Results 1 to 10 of about 3,740,560 (195)

Amino Acid-Based Boron Carriers in Boron Neutron Capture Therapy (BNCT). [PDF]

Pharmaceutics, 2023
Interest in the design of boronated amino acids has emerged, partly due to the utilization of boronophenylalanine (BPA), one of the two agents employed in clinical Boron Neutron Capture Therapy (BNCT). The boronated amino acids synthesized thus far for BNCT investigations can be classified into two categories based on the source of boron: boronic acids
Järvinen J, Pulkkinen H, Rautio J, Timonen JM.   +3 more
europepmc   +5 more sources

Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma. [PDF]

Int J Mol Sci, 2023
Meningiomas are the most frequently diagnosed primary intracranial tumors in adults. Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control.
Lan TL, Lin CF, Lee YY, Lin KH, Chang FC, Lin SC, Lee JC, Chou FI, Peir JJ, Liu HM, Mu PF, Chen YW.   +11 more
europepmc   +4 more sources

Optimizing Boron Neutron Capture Therapy (BNCT) to Treat Cancer: An Updated Review on the Latest Developments on Boron Compounds and Strategies. [PDF]

Cancers (Basel), 2023
Optimizing Boron Neutron Capture Therapy (BNCT) to Treat Cancer: An Updated Review on the Latest Developments on Boron Compounds and StrategiesAndrea Monti Hughes 1 2, Naonori Hu 3 4Affiliations1Radiation Pathology Division, Department Radiobiology ...
Monti Hughes A, Hu N.
europepmc   +4 more sources

Chordoma Treatment with Boron Neutron Capture Therapy (BNCT): Experimental Insights

Proceedings
Boron Neutron Capture Therapy (BNCT) is a particle beam therapy that enables the precise targeting of tumors at the cellular level [...]
Yoshiki Fujikawa, Shinji Kawabata, Kohei Tsujino, Hideki Kashiwagi, Yusuke Fukuo, Ryo Hiramatsu, Hiroki Tanaka, Naonori Hu, Toshihiro Takami, Masahiko Wanibuchi   +9 more
doaj   +4 more sources

Quantification of ¹⁰B and ¹¹B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT). [PDF]

Med Res Rev
ABSTRACT Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low‐energy neutrons to induce high linear energy transfer particles with short path lengths, resulting in localized tumor cell destruction while sparing surrounding healthy ...
Selg C, Sauerwein WAG, Hey-Hawkins E.
europepmc   +2 more sources

Safety, efficacy, pharmacokinetics, and mechanisms of novel ¹⁰B-boronophenylalanine combined with a radio-frequency quadrupole accelerator in boron neutron capture therapy: A preclinical study in head and neck squamous cell carcinoma. [PDF]

Precis Radiat Oncol
This study demonstrates that the novel 10B‐BPA‐based BNCT system, combined with an RFQ accelerator, effectively targets head and neck squamous cell carcinoma. It induces tumor regression safely and efficiently by triggering DNA damage and activating the ROS/HIF‐1α/NF‐κB pathway, leading to caspase‐3‐mediated apoptosis.
Zhang Z, Li J, Fan M, Ouyang H, Chu Q, Yan H, Zheng Y, Huang L, Bao G, Ma Z, Huang S, Li L, Xu X, Liu Z.   +13 more
europepmc   +2 more sources

Transporter-Associated Therapeutic Efficacy of an SMVT-Targeted Boron Carrier in Boron Neutron Capture Therapy. [PDF]

Cancer Sci
The transporter‐associated BNCT strategy using BBCIP with or without BPA according to tumor transporter characteristics. BPA showed greater efficacy in LAT1‐dominant F98 glioma, whereas BBCIP was more effective in SMVT‐high CRL1666 tumors, suggesting the potential utility of transporter‐based boron carrier selection in BNCT.
Eza K, Tsujino K, Shidoh-Kazuki R, Fujikawa Y, Kashiwagi H, Futamura G, Hiramatsu R, Takami T, Wanibuchi M, Hu N, Tanaka H, Suzuki M, Nishimura K, Tanaka S, Nakamura H, Kawabata S.   +15 more
europepmc   +2 more sources

Microdosimetry in BNCT [PDF]

Precis Radiat Oncol
Precision Radiation Oncology, EarlyView.
Santa Cruz G.
europepmc   +2 more sources

Exploring the Biological and Physical Basis of Boron Neutron Capture Therapy (BNCT) as a Promising Treatment Frontier in Breast Cancer. [PDF]

Cancers (Basel), 2022
Seneviratne D, Advani P, Trifiletti DM, Chumsri S, Beltran CJ, Bush AF, Vallow LA.   +6 more
europepmc   +2 more sources

In Vivo Application of Carboranes for Boron Neutron Capture Therapy (BNCT): Structure, Formulation and Analytical Methods for Detection. [PDF]

Cancers (Basel), 2023
Marforio TD, Carboni A, Calvaresi M.
europepmc   +2 more sources