlyView.
Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul, Alexandra Moreno Mitchell, Dean O'Neil, Yutong Luo, Khuloud T. Al‐Jamal   +4 more
wiley   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

Extracellular Release of HMGB1 as an Early Potential Biomarker for the Therapeutic Response in a Xenograft Model of Boron Neutron Capture Therapy

Biology, 2022
Boron neutron capture therapy (BNCT) is a non-invasive therapeutic technique for treating malignant tumors, however, methods to evaluate its therapeutic efficacy and adverse reactions are lacking.
Shoji Imamichi, Lichao Chen, Tasuku Ito, Ying Tong, Takae Onodera, Yuka Sasaki, Satoshi Nakamura, PierLuigi Mauri, Yu Sanada, Hiroshi Igaki, Yasufumi Murakami, Minoru Suzuki, Jun Itami, Shinichiro Masunaga, Mitsuko Masutani   +14 more
doaj   +1 more source

Possibilities of boron neutron capture therapy in the treatment of malignant brain tumors

Вестник рентгенологии и радиологии, 2016
Boron neutron capture therapy (BNCT) that is of the highest attractiveness due to its selective action directly on malignant tumor cells is a promising approach to treating cancers.
V. V. Kanygin, A. I. Kichigin, N. V. Gubanova, S. Yu Taskaev   +3 more
doaj   +1 more source

Chitosan-lactobionic acid-thioctic acid-modified hollow mesoporous silica composite loaded with carborane for boron neutron capture therapy of hepatocellular carcinoma

Materials & Design, 2022
Nanocarriers have been recognized as an effective strategy for developing novel boron-containing delivery agents for boron neutron capture therapy (BNCT) of refractory tumors.
Taofeng Zhang, Dan Xu, Yangman Yi, Yu Wang, Zhencun Cui, Xiujuan Chen, Qianlong Ma, Fuxiang Song, Bowu Zhu, Zhongfang Zhao, Judong Cao, Dian He, Ximeng Chen, Bin Liu   +13 more
doaj   +1 more source

Radiation Shielding Performance of B4C‐Reinforced Ultra‐High Molecular Weight Polyethylene Composites Against Low‐Energy X‐Rays: Experimental and Computational Analysis

Polymer Composites, EarlyView.
Radiation shielding behavior of B4C‐reinforced UHMWPE composites. ABSTRACT The present study investigates the radiation shielding performance of ultra‐high molecular weight polyethylene (UHMWPE) composites reinforced with varying boron carbide (B4C) contents against low‐energy X‐rays through combined experimental and computational approaches.
Elif Altındaş, Yalçın Kalkan, Gozde Celebi Efe, Aysun Ayday, Tuba Yener   +4 more
wiley   +1 more source

Mechanotransduction-related ferroptosis: Enhancing boron neutron capture therapy efficacy in glioblastoma using a spheroid model

Molecular Therapy: Oncology
Boron neutron capture therapy (BNCT) shows potential for the treatment of glioblastoma, the most aggressive form of primary brain tumor. Recently, ferroptosis, a cell death triggered by phospholipid peroxidation, has been identified as an important ...
Lin-Sheng Yu, Jia-Jun Liu, Ming-Hung Yang, Yu-chun Lin, Chi-Shuo Chen   +4 more
doaj   +1 more source

Experimental proof-of-concept and first field tests of the dual gamma-neutron imager GN-Vision [PDF]

EPJ Web of Conferences
GN-Vision is a compact dual-modality imaging system designed to simultaneously localize the spatial origin of γ-ray and slow neutron sources, with promising applications in hadron therapy, particularly Boron Neutron Capture Therapy (BNCT).
Sanchis-Moltó A., Lerendegui-Marco J., Cisterna G., Álvarez-Rodríguez P., Balibrea-Correa J., Babiano-Suárez V., Daugas J-M., de la Fuente G., Gameiro B., Ladarescu I., Méndez-Malagón C., Michelagnoli C., Porras I., Navarro-Mocholi A., Porras-Quesada M., Ruiz-Ruiz C., Torres-Sánchez P., Valladarés S., Domingo-Pardo C.   +18 more
doaj   +1 more source