Results 21 to 30 of about 2,170 (170)
Cells, 2023 Boron neutron capture therapy (BNCT) combines preferential tumor uptake of 10B compounds and neutron irradiation. Electroporation induces an increase in the permeability of the cell membrane.
Nahuel Olaiz +10 more
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Cells, 2021 Boron neutron capture therapy (BNCT) is a cancer-selective radiotherapy that utilizes the cancer targeting 10B-compound. Cancer cells that take up the compound are substantially damaged by the high liner energy transfer (LET) particles emitted mainly ...
Hiroshi Fukuda
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Emerging agents for boron neutron capture therapy: Biomolecular carriers paving the way for precision radiotherapy [PDF]
Precis Radiat OncolBoron neutron capture therapy (BNCT) requires key non‐negotiable technical criteria: megadose administration, precise tumor‐specific targeting, favorable biocompatibility, and sustained tumor retention. Overcoming these interconnected challenges fundamentally depends on biomolecular carriers, which are critical for translating the therapeutic potential
Chen C +6 more
europepmc +2 more sources
Boron‐10 carriers and their applications in boron neutron capture therapy [PDF]
Precis Radiat OncolSummary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Tang D +7 more
europepmc +2 more sources
Combined BNCT and PET for theranostics
Bio-Algorithms and Med-Systems, 2021 Abstract This short review summarizes the issue of boron distribution monitoring in boron neutron capture therapy (BNCT), which remains a serious drawback of this powerful oncological treatment. Here we present the monitoring methods that are presently used with particular emphasis on the positron emission tomography (PET) which has the ...
Silarski, Michał +2 more
openaire +2 more sources
Scientific Reports, 2023 Boron neutron capture therapy (BNCT) is a high-LET particle radiotherapy clinically tested for treating malignant gliomas. Boronophenylalanine (BPA), a boron-containing phenylalanine derivative, is selectively transported into tumor cells by amino acid ...
Masao Fukumura +15 more
doaj +1 more source
Carborane Polypeptide Derivatives for Boron Neutron Capture Therapy
He huaxue yu fangshe huaxue, 2023 The design and application of carborane polypeptide derivatives have attracted more and more attention, especially as boron carrier in the treatment of malignant tumors(BNCT).
HAN Yi, LI Feng-lin, LUO Zhi-fu
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Experimental terminal design of BNCT neutron source based on 14 MeV proton cyclotron
He jishu, 2022 BackgroundWith the development of accelerator technology, the accelerator-based Boron Neutron Capture Therapy (BNCT) has attracted more and more attention, and metallic 9Be is one of the most suitable materials for neutron-producing targets.PurposeThe ...
LU Yu, LI Wenyi, XU Zhao, LI Taosheng
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Application and Development of Tumor-Targeting Boron Carriers in Boron Neutron Capture Therapy
He huaxue yu fangshe huaxue, 2023 Boron neutron capture therapy(BNCT) is a promising therapeutic method for malignant tumors and has entered the clinical trials. As a binary cellular accurate therapy, BNCT relies on tumor-targeting boron delivery.
CHEN Kui, LYU Lin-wen, XING Geng-mei
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Advances in boron neutron capture therapy (BNCT) at kyoto university - From reactor-based BNCT to accelerator-based BNCT [PDF]
Journal of the Korean Physical Society, 2015 At the Kyoto University Research Reactor Institute (KURRI), a clinical study of boron neutron capture therapy (BNCT) using a neutron irradiation facility installed at the research nuclear reactor has been regularly performed since February 1990. As of November 2014, 510 clinical irradiations were carried out using the reactor-based system.
Sakurai, Yoshinori +12 more
openaire +1 more source