Results 21 to 30 of about 6,494 (198)

Boron‐embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma [PDF]

Smart Mol
A brain‐targeting multifunctional nanoplatform (DM&Ce6@COF‐Ang) was engineered by employing boron‐enriched APTES‐COF‐1 as both the therapeutic boron agent and the nanocarrier co‐delivery of DMXAA and Ce6. This nanoplatform achieved synergistic tumor‐specific boron delivery, real‐time pharmacokinetic monitoring, and immunomodulation.
Liu Y, Wang X, Li B, Shao K, Su J, Wang Y, Cheng L, Wu Z, Li J, Zhang G, Wang X, Zhang Y, Liu Y, Li G.   +13 more
europepmc   +2 more sources

Bystander and abscopal effects of boron neutron capture therapy: radiobiological mechanisms and immunotherapeutic strategies [PDF]

Frontiers in Oncology
Boron neutron capture therapy (BNCT) is a high–linear energy transfer radiotherapy that enables cell-scale selective tumor killing and has shown clinical potential in recurrent and radioresistant cancers.
Zizhu Zhang, Chunyuan Zhao, Yizheng Chong, Longmin Li, Xiayang Zhu, Yujun Shao   +5 more
doaj   +2 more sources

Clinical outcomes of boron neutron capture therapy for unresectable oral cancer: a retrospective analysis [PDF]

Frontiers in Oncology
BackgroundSurgery is the standard treatment for oral cancer but often causes functional and cosmetic problems, and reoperation is difficult. Radiotherapy (RT) is less effective, with reirradiation limited by normal tissue tolerance and salvage surgery ...
Yuki Yoshino, Yuki Yoshino, Yuki Yoshino, Satoshi Takeno, Satoshi Takeno, Teruhito Aihara, Teruhito Aihara, Naonori Hu, Naonori Hu, Akinori Sasaki, Kazuhiko Akita, Yasukazu Kanai, Yasukazu Kanai, Mai Nojiri, Tsuyoshi Jinnin, Tetsuya Terada, Shinichi Haginomori, Keiji Nihei, Keiji Nihei, Koji Ono, Koji Ono   +20 more
doaj   +2 more sources

Advances in Clinical Trials of Boron Neutron Capture Therapy [PDF]

Research
Boron neutron capture therapy (BNCT) is a targeted radiotherapy technique that enables dual targeting at the physico-biological level. Efficient neutron sources and specific boron carriers are essential for successful treatment. By exploiting the 10B(n,α)
Xiaoling Li, Zhijie Liu, Kejun Liu, Chunhong Wang, Zhigang Liu, Xiao Xu   +5 more
doaj   +2 more sources

Dose-Dependent Suppression of Human Glioblastoma Xenograft Growth by Accelerator-Based Boron Neutron Capture Therapy with Simultaneous Use of Two Boron-Containing Compounds

Biology, 2021
(1) Background: Developments in accelerator-based neutron sources moved boron neutron capture therapy (BNCT) to the next phase, where new neutron radiation parameters had to be studied for the treatment of cancers, including brain tumors.
Vladimir Kanygin, Ivan Razumov, Alexander Zaboronok, Evgenii Zavjalov, Aleksandr Kichigin, Olga Solovieva, Alphiya Tsygankova, Tatiana Guselnikova, Dmitrii Kasatov, Tatiana Sycheva, Bryan J. Mathis, Sergey Taskaev   +11 more
doaj   +1 more source

Enhancement in the Therapeutic Efficacy of In Vivo BNCT Mediated by GB-10 with Electroporation in a Model of Oral Cancer

Cells, 2023
Boron neutron capture therapy (BNCT) combines preferential tumor uptake of 10B compounds and neutron irradiation. Electroporation induces an increase in the permeability of the cell membrane.
Nahuel Olaiz, Andrea Monti Hughes, Emiliano C. C. Pozzi, Silvia Thorp, Paula Curotto, Verónica A. Trivillin, Paula S. Ramos, Mónica A. Palmieri, Guillermo Marshall, Amanda E. Schwint, Marcela A. Garabalino   +10 more
doaj   +1 more source

Response of Normal Tissues to Boron Neutron Capture Therapy (BNCT) with ¹⁰B-Borocaptate Sodium (BSH) and ¹⁰B-Paraboronophenylalanine (BPA)

Cells, 2021
Boron neutron capture therapy (BNCT) is a cancer-selective radiotherapy that utilizes the cancer targeting 10B-compound. Cancer cells that take up the compound are substantially damaged by the high liner energy transfer (LET) particles emitted mainly ...
Hiroshi Fukuda
doaj   +1 more source

Optimising neutron production from compact low energy accelerators [PDF]

, 2012
There is currently much development in accelerator based methods to provide flexible and reliable neutron generators, in response to a decline in the availability of nuclear reactors.
Cywinski, Robert, Bungau, Adriana, Edgecock, R., Ratcliffe, N, Barlow, Roger   +4 more
core   +3 more sources

Utilização de poli(glicerol) dendrítico como transportador de cianocobalamina borilada para utilização na bnct [PDF]

, 2021
The present work describes the synthesis and characterization of the poly (glycerol) and bored B12 vitamin (CbI-BPA/PGLDG4) conjugated. Such conjugated was conceived with focus on its utilization in the Boron Neutron Capture Therapy (BNCT), a ...
REAL, Letícia Silvério
core   +1 more source

Experimental terminal design of BNCT neutron source based on 14 MeV proton cyclotron

He jishu, 2022
BackgroundWith the development of accelerator technology, the accelerator-based Boron Neutron Capture Therapy (BNCT) has attracted more and more attention, and metallic 9Be is one of the most suitable materials for neutron-producing targets.PurposeThe ...
LU Yu, LI Wenyi, XU Zhao, LI Taosheng
doaj   +1 more source