Results 41 to 50 of about 1,302 (169)

Recent Advances in Site‐ and Stereocontrolled Selective Light‐Mediated Functionalizations of Monosaccharide Derivatives

ChemPhotoChem, Volume 10, Issue 10, October 2026.
Once regarded as highly reactive and difficult‐to‐control intermediates, monosaccharide‐derived radicals have emerged as powerful tools for selective synthesis. This review highlights how modern photocatalytic strategies enable the controlled generation of these radicals and their highly regio‐ and stereoselective transformation into structurally ...
Corentin Lefebvre, Norbert Hoffmann
wiley   +1 more source

Summary of in vitro antiviral properties of iminosugars.

, 2016
Summary of in vitro antiviral properties of iminosugars.
Eva Harris (27355), Alessandro T. Caputo (3180210), Kyoko Kinami (1608367), P. Robert Beatty (253230), Sarah S. Killingbeck (3180222), Michelle L. Hill (329880), Joanna L. Miller (3180228), Beatrice E. Tyrrell (3180219), Nicole Zitzmann (90474), Atsushi Kato (264067), J. L. Kiappes (2178494), Andrew C. Sayce (3180216), Ren Iwaki (3180213), Raymond A. Dwek (156053), Daisuke Ide (3180225), Dominic S. Alonzi (1297545)   +15 more
core   +1 more source

Low-generation dendrimers with a calixarene core and based on a chiral C2-symmetric pyrrolidine as iminosugar mimics

Beilstein Journal of Organic Chemistry, 2012
The preparation of low-generation dendrimers based on a simple calix[4]arene scaffold by insertion of the iminosugar-analogue C2-symmetric 3,4-dihydroxypyrrolidine is described.
Marco Marradi, Stefano Cicchi, Francesco Sansone, Alessandro Casnati, Andrea Goti   +4 more
doaj   +1 more source

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source

Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. Compounds are comprised of three key structural motifs: the iminosugar, for interaction with cholinesterase catalytic anionic site (
Ana I. Ahuja-Casarín, Penélope Merino-Montiel, José Luis Vega-Baez, Sara Montiel-Smith, Miguel X. Fernandes, Irene Lagunes, Inés Maya, José M. Padrón, Óscar López, José G. Fernández-Bolaños   +9 more
doaj   +1 more source

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

Chemistry – A European Journal, Volume 32, Issue 29, 7 August 2026.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow, Oscar L. Alferez, David L. Jakeman   +2 more
wiley   +1 more source

Synthesis of N-Alkylated L-Iminosugars and their Therapeutic Application in Cystic Fibrosis Lung Disease

, 2018
Iminosugars represent the most promising class of therapeutically useful glycomimetics. Because of their ability to mimic structure and properties of natural monosaccharides, iminosugars are able to interfere with disease-related carbohydrate-processing ...
Munari, S., Gambari, R., Lippi, G., Esposito, Anna., Lampronti, I., Santangelo, A., De Fenza, Maria., De Fino, I., Dechecchi, M. C., D'Alonzo, Daniele., Loberto, N., Sonnino, A., Guaragna, A., Aureli, M., Cabrini, G., Rossi, A., Ranucci, S., Bragonzi, A., Tamanini, A.   +18 more
core   +1 more source

A Convenient Approach towards the Synthesis of ADMDP Type Iminosugars and Nojirimycin Derivatives from Sugar-Derived Lactams

Molecules, 2021
An efficient method for the synthesis of nojirimycin- and pyrrolidine-based iminosugar derivatives has been developed. The strategy is based on the partial reduction in sugar-derived lactams by Schwartz’s reagent and tandem stereoselective nucleophilic ...
Piotr Szcześniak, Barbara Grzeszczyk, Bartłomiej Furman   +2 more
doaj   +1 more source

Synthetic Ligands of Myeloid C‐Type Lectin Receptors

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Binding of ligands to C‐type lectin receptors (CLRs) on myeloid cells can lead to an array of cellular responses. Exploitation of these receptors for therapeutic purposes requires high‐affinity ligands. This review surveys the diversity of synthetic ligands of myeloid CLRs in the context of binding, signaling, and downstream effects, as well as ...
James Suri, Bernd Lepenies
wiley   +1 more source

Lithium Diisopropylamide‐Mediated Ring‐Opening of Tetrahydrofuran in the Synthesis of Polyhydroxylated Indolizidines

European Journal of Organic Chemistry, Volume 29, Issue 24, 23 June 2026.
Chiral tri‐ and pentahydroxy spirocyclopentane‐indolizidines were synthesized using lithium diisopropylamide “LDA” promoted diallylation and tetrahydrofuran “THF” ring‐opening in a one‐pot procedure as a key step. The sequence leading to the targeted hydroxy‐spiroindolizidines was achieved by cis‐dihydroxylation followed by reduction of the enamine and
Paula Fraňová, Peter Šafář, Marchalín Štefan, Petra Pažitná, Ivana Žídeková, Ján Moncol, Adam Daïch   +6 more
wiley   +1 more source