Results 51 to 60 of about 1,302 (169)

In vitro enzyme inhibition of iminosugars.

, 2016
In vitro enzyme inhibition of iminosugars.
Eva Harris (27355), Alessandro T. Caputo (3180210), Kyoko Kinami (1608367), P. Robert Beatty (253230), Sarah S. Killingbeck (3180222), Michelle L. Hill (329880), Joanna L. Miller (3180228), Beatrice E. Tyrrell (3180219), Nicole Zitzmann (90474), Atsushi Kato (264067), J. L. Kiappes (2178494), Andrew C. Sayce (3180216), Ren Iwaki (3180213), Raymond A. Dwek (156053), Daisuke Ide (3180225), Dominic S. Alonzi (1297545)   +15 more
core   +1 more source

Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar

Beilstein Journal of Organic Chemistry, 2015
The synthesis of new multivalent architectures based on a trihydroxypiperidine α-fucosidase inhibitor is reported herein. Tetravalent and nonavalent dendrimers were obtained by means of the click chemistry approach involving the copper azide-alkyne ...
Camilla Matassini, Stefania Mirabella, Andrea Goti, Inmaculada Robina, Antonio J. Moreno-Vargas, Francesca Cardona   +5 more
doaj   +1 more source

Electrophilic Iodination of Heterocyclic Compounds. Recent Advances 2008–2025: Part II

European Journal of Organic Chemistry, Volume 29, Issue 22, 9 June 2026.
Electrophilic iodination using molecular iodine and iodide sources represents an efficient approach for accessing valuable iodinated organic compounds. This review highlights recent advances in the iodination of heterocyclic compounds from 2008 to 2025, emphasizing the role of heteroaryl iodides as important synthetic intermediates for biologically ...
Njomza Ajvazi, Stojan Stavber
wiley   +1 more source

Iminosugars used in this study.

, 2016
Iminosugars are sugar mimics with nitrogen substitution of the endocyclic oxygen. Sugars from which iminosugars are derived are presented to the left with d-glucose on top (white background) and d-galactose on the bottom (grey background).
Eva Harris (27355), Alessandro T. Caputo (3180210), Kyoko Kinami (1608367), P. Robert Beatty (253230), Sarah S. Killingbeck (3180222), Michelle L. Hill (329880), Joanna L. Miller (3180228), Beatrice E. Tyrrell (3180219), Nicole Zitzmann (90474), Atsushi Kato (264067), J. L. Kiappes (2178494), Andrew C. Sayce (3180216), Ren Iwaki (3180213), Raymond A. Dwek (156053), Daisuke Ide (3180225), Dominic S. Alonzi (1297545)   +15 more
core   +1 more source

Borylated 5-Membered Ring Iminosugars: Detailed Nuclear Magnetic Resonance Spectroscopic Characterisation, and Method for Analysis of Anomeric and Boron Equilibria

Molecules
This paper describes the first detailed NMR analysis of the borylated intermediates and target compounds for a small library of pyrrolidine iminosugars of l-gulose absolute stereochemical configuration.
Michela Simone
doaj   +1 more source

Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores

Beilstein Journal of Organic Chemistry, 2015
The synthesis and photophysical properties of the first examples of iminosugar clusters based on a BODIPY or a pyrene core are reported. The tri- and tetravalent systems designed as molecular probes and synthesized by way of Cu(I)-catalysed azide–alkyne ...
Mathieu L. Lepage, Antoine Mirloup, Manon Ripoll, Fabien Stauffert, Anne Bodlenner, Raymond Ziessel, Philippe Compain   +6 more
doaj   +1 more source

Stereoselective Synthesis of Glycomimetic Amines From Biomass‐Derived Cyrene

European Journal of Organic Chemistry, Volume 29, Issue 18, 14 May 2026.
2,3,4‐Trideoxy‐2‐mannosamines, including the unsubstituted one, are accessible as the only endo diastereoisomers by reductive amination of the green solvent Cyrene, derived from pyrolysis of cellulose containing waste biomass. The products are useful chiral synthetic intermediate to nitrogenated glycomimetics.
Debora Pratesi, Marta Rigacci, Francesca Cardona, Camilla Matassini, Andrea Goti   +4 more
wiley   +1 more source

Chain-Branched Polyhydroxylated Octahydro-1H-Indoles as Potential Leads against Lysosomal Storage Diseases

Pharmaceuticals, 2019
Here, the synthesis and glycosidase inhibition properties of the two first known 3-ethyloctahydro-1H-indole-4,5,6-triols are reported. This study shows the transformation of d-glucose into polyhydroxylated 1-(2-nitrocyclohexane) acetaldehydes, followed ...
Juan C. Estévez, Marcos A. González, M. Carmen Villaverde, Yuki Hirokami, Atsushi Kato, Fredy Sussman, David Reza, Ramón J. Estévez   +7 more
doaj   +1 more source

Rapid Microwave‐Assisted Iodination of Glycals to 2‐Iodoglycals Under Operationally Simple Conditions: Next Chapter in (C‐2)‐Functionalisation of Sugar Moieties

Chemistry–Methods, Volume 6, Issue 5, May 2026.
Microwave‐assisted protocol is presented as an alternative method for synthesis of 2‐iodoglycals. These conditions are characterised with the simple reaction setup giving an access to 16 examples of iodinated sugar derivatives including trisaccharide residue or antidiabetic acarbose scaffold.
Dariusz Baran, Agnieszka Ewa Kuklewska, Morgane de Robichon, Bartłomiej Stankiewicz, Karolina Hurej, Aneta Pobudkowska, Andrzej Plichta, Angélique Ferry, Maciej Malinowski   +8 more
wiley   +1 more source

Borylated 5-Membered Ring Iminosugars: Synthesis and Biological Evaluation for Glycosidase Inhibition and Anticancer Properties for Application in Boron Neutron Capture Therapy (BNCT)—Part 2

Pharmaceuticals
Background: The synthesis and biological investigation of pyrrolidine (L-gulo) iminosugars bearing an organic boron pharmacophore in ortho and meta positions of an N-benzyl group is reported.
Kate Prichard, Kosuke Yoshimura, Suzuka Yamamoto, Atsumi Taguchi, Barbara Bartholomew, Jayne Gilbert, Jennette Sakoff, Robert Nash, Atsushi Kato, Michela Simone   +9 more
doaj   +1 more source