Results 21 to 30 of about 8,497 (207)

Enhancement in the Therapeutic Efficacy of In Vivo BNCT Mediated by GB-10 with Electroporation in a Model of Oral Cancer

Cells, 2023
Boron neutron capture therapy (BNCT) combines preferential tumor uptake of 10B compounds and neutron irradiation. Electroporation induces an increase in the permeability of the cell membrane.
Nahuel Olaiz, Andrea Monti Hughes, Emiliano C. C. Pozzi, Silvia Thorp, Paula Curotto, Verónica A. Trivillin, Paula S. Ramos, Mónica A. Palmieri, Guillermo Marshall, Amanda E. Schwint, Marcela A. Garabalino   +10 more
doaj   +1 more source

Response of Normal Tissues to Boron Neutron Capture Therapy (BNCT) with ¹⁰B-Borocaptate Sodium (BSH) and ¹⁰B-Paraboronophenylalanine (BPA)

Cells, 2021
Boron neutron capture therapy (BNCT) is a cancer-selective radiotherapy that utilizes the cancer targeting 10B-compound. Cancer cells that take up the compound are substantially damaged by the high liner energy transfer (LET) particles emitted mainly ...
Hiroshi Fukuda
doaj   +1 more source

Enhancement of dose distribution using tissue compensators in boron neutron capture therapy. [PDF]

J Appl Clin Med Phys
Abstract In BNCT for head and neck tumors delivered with a horizontal beam, the presence of missing tissue near the beam path can cause reduction in neutron fluence rate in adjacent tissue regions due to the loss of scattered neutrons. These regions are referred to as neutron depleted areas.
Sasaki A, Hu N, Nojiri M, Akita K, Yoshikawa S, Kohigashi Y, Nihei K, Aihara T, Takeno S, Yoshino Y, Tanaka H, Ono K.   +11 more
europepmc   +2 more sources

5-Aminolevulinic acid increases boronophenylalanine uptake into glioma stem cells and may sensitize malignant glioma to boron neutron capture therapy

Scientific Reports, 2023
Boron neutron capture therapy (BNCT) is a high-LET particle radiotherapy clinically tested for treating malignant gliomas. Boronophenylalanine (BPA), a boron-containing phenylalanine derivative, is selectively transported into tumor cells by amino acid ...
Masao Fukumura, Naosuke Nonoguchi, Shinji Kawabata, Ryo Hiramatsu, Gen Futamura, Koji Takeuchi, Takuya Kanemitsu, Takushi Takata, Hiroki Tanaka, Minoru Suzuki, Oltea Sampetrean, Naokado Ikeda, Toshihiko Kuroiwa, Hideyuki Saya, Ichiro Nakano, Masahiko Wanibuchi   +15 more
doaj   +1 more source

Experimental terminal design of BNCT neutron source based on 14 MeV proton cyclotron

He jishu, 2022
BackgroundWith the development of accelerator technology, the accelerator-based Boron Neutron Capture Therapy (BNCT) has attracted more and more attention, and metallic 9Be is one of the most suitable materials for neutron-producing targets.PurposeThe ...
LU Yu, LI Wenyi, XU Zhao, LI Taosheng
doaj   +1 more source

Epithermal Neutron Beam Interference with Cardiac Pacemakers [PDF]

, 2010
Peer ...
Auterinen, Iiro, Hyvönen, H., Iivonen, P., Kankaanranta, L., Koivunoro, H., Kotiluoto, Petri, Pakarinen, S., Savolainen, S., Seppälä, T., Serén, Tom, Tenhunen, M.   +10 more
core   +1 more source

Application and Development of Tumor-Targeting Boron Carriers in Boron Neutron Capture Therapy

He huaxue yu fangshe huaxue, 2023
Boron neutron capture therapy(BNCT) is a promising therapeutic method for malignant tumors and has entered the clinical trials. As a binary cellular accurate therapy, BNCT relies on tumor-targeting boron delivery.
CHEN Kui, LYU Lin-wen, XING Geng-mei
doaj   +1 more source

Dicarba-closo-dodecarborane-containing half-sandwich complexes of ruthenium, osmium, rhodium and iridium : biological relevance and synthetic strategies [PDF]

, 2012
This review describes how the incorporation of dicarba-closo-dodecarboranes into half-sandwich complexes of ruthenium, osmium, rhodium and iridium might lead to the development of a new class of compounds with applications in medicine. Such a combination
Barry, Nicolas P. E., Sadler, P. J.
core   +1 more source

Carborane Polypeptide Derivatives for Boron Neutron Capture Therapy

He huaxue yu fangshe huaxue, 2023
The design and application of carborane polypeptide derivatives have attracted more and more attention, especially as boron carrier in the treatment of malignant tumors(BNCT).
HAN Yi, LI Feng-lin, LUO Zhi-fu
doaj   +1 more source

The Birmingham Boron Neutron Capture Therapy (BNCT) project : developments towards selective internal particle therapy [PDF]

, 2011
This paper will review progress on two aspects of the Birmingham BNCT project. Firstly on evaluation of the effects of high and low LET radiations when delivered simultaneously, and secondly on attempts to optimise delivery of the boron carrier compound ...
Boddy, A., Charles, M. W., Croswell, G., Cruickshank, G. S., Detta, A., Doran, J., Elliott, M., Ford, S., Ghani, Z., Graham, N., Green, S., Halbert, G., Hill, M., James, N. D., Jones, B., King, A., Lockyer, N., Mill, A. J., Ngoga, D., Phoenix, B., Sheehan, T. M. T., Thompson, J., Vickerman, J., Wojnecki, C.   +23 more
core   +1 more source