Results 21 to 30 of about 588 (131)

Boron Neutron Capture Therapy: From Nuclear Physics to Biomedicine

Biology, 2021
Boron Neutron Capture Therapy (BNCT) is a binary radiation treatment exploiting a nuclear reaction occurring in tumor cells [...]
Silva Bortolussi, Yuan-Hao Liu, Ignacio Porras   +2 more
doaj   +1 more source

Monte Carlo assessment of boron neutron capture therapy for the treatment of breast cancer [PDF]

Nuclear Technology and Radiation Protection, 2005
For a large number of women who are diagnosed with breast cancer every year the avail able treatment options are effective, though physically and mentally taxing.
Mundy Daniel W., Jevremović Tatjana
doaj   +1 more source

Amino Acid-Based Boron Carriers in Boron Neutron Capture Therapy (BNCT)

Pharmaceutics, 2023
Interest in the design of boronated amino acids has emerged, partly due to the utilization of boronophenylalanine (BPA), one of the two agents employed in clinical Boron Neutron Capture Therapy (BNCT).
Juulia Järvinen, Herkko Pulkkinen, Jarkko Rautio, Juri M. Timonen   +3 more
doaj   +1 more source

Dosimetry for boron neutron capture therapy developed and verified at the accelerator based neutron source VITA

Frontiers in Nuclear Engineering, 2023
The method of boron neutron capture therapy for malignant tumors, proposed in 1936, is beginning to enter clinical practice. The development of dosimetry tools for characterization of therapeutic mixed neutron-photon beam and assessing the patient’s ...
Marina Bikchurina, Timofey Bykov, Ibrahim Ibrahim, Ibrahim Ibrahim, Ibrahim Ibrahim, Anna Kasatova, Dmitrii Kasatov, Iaroslav Kolesnikov, Victoria Konovalova, Victoria Konovalova, Timur Kormushakov, Timur Kormushakov, Alexey Koshkarev, Alexey Koshkarev, Anton Kuznetsov, Anton Kuznetsov, Vyacheslav Porosev, Sergey Savinov, Ivan Shchudlo, Nataliia Singatulina, Nataliia Singatulina, Evgeniia Sokolova, Tatiana Sycheva, Iuliia Taskaeva, Gleb Verkhovod, Sergey Taskaev, Sergey Taskaev   +26 more
doaj   +1 more source

Feasibility of Prompt Gamma-Ray Imaging in BNCT: SPECT-Based MCNP Simulations of Boron and Hydrogen Capture Events [PDF]

Journal of Radiation Protection and Research
Background Boron neutron capture therapy (BNCT) is a targeted radiotherapy that selectively destroys cancer cells by delivering compounds enriched in boron-10 (10B) that preferentially accumulate in tumors.
Milad Mohammedali, Wonho Lee
doaj   +1 more source

Boron delivery for boron neutron capture therapy targeting a cancer-upregulated oligopeptide transporter

Journal of Pharmacological Sciences, 2019
Boron neutron capture therapy (BNCT) is a radiotherapy utilizing the neutron capture and nuclear fission reaction of 10B taken up into tumor cells. The most commonly used boron agent in BNCT, p-borono-l-phenylalanine (BPA), is accumulated in tumors by ...
Junji Miyabe, Ryuichi Ohgaki, Keijiro Saito, Ling Wei, Lili Quan, Chunhuan Jin, Xingming Liu, Suguru Okuda, Shushi Nagamori, Hiroshi Ohki, Kazuo Yoshino, Hidenori Inohara, Yoshikatsu Kanai   +12 more
doaj   +1 more source

PK Modeling of L-4-Boronophenylalanine and Development of Bayesian Predictive Platform for L-4-Boronophenylalanine PKs for Boron Neutron Capture Therapy

Pharmaceuticals
L-4-[(10B)]Boronophenylalanine (BPA) is an amino acid analogue with a boron-10 moiety. It is most widely used as a boron carrier in boron neutron capture therapy.
Woohyoung Kim, Ji Yeong Won, Jungyu Yi, Seung Chan Choi, Sang Min Lee, Kyungran Mun, Hyeong-Seok Lim   +6 more
doaj   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Localized nuclear reaction breaks boron drug capsules loaded with immune adjuvants for cancer immunotherapy

Nature Communications, 2023
Boron neutron capture therapy (BNCT) was clinically approved in 2020 and exhibits remarkable tumour rejection in preclinical and clinical studies. It is binary radiotherapy that may selectively deposit two deadly high-energy particles (4He and 7Li ...
Yaxin Shi, Zhibin Guo, Qiang Fu, Xinyuan Shen, Zhongming Zhang, Wenjia Sun, Jinqiang Wang, Junliang Sun, Zizhu Zhang, Tong Liu, Zhen Gu, Zhibo Liu   +11 more
doaj   +1 more source

Charge‐Transfer‐Mediated Boron Magneto‐Ionics: Towards Voltage‐Driven Multi‐Ion Transport

Advanced Science, EarlyView.
This study demonstrates voltage‐driven multi‐ion transport in FeBO systems, revealing simultaneous motion of B, Fe, and O ions enabled by charge‐transfer effects. By tuning oxidation states through oxygen incorporation, we achieve a transition from electrostatic‐like to electrochemical magneto‐ionic behavior. The findings establish boron magneto‐ionics,
Zheng Ma, Karim‐Alexandros Kantre, Huan Tan, Aitor Arredondo‐López, Maciej O. Liedke, Javier Herrero‐Martín, Eric Hirschmann, Andreas Wagner, Daniel Mora‐Blanco, Alberto Quintana, Salvador Pané, Eva Pellicer, Josep Nogués, Johan Meersschaut, Jordi Sort, Enric Menéndez   +15 more
wiley   +1 more source