Results 61 to 70 of about 1,302 (169)

Red Grape Pomace as a Valuable Source of Biomolecules With Inhibitory Effect on Pro‐Inflammatory and Metabolic Syndrome‐Associated Enzymes: Eco‐Friendly Extraction and Mechanism of Inhibition

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Superposition of the top scoring enzyme‐ligand models resulting from the in silico docking tests: complexes formed by α‐amylase (a), α‐glucosidase (b), and lipoxygenase (c) with vanillic acid (magenta), azelaic acid (red), phlorizin (yellow), cis‐polydatin (green), chlorogenic acid (orange), suberic acid (black), abietic acid (blue), t‐resveratrol ...
Nicoleta Balan, Silviu Măntăilă, Ilir Mërtiri, Elisabeta Irina Geana, Iuliana Aprodu, Gabriela Râpeanu, Nicoleta Stănciuc   +6 more
wiley   +1 more source

Borylated Five-Membered Ring Iminosugars: Synthesis, Spectroscopic Analysis, and Biological Evaluation for Glycosidase Inhibition and Anticancer Properties for Application in Boron Neutron Capture Therapy (BNCT)—Part 1

Pharmaceuticals
Background/Objectives: This article reports pyrrolidine iminosugars of L-gulose absolute stereochemical configuration that are functionalised via N-alkylation to bear boronate ester and boronic acid pharmacophores.
Kate Prichard, Suzuka Yamamoto, Yuna Shimadate, Kosuke Yoshimura, Barbara Bartholomew, Jayne Gilbert, Jennette Sakoff, Robert Nash, Atsushi Kato, Michela Simone   +9 more
doaj   +1 more source

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff, Jemma Arakelyan, Billy Wai‐Lung Ng   +2 more
wiley   +1 more source

Developments in Carbohydrate-Based Metzincin Inhibitors

Pharmaceuticals, 2020
Matrix metalloproteinases (MMPs) and A disintegrin and Metalloproteinase (ADAMs) are zinc-dependent endopeptidases belonging to the metzincin superfamily.
Doretta Cuffaro, Elisa Nuti, Felicia D’Andrea, Armando Rossello   +3 more
doaj   +1 more source

An Australian standard of care for Niemann–Pick disease type C

Internal Medicine Journal, Volume 56, Issue 5, Page 832-848, May 2026.
Abstract Background Niemann–Pick disease type C (NP‐C) is the fifth most prevalent lysosomal disorder in Australia. Diagnostic delay is common, impacted by disease heterogeneity, limited awareness within clinical gateway services and exclusion from state‐based newborn screening programmes.
Michel Tchan, Nicholas Smith, Heidi Peters, Ellie Van Velsen, Catherine Marraffa, Carolyn Ellaway, Katrina Cruz, Shekeeb S. Mohammad, Maina Kava, Joy Yaplito‐Lee, Shanti Balasubramaniam, Yusof Rahman, Brendon Boot, Ashley Bush, Felicity Munro, Leniza Hamoy, Ya Hui Hung, Philippa Johnston, Deanna Carpino, Molly Williams, Sharmila Kiss, Rebecca Quin, Ingrid Sutherland, Mark Walterfang   +23 more
wiley   +1 more source

Total Synthesis of ( + )-Swainsonine, (–)- Swainsonine, ( + )-8--

Natural Product Communications, 2022
A tactical combination of either ( S )- or ( R )-proline catalyzed aldol reaction followed by intramolecular reductive amination enabled the synthesis of a chiral pyrrolidine derivative with 3 contiguous stereocenters in only 2 synthetic steps, starting ...
Milos Trajkovic, Milos Pavlovic, Filip Bihelovic, Zorana Ferjancic, Radomir N Saicic   +4 more
doaj   +1 more source

The Race to Salvage Glucocerebrosidase: Understanding Small‐Molecule Therapies for GBA1‐Associated Parkinsonism

Movement Disorders, Volume 41, Issue 3, Page 596-602, March 2026.
Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson, Tiffany C. Chen, Logan M. Glasstetter, Yu Chen, Juan J. Marugan, Ellen Sidransky   +5 more
wiley   +1 more source

Synthesis of “All-Cis” Trihydroxypiperidines from a Carbohydrate-Derived Ketone: Hints for the Design of New β-Gal and GCase Inhibitors

Molecules, 2020
Pharmacological chaperones (PCs) are small compounds able to rescue the activity of mutated lysosomal enzymes when used at subinhibitory concentrations.
Maria Giulia Davighi, Francesca Clemente, Camilla Matassini, Amelia Morrone, Andrea Goti, Macarena Martínez-Bailén, Francesca Cardona   +6 more
doaj   +1 more source

The transformative power of structural predictions with AI in plant science

The Plant Journal, Volume 125, Issue 6, March 2026.
SUMMARY Since the introduction of various structural prediction programs, the emerging transformative power of these technologies in plant science is apparent. Not only programs like AlphaFold but also RoseTTAFold, Chai‐1 and Boltz suddenly enable plant scientists to predict structures with high confidence. This ability has facilitated the discovery of
Joy Chenqu Lyu, Renier A. L. Van der Hoorn   +1 more
wiley   +1 more source

-Diethylphosphonomethyl and -difluoromethyl Iminosugars from Sugar Lactams

, 2022
International audienceA strategy allowing the straightforward synthesis of 1-C-phosphonomethyl and 1-C-phosphonodifluoromethyl iminosugars is reported.
Désiré, Jérôme, Jérôme Désiré, Auberger, Nicolas, Blériot, Yves, Tran, Thanh Van, Thanh Van Tran, Nicolas Auberger, Yves Blériot   +7 more
core   +1 more source