Results 41 to 50 of about 3,756,603 (159)

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Multi-Functional Boron-Delivery Agents for Boron Neutron Capture Therapy of Cancers [PDF]

, 2023
Boron neutron capture therapy (BNCT) is a binary cancer treatment that involves the irradiation of 10B-containing tumors with low-energy neutrons (thermal or epithermal).
Vicente, Maria da Graça H., Oloo, Sebastian O., Kevin M. Smith, Sebastian O. Oloo, Maria da Graça H. Vicente, Smith, Kevin M.   +5 more
core   +1 more source

A method for delivering the required neutron fluence in an accelerator-based boron neutron capture therapy system employing a lithium target

Scientific Reports
Accelerator-based boron neutron capture therapy (BNCT) systems employing a solid-state lithium target indicated the reduction of neutron flux over the lifetime of a target, and its reduction could represent the neutron flux model.
Satoshi Nakamura, Mihiro Takemori, Tetsu Nakaichi, Yasunori Shuto, Tairo Kashihara, Kotaro Iijima, Takahito Chiba, Hiroki Nakayama, Yuka Urago, Shuka Nishina, Yuta Kobayashi, Hironori Kishida, Shoji Imamichi, Kana Takahashi, Mitsuko Masutani, Hiroyuki Okamoto, Teiji Nishio, Jun Itami, Hiroshi Igaki   +18 more
doaj   +1 more source

Localized nuclear reaction breaks boron drug capsules loaded with immune adjuvants for cancer immunotherapy

Nature Communications, 2023
Boron neutron capture therapy (BNCT) was clinically approved in 2020 and exhibits remarkable tumour rejection in preclinical and clinical studies. It is binary radiotherapy that may selectively deposit two deadly high-energy particles (4He and 7Li ...
Yaxin Shi, Zhibin Guo, Qiang Fu, Xinyuan Shen, Zhongming Zhang, Wenjia Sun, Jinqiang Wang, Junliang Sun, Zizhu Zhang, Tong Liu, Zhen Gu, Zhibo Liu   +11 more
doaj   +1 more source

Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma

Advanced Science, EarlyView.
Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul, Alexandra Moreno Mitchell, Dean O'Neil, Yutong Luo, Khuloud T. Al‐Jamal   +4 more
wiley   +1 more source

Correcting for the heterogeneous boron distribution in a tumor for BNCT dose calculation

Scientific Reports, 2023
Most treatment planning systems of boron neutron capture therapy perform dose calculations based on the assumption of a homogeneous boron distribution in tumors, which leads to dose distortion due to the difference between the tumor-to-normal tissue ...
Yi-Chiao Teng, Jiang Chen, Wan-Bing Zhong, Yuan-Hao Liu   +3 more
doaj   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

BeNEdiCTE (Boron Neutron Capture): A Versatile Gamma-Ray Detection Module for Boron Neutron Capture Therapy

, 2022
We present a gamma-ray detection module for quantifying the boron neutron capture events that occur in the boron neutron capture therapy (BNCT) and neutron capture enhanced particle therapy (NCEPT).
Anita Caracciolo (20251914), Marco Carminati (1654012), Mitra Safavi-Naeini (19014764), Davide Di Vita (20251920), Ilenia D'Adda (20251923), Andrew Chacon (20166765), Luca Buonanno (20251917), Carlo Fiorini (15450847), Marissa Kielly (20251926)   +8 more
core   +3 more sources

Carba‐closo‐dodecaborates as Superchaotropic Anions

Chemistry – A European Journal, EarlyView.
The singly charged boron cluster anion CB11H12– forms strong inclusion complexes with cyclodextrins, interacts strongly with nonionic polymers, and serves as an effective transmembrane carrier, positioning itself as the smallest superchaotropic anion known to date. .
Andrea Barba‐Bon, Guillermo E. Quintero, Maryam Ashjari, Ivana Nikšić‐Franjić, Kai‐Jen Tsung, Xiaojuan Wang, Margarita E. Aliaga, Bohumir Grüner, Werner M. Nau   +8 more
wiley   +1 more source

7. Neutron Capture Therapy [PDF]

, 2021
In case that corrections are made, an errata will be provided in the following webpage: https://www.rri.kyoto-u.ac.jp/PUB/report/PR/ProgRep2020/ProgRep2020.htmlCO7-1 Establichment of a novel mutation breeding using Boron Neutron Capture Reaction (BNCR ...

core