Results 51 to 60 of about 14,053 (266)

Efficacy of Boron Neutron Capture Therapy in Primary Central Nervous System Lymphoma: In Vitro and In Vivo Evaluation

Cells, 2021
Background: Boron neutron capture therapy (BNCT) is a nuclear reaction-based tumor cell-selective particle irradiation method. High-dose methotrexate and whole-brain radiation therapy (WBRT) are the recommended treatments for primary central nervous ...
Kohei Yoshimura, Shinji Kawabata, Hideki Kashiwagi, Yusuke Fukuo, Koji Takeuchi, Gen Futamura, Ryo Hiramatsu, Takushi Takata, Hiroki Tanaka, Tsubasa Watanabe, Minoru Suzuki, Naonori Hu, Shin-Ichi Miyatake, Masahiko Wanibuchi   +13 more
doaj   +1 more source

Boron carbide nanoparticles for boron neutron capture therapy. [PDF]

RSC Adv
Boron carbide nanoparticles were chemically modified with folic acid conjugated via PEG linkers, achieving tumor boron levels up to 50 μg g −1 dried tissue 24 h post-injection.
Xu S, Yu Y, Zhang B, Zhu K, Cheng Y, Zhang T.   +5 more
europepmc   +3 more sources

Quantification of 10B and 11B in Biological Samples in Translational Science and Clinical Applications for Boron Neutron Capture Therapy (BNCT)

Medicinal Research Reviews, EarlyView.
ABSTRACT Boron neutron capture therapy (BNCT) is a targeted radiotherapy that exploits the selective accumulation of the 10B isotope within tumors, followed by irradiation with low‐energy neutrons to induce high linear energy transfer particles with short path lengths, resulting in localized tumor cell destruction while sparing surrounding healthy ...
Christoph Selg, Wolfgang A. G. Sauerwein, Evamarie Hey‐Hawkins   +2 more
wiley   +1 more source

The current status of bnct facility at the IRT-T research reactor [PDF]

, 2017
Investigation on the use of the IRT-T research reactor as a neutron source for Boron Neutron Capture Therapy (BNCT) has been performed by calculating «in air» parameters at the HEC-1 exit.
Аникин, Михаил Николаевич, Молодов, П. А., Наймушин, Артем Георгиевич   +2 more
core  

Boron neutron capture therapy induces cell cycle arrest and cell apoptosis of glioma stem/progenitor cells in vitro [PDF]

, 2013
BACKGROUND: Glioma stem cells in the quiescent state are resistant to clinical radiation therapy. An almost inevitable glioma recurrence is due to the persistence of these cells.
Bin Li, Guilin Chen, Jie Wu, Ting Sun, Xueshun Xie, Yongxin Wei, Youxin Zhou, Ziwei Du, Zizhu Zhang   +8 more
core   +1 more source

When Fat Goes Astray: Your Liver and Pancreas Get Into Trouble

Portal Hypertension &Cirrhosis, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) and intrapancreatic fat deposition (IPFD) are both common manifestations of ectopic fat accumulation. Although they share multiple risk factors, they also show notable differences in pathological features, standardization of diagnosis, and research maturity.
Yuying Chen, Li Ding, Shan Zhao, Weihong Wang, Jing Zhong, Qiang Yan   +5 more
wiley   +1 more source

Acral cutaneous malignant melanoma treated with linear accelerator-based boron neutron capture therapy system: a case report of first patient

Frontiers in Oncology, 2023
This study reports the first patient treatment for cutaneous malignant melanoma using a linear accelerator-based boron neutron capture therapy (BNCT) system.
Hiroshi Igaki, Hiroshi Igaki, Satoshi Nakamura, Satoshi Nakamura, Satoshi Nakamura, Naoya Yamazaki, Tomoya Kaneda, Mihiro Takemori, Mihiro Takemori, Tairo Kashihara, Tairo Kashihara, Naoya Murakami, Naoya Murakami, Kenjiro Namikawa, Tetsu Nakaichi, Hiroyuki Okamoto, Kotaro Iijima, Kotaro Iijima, Takahito Chiba, Takahito Chiba, Hiroki Nakayama, Hiroki Nakayama, Ayaka Nagao, Madoka Sakuramachi, Kana Takahashi, Koji Inaba, Kae Okuma, Yuko Nakayama, Kazuaki Shimada, Hitoshi Nakagama, Jun Itami, Jun Itami   +31 more
doaj   +1 more source

10B Concentration, Phantom Size and Tumor Location Dependent Dose Enhancement and Neutron Spectra in Boron Neutron Capture Therapy [PDF]

Journal of Biomedical Physics and Engineering, 2019
Background: The amount of average dose enhancement in tumor loaded with 10B may vary due to various factors in boron neutron capture therapy.Objective: This study aims to evaluate dose enhancement in tumor loaded with 10B under influence of various ...
Gh Izadi Vasafi, M M Firoozabadi
doaj   +1 more source

MAGIC polymer gel for dosimetric verification in boron neutron capture therapy [PDF]

, 2007
"Radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools developed to date. We tested the normoxic polymer gel dosimeter known by the acronym MAGIC (methacrylic and ascorbic acid in gelatin initiated by ...
Aschan, Auterinen, Auterinen, Chu, Chu, Deene, Deene, Farajollahi, Fong, Fransson, Gambarini, Gambarini, Gambarini, Gambarini, Gore, Gustavsson, Gustavsson, Gustavsson, Heufelder, Iiro Auterinen, International Commission on Radiation Units and Measurements (ICRU), Jirasek, Jouni Uusi-Simola, Kosunen, Low, Maryanski, Petri Kotiluoto, Press, Raaijmakers, Rae, Ramm, Rogus, Sami Heikkinen, Sauli Savolainen, Seppälä, Serén, Silva, Tiina Seppälä, Tom Serén, Uusi-Simola   +39 more
core   +1 more source

Boron‐10 carriers and their applications in boron neutron capture therapy

Precision Radiation Oncology, EarlyView.
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu   +7 more
wiley   +1 more source