Results 31 to 40 of about 14,053 (266)

Monte Carlo assessment of boron neutron capture therapy for the treatment of breast cancer [PDF]

Nuclear Technology and Radiation Protection, 2005
For a large number of women who are diagnosed with breast cancer every year the avail able treatment options are effective, though physically and mentally taxing.
Mundy Daniel W., Jevremović Tatjana
doaj   +1 more source

Boron neutron capture therapy for newly diagnosed glioblastoma [PDF]

, 2009
PurposeThe efficacy, safety, and dose distribution of neutron capture therapy (NCT) were evaluated in 15 patients with newly diagnosed glioblastoma.Methods and materialsSeven patients received intraoperative NCT (protocol-1) and eight patients received ...
Endo Kiyoshi, Kageji Teruyoshi, Kumada Hiroaki, Matsuda Masahide, Matsumura Akira, Nakai Kei, Shibata Yasushi, Yamamoto Tetsuya, 中井 啓, 山本 哲哉, 松村 明, 柴田 靖   +11 more
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Amino Acid-Based Boron Carriers in Boron Neutron Capture Therapy (BNCT)

Pharmaceutics, 2023
Interest in the design of boronated amino acids has emerged, partly due to the utilization of boronophenylalanine (BPA), one of the two agents employed in clinical Boron Neutron Capture Therapy (BNCT).
Juulia Järvinen, Herkko Pulkkinen, Jarkko Rautio, Juri M. Timonen   +3 more
doaj   +1 more source

Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium : biological relevance and synthetic strategies [PDF]

, 2012
This review describes how the incorporation of dicarba-closo-dodecarboranes into half-sandwich complexes of ruthenium, osmium, rhodium and iridium might lead to the development of a new class of compounds with applications in medicine. Such a combination
Barry, Nicolas P. E., Sadler, P. J.
core   +1 more source

Boron delivery for boron neutron capture therapy targeting a cancer-upregulated oligopeptide transporter

Journal of Pharmacological Sciences, 2019
Boron neutron capture therapy (BNCT) is a radiotherapy utilizing the neutron capture and nuclear fission reaction of 10B taken up into tumor cells. The most commonly used boron agent in BNCT, p-borono-l-phenylalanine (BPA), is accumulated in tumors by ...
Junji Miyabe, Ryuichi Ohgaki, Keijiro Saito, Ling Wei, Lili Quan, Chunhuan Jin, Xingming Liu, Suguru Okuda, Shushi Nagamori, Hiroshi Ohki, Kazuo Yoshino, Hidenori Inohara, Yoshikatsu Kanai   +12 more
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A Dual-Beam Irradiation Facility for a Novel Hybrid Cancer Therapy

, 2012
In this paper we present the main ideas and discuss both the feasibility and the conceptual design of a novel hybrid technique and equipment for an experimental cancer therapy based on the simultaneous and/or sequential application of two beams, namely a
A Doria, A Rosen, AG Pakhomov, AR Orlando, B Born, BS Jang, C Furse, C Yu, D Satoh, DT Pooley, E Bründermann, E Giovenale, EA Nanni, G Andocs, GJ Hyland, GJ Wilmink, GJ Wilmink, H Frohlich, H Kamada, H Kamada, J Wang, JR Reimers, K Mileva, MR Scarfì, Norio Miyoshi, P Wusta, PH Siegel, R Barth, RF Barth, S Banik, S Sabchevski, S Sabchevski, Shintaro Ishiyama, Svilen Petrov Sabchevski, T Idehara, T Idehara, T Idehara, T Sato, T Tatsukawa, T Tatsukawa, T Tatsukawa, T Tatsukawa, TA Buchholz, Toshiaki Tatsukawa, Toshitaka Idehara, Y Nakagawa   +45 more
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The prospects of using IRT-T reactor experimantal facilities for boron neutron capture therapy research [PDF]

, 2012
Investigation on the use of IRT-T research reactor experimental facilities for Boron Neutron Capture Therapy (BNCT) applications was performed by calculating beam parameters at the horizontal channels' exits.
Молодов, П. А., Аникин, Михаил Николаевич, Наймушин, Артем Георгиевич   +2 more
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Localized nuclear reaction breaks boron drug capsules loaded with immune adjuvants for cancer immunotherapy

Nature Communications, 2023
Boron neutron capture therapy (BNCT) was clinically approved in 2020 and exhibits remarkable tumour rejection in preclinical and clinical studies. It is binary radiotherapy that may selectively deposit two deadly high-energy particles (4He and 7Li ...
Yaxin Shi, Zhibin Guo, Qiang Fu, Xinyuan Shen, Zhongming Zhang, Wenjia Sun, Jinqiang Wang, Junliang Sun, Zizhu Zhang, Tong Liu, Zhen Gu, Zhibo Liu   +11 more
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Investigation of irradiation conditions for recurrent breast cancer in JRR-4 [PDF]

, 2011
Clinical trials of boron neutron capture therapy (BNCT) for recurrent breast cancers are considered at Japan Research Reactor No. 4 (JRR-4). In this study, the irradiation technique for a total mastectomy patient with recurrent cancer was optimized by ...
Horiguchi H., Kumada H., Nakamura T., Sagawa H., Suzuki M., Yanagie H., 熊田 博明   +6 more
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PK Modeling of L-4-Boronophenylalanine and Development of Bayesian Predictive Platform for L-4-Boronophenylalanine PKs for Boron Neutron Capture Therapy

Pharmaceuticals
L-4-[(10B)]Boronophenylalanine (BPA) is an amino acid analogue with a boron-10 moiety. It is most widely used as a boron carrier in boron neutron capture therapy.
Woohyoung Kim, Ji Yeong Won, Jungyu Yi, Seung Chan Choi, Sang Min Lee, Kyungran Mun, Hyeong-Seok Lim   +6 more
doaj   +1 more source