Results 31 to 40 of about 5,439 (211)

First Attempt of Boron Neutron Capture Therapy (BNCT) for Hepatocellular Carcinoma [PDF]

Japanese Journal of Clinical Oncology, 2007
A 60-year-old man with multiple hepatocellular carcinomas (HCCs) was enrolled as the first patient in a pilot study for treating multiple liver tumors with boron neutron capture therapy (BNCT). Because of compromised liver function, the multiple tumors in the right liver lobe were treated with BNCT and those in the left lobe with hepatic arterial ...
Minoru, Suzuki, Yoshinori, Sakurai, Satoru, Hagiwara, Shinichiro, Masunaga, Yuko, Kinashi, Kenji, Nagata, Akira, Maruhashi, Masatoshi, Kudo, Koji, Ono   +8 more
openaire   +2 more sources

Clinical trials for treating recurrent head and neck cancer with boron neutron capture therapy using the Tsing-Hua Open Pool Reactor

Cancer Communications, 2018
Head and neck (HN) cancer is an endemic disease in Taiwan, China. Locally recurrent HN cancer after full-dose irradiation poses a therapeutic challenge, and boron neutron capture therapy (BNCT) may be a solution that could provide durable local control ...
Ling-Wei Wang, Yen-Wan Hsueh Liu, Fong-In Chou, Shiang-Huei Jiang   +3 more
doaj   +1 more source

Polymers and boron neutron capture therapy (BNCT): a potent combination

Polymer Chemistry, 2021
This review describes the latest polymeric systems used as boron transporters for boron neutron capture therapy.
openaire   +3 more sources

Enhancement of dose distribution using tissue compensators in boron neutron capture therapy. [PDF]

J Appl Clin Med Phys
Abstract In BNCT for head and neck tumors delivered with a horizontal beam, the presence of missing tissue near the beam path can cause reduction in neutron fluence rate in adjacent tissue regions due to the loss of scattered neutrons. These regions are referred to as neutron depleted areas.
Sasaki A, Hu N, Nojiri M, Akita K, Yoshikawa S, Kohigashi Y, Nihei K, Aihara T, Takeno S, Yoshino Y, Tanaka H, Ono K.   +11 more
europepmc   +2 more sources

Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium : biological relevance and synthetic strategies [PDF]

, 2012
This review describes how the incorporation of dicarba-closo-dodecarboranes into half-sandwich complexes of ruthenium, osmium, rhodium and iridium might lead to the development of a new class of compounds with applications in medicine. Such a combination
Barry, Nicolas P. E., Sadler, P. J.
core   +1 more source

Boron delivery for boron neutron capture therapy targeting a cancer-upregulated oligopeptide transporter

Journal of Pharmacological Sciences, 2019
Boron neutron capture therapy (BNCT) is a radiotherapy utilizing the neutron capture and nuclear fission reaction of 10B taken up into tumor cells. The most commonly used boron agent in BNCT, p-borono-l-phenylalanine (BPA), is accumulated in tumors by ...
Junji Miyabe, Ryuichi Ohgaki, Keijiro Saito, Ling Wei, Lili Quan, Chunhuan Jin, Xingming Liu, Suguru Okuda, Shushi Nagamori, Hiroshi Ohki, Kazuo Yoshino, Hidenori Inohara, Yoshikatsu Kanai   +12 more
doaj   +1 more source

A Dual-Beam Irradiation Facility for a Novel Hybrid Cancer Therapy

, 2012
In this paper we present the main ideas and discuss both the feasibility and the conceptual design of a novel hybrid technique and equipment for an experimental cancer therapy based on the simultaneous and/or sequential application of two beams, namely a
A Doria, A Rosen, AG Pakhomov, AR Orlando, B Born, BS Jang, C Furse, C Yu, D Satoh, DT Pooley, E Bründermann, E Giovenale, EA Nanni, G Andocs, GJ Hyland, GJ Wilmink, GJ Wilmink, H Frohlich, H Kamada, H Kamada, J Wang, JR Reimers, K Mileva, MR Scarfì, Norio Miyoshi, P Wusta, PH Siegel, R Barth, RF Barth, S Banik, S Sabchevski, S Sabchevski, Shintaro Ishiyama, Svilen Petrov Sabchevski, T Idehara, T Idehara, T Idehara, T Sato, T Tatsukawa, T Tatsukawa, T Tatsukawa, T Tatsukawa, TA Buchholz, Toshiaki Tatsukawa, Toshitaka Idehara, Y Nakagawa   +45 more
core   +1 more source

Investigation of irradiation conditions for recurrent breast cancer in JRR-4 [PDF]

, 2011
Clinical trials of boron neutron capture therapy (BNCT) for recurrent breast cancers are considered at Japan Research Reactor No. 4 (JRR-4). In this study, the irradiation technique for a total mastectomy patient with recurrent cancer was optimized by ...
Horiguchi H., Kumada H., Nakamura T., Sagawa H., Suzuki M., Yanagie H., 熊田 博明   +6 more
core   +1 more source

Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT

Frontiers in Chemistry, 2021
Boron clusters attract considerable attention as promising therapeutic tools for boron neutron capture therapy (BNCT). They combine high boron content with high chemical and biological stability, biorthogonality, and low toxicity.
Darya Sergeevna Novopashina, Mariya Alexandrovna Vorobyeva, Alya Venyaminova   +2 more
doaj   +1 more source

Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma [PDF]

, 2009
Background Boron neutron capture therapy (BNCT) is a selective radiotherapy, being effective for the treatment of even advanced malignancies in head and neck regions as well as brain tumors and skin melanomas.
Yusei Fujita, Itsuro Kato, Soichi Iwai, Koji Ono, Minoru Suzuki, Yoshinori Sakurai, Ken Ohnishi, Takeo Ohnishi, Yoshiaki Yura   +8 more
core   +1 more source