Results 1 to 10 of about 2,734 (132)

Radiation-Triggered Chemokine-Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy. [PDF]

Adv Sci (Weinh)
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Liu Y, Qian Y, Huang S, Li B, Yu Y, Cheng X, Chen C, Wang J, Yang M, Liang L, Meng X, Liu Z.   +11 more
europepmc   +2 more sources

Boron‐embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma [PDF]

Smart Mol
A brain‐targeting multifunctional nanoplatform (DM&Ce6@COF‐Ang) was engineered by employing boron‐enriched APTES‐COF‐1 as both the therapeutic boron agent and the nanocarrier co‐delivery of DMXAA and Ce6. This nanoplatform achieved synergistic tumor‐specific boron delivery, real‐time pharmacokinetic monitoring, and immunomodulation.
Liu Y, Wang X, Li B, Shao K, Su J, Wang Y, Cheng L, Wu Z, Li J, Zhang G, Wang X, Zhang Y, Liu Y, Li G.   +13 more
europepmc   +2 more sources

Potential targets for boron transport in boron neutron capture therapy [PDF]

Frontiers in Oncology
Boron Neutron Capture Therapy (BNCT) is a binary cancer therapy that involves boron (10B) drug administration and epithermal/thermal neutron irradiation. The nuclear fission reaction between low-energy thermal neutrons and 10B atoms accumulated in cancer
Yucai Wei, Yucai Wei, Yucai Wei, Weijing Zhu, Weijing Zhu, Qian Chen, Huda Alnufaei, Yumin Li, Yumin Li, Kate Ricketts   +9 more
doaj   +2 more sources

Biomimetic Macrophage Cell Membrane-Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy. [PDF]

Adv Sci (Weinh)
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Chen J, You H, Huang H, Chai H, Zhu R, Guan Y, Tang Q, Li T, Jiang S, Xu H, Wang P, Wang Y, Sun M, Liu B, Li Z, Zeng Y, Ping W, Teng Y, Yan S, Li Q, Gu L, Sun T, Shi Z.   +22 more
europepmc   +2 more sources

Systemic Immunity Triggered by Boron Neutron Capture Therapy via Manganese-Borate Complex [PDF]

Materials Today Bio
Conventional radiotherapy compromises antitumor immunity through collateral damage to immune cells. While boron neutron capture therapy (BNCT) enables tumor-selective 10B (n, α) 7Li reactions, clinical agents like boronophenylalanine (BPA) suffer from ...
Chang Chen, Chao Wang, Lin Zhang, Yue Yu, Xu Li, Wenhao Pan, Yuanyu Liu, Jiheng Wang, Maosong Yang, Bing Hong, Xingguang Hu, Jichao Wang, Yuzhong Qian, Xiancai Meng, Yinghuai Zhu, Zhigang Liu, Shaobo Huang, Lizheng Liang, Jinhui Wu, Yang Liu   +19 more
doaj   +2 more sources

Clinical application of boron neutron capture therapy for cancer treatment: A systematic review [PDF]

Precision Radiation Oncology
Boron neutron capture therapy (BNCT) combines boron drug delivery and heavy‐ion therapy. The key factors in the application of BNCT are high‐quality neutron beams and boron‐containing compounds.
Ling Zhou, Yuming Chen, Meng Peng, Xiumao Yin, Huanqing Liang, Jieming Mo, Wan Zhang, Zhigang Liu   +7 more
doaj   +2 more sources

Quantification of ¹⁰B and ¹¹B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT). [PDF]

Med Res Rev
ABSTRACT Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low‐energy neutrons to induce high linear energy transfer particles with short path lengths, resulting in localized tumor cell destruction while sparing surrounding healthy ...
Selg C, Sauerwein WAG, Hey-Hawkins E.
europepmc   +2 more sources

Investigation of photon doses reaching healthy tissues in the use of different neutron energies in boron neutron capture therapy [PDF]

Nuclear Technology and Radiation Protection, 2022
Boron neutron capture therapy is a unique treatment method that aims to kill the tumor cells with the help of heavy particles. Particles resulting from the interaction of the tumor region containing 10B atoms with thermal or epithermal neutrons ...
Tugrul Taylan
doaj   +1 more source

Construction of targeted 10B delivery agents and their uptake in gastric and pancreatic cancer cells

Frontiers in Oncology, 2023
Boron Neutron Capture Therapy (BNCT) is a new binary radiation therapy for tumor tissue, which kills tumor cells with neutron capture reaction. Boron neutron capture therapy has become a technical means for glioma, melanoma, and other diseases has been ...
Song Wang, Song Wang, Zhengchao Zhang, Zhengchao Zhang, Lele Miao, Lele Miao, Jiaxing Zhang, Jiaxing Zhang, Futian Tang, Futian Tang, Muzhou Teng, Muzhou Teng, Yumin Li, Yumin Li   +13 more
doaj   +1 more source

Neutron flux evaluation model provided in the accelerator-based boron neutron capture therapy system employing a solid-state lithium target

Scientific Reports, 2021
An accelerator-based boron neutron capture therapy (BNCT) system employing a solid-state Li target can achieve sufficient neutron flux for treatment although the neutron flux is reduced over the lifetime of its target.
Satoshi Nakamura, Hiroshi Igaki, Masashi Ito, Shoji Imamichi, Tairo Kashihara, Hiroyuki Okamoto, Shie Nishioka, Kotaro Iijima, Takahito Chiba, Hiroki Nakayama, Mihiro Takemori, Yoshihisa Abe, Tomoya Kaneda, Kana Takahashi, Koji Inaba, Kae Okuma, Naoya Murakami, Yuko Nakayama, Mitsuko Masutani, Teiji Nishio, Jun Itami   +20 more
doaj   +1 more source