Results 71 to 80 of about 1,302 (169)

Synthesis of Substituted Cyclic Amines From Protected Amino Acids Using Oxidative Decarboxylation and Alkylation

Asian Journal of Organic Chemistry, Volume 15, Issue 2, February 2026.
Simple access to alkylated 3D scaffold via oxidative radical decarboxylation, trapping of iminium, and successive reaction with organometallic reagent in the presence of BF3 . ABSTRACT Cyclic amines are vital scaffolds in bioactive molecules and drug discovery, often functionalized via electrochemical Shono‐type oxidation to access N‐acyliminium ...
Dario Corbisiero, Arthur F. Rossignol, Francesco Calogero, Andrea Gualandi, Emanuele Pinosa, Luca Sensoli, Paolo Ronchi, Pier Giorgio Cozzi   +7 more
wiley   +1 more source

Direct and highly stereoselective synthesis of quinolizidine iminosugars promoted by L-proline-Et3N

, 2019
A mild and effective method for the synthesis of polyhydroxylated quinolizidine iminosugars is described. The Mannich-type reaction of iminosugar C-glycosides with aldehyde in the presence of L-proline-Et3N provides polyhydroxylated quinolizidine ...
Zhang, Jichao, Yuan, Wen, Pan, Yang, Zhang, Xiaoke, Liang, Peng, Shao, Huawu, Jiao, Wei   +6 more
core   +1 more source

N-2 Alkylated analogues of aza-galactofagomine as potential inhibitors of β-glucosidase [PDF]

Journal of the Serbian Chemical Society
The synthesis of four N-2-alkylated aza-galactofagomine (AGF) analogues was achieved by intermolecular reductive hydrazination or alkylation of suitably protected AGF. The synthesized compounds were evaluated as potential β-glucosidase inhibitors.
Đurković Filip, Zlatović Mario, Sladić Dušan, Novaković Irena, Bihelović Filip, Ferjančić Zorana   +5 more
doaj   +1 more source

N-Nonyloxypentyl-l-Deoxynojirimycin Inhibits Growth, Biofilm Formation and Virulence Factors Expression of Staphylococcus aureus

Antibiotics, 2020
Staphylococcus aureus is one of the major causes of hospital- and community-associated bacterial infections throughout the world, which are difficult to treat due to the rising number of drug-resistant strains.
Eliana De Gregorio, Anna Esposito, Adriana Vollaro, Maria De Fenza, Daniele D’Alonzo, Antonella Migliaccio, Vita Dora Iula, Raffaele Zarrilli, Annalisa Guaragna   +8 more
doaj   +1 more source

Development of Peptide Glucosyltransferase Inhibitors With Comprehensive Coverage Across Clostridioides difficile Toxin B Sub‐Types

Biotechnology and Bioengineering, Volume 123, Issue 2, Page 310-323, February 2026.
ABSTRACT Clostridioides difficile infection presents an escalating clinical challenge due to the proliferation of hypervirulent and antibiotic‐resistant strains. The primary symptoms of disease, namely colitis and diarrhea, are induced by the release of two toxins: TcdA and TcdB.
Carly M. Catella, Sudeep Sarma, Caroline M. Hinesley, Corey E. Febo, Keith A. Breau, Deniz Durmusoglu, Ethan Purnell, Scott T. Magness, Carol K. Hall, Stefano Menegatti, Nathan Crook   +10 more
wiley   +1 more source

Synthesis of lipophilic 1-deoxygalactonojirimycin derivatives as D-galactosidase inhibitors

Beilstein Journal of Organic Chemistry, 2010
N-Alkylation at the ring nitrogen of the D-galactosidase inhibitor 1-deoxygalactonojirimycin with a functionalised C6 alkyl chain followed by modification with different aromatic substituents provided lipophilic 1-deoxygalactonojirimycin derivatives ...
Georg Schitter, Elisabeth Scheucher, Andreas J. Steiner, Arnold E. Stütz, Martin Thonhofer, Chris A. Tarling, Stephen G. Withers, Jacqueline Wicki, Katrin Fantur, Eduard Paschke, Don J. Mahuran, Brigitte A. Rigat, Michael Tropak, Tanja M. Wrodnigg   +13 more
doaj   +1 more source

Simultaneous Grafting of 3,4,5‐Trihydroxypiperidine Iminosugars Onto Multivalent Scaffolds via Double Reductive Amination Provides New GCase Inhibitors

Chemistry – A European Journal, Volume 32, Issue 2, 9 January 2026.
A small set of low‐valency multivalent 3,4,5‐trihydroxypiperidines was prepared through double reductive amination (DRA) of a sugar‐derived dialdehyde. Among them, trivalent derivative 37 emerged as a potent β‐glucocerebrosidase (GCase) inhibitor displaying an unexpected mixed‐type kinetic profile. The integration of kinetic analysis, NMR, docking, and
Maria Giulia Davighi, Francesca Clemente, Alessio Morano, Francesca Mangiavacchi, Francesca Cardona, Andrea Goti, Paolo Paoli, Amelia Morrone, Ferran Nieto‐Fabregat, Roberta Marchetti, Camilla Matassini   +10 more
wiley   +1 more source

Iminosugars and methods of treating Bunyaviral and Togaviral diseases [PDF]

, 2016
The present application relates to iminosugars and methods of treating viral infections with iminosugars and, in particular, to the use of iminosugars for treatment and/or prevention of viral infections caused by or associated with a virus belonging to ...

core  

Methodology development for the synthesis of iminosugars [PDF]

, 2021
<p>This thesis investigated the development and application of methodology for the synthesis of iminosugars. The first portion of this thesis (Chapters 2 and 3) explored the scope of previously established protecting-group-free Vasella-reductive-amination and I2-mediated carbamate annulation methodology initially developed within the Stocker ...
openaire   +1 more source

Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies

Journal of Enzyme Inhibition and Medicinal Chemistry
We developed new iminosugar-based glycosidase inhibitors against SARS-CoV-2. Known drugs (miglustat, migalastat, miglitol, and swainsonine) were chosen as lead compounds to develop three classes of glycosidase inhibitors (α-glucosidase, α-galactosidase ...
Zorana Ferjancic, Filip Bihelovic, Bojan Vulovic, Radomir Matovic, Milena Trmcic, Aleksandar Jankovic, Milos Pavlovic, Filip Djurkovic, Radivoje Prodanovic, Aleksandra Djurdjevic Djelmas, Nevena Kalicanin, Mario Zlatovic, Dusan Sladic, Thomas Vallet, Marco Vignuzzi, Radomir N. Saicic   +15 more
doaj   +1 more source