Results 81 to 90 of about 1,302 (169)

Evaluation of nonnatural L-iminosugar C,C-glycosides, a new class of C-branched iminosugars, as glycosidase inhibitors

, 2023
International audienceCapitalizing on a previously developed Staudinger/azaWittig/Grignard (SAWG)-ring contraction sequence that furnished protected six-membered L-iminosugar C,C-glycosides bearing an allyl group and various substituents at the ...
Désiré, Jérôme, Debbah, Zakaria, Atsushi Kato, Jérôme Désiré, Marrot, Jérôme, Zakaria Debbah, Blériot, Yves, Jérôme Marrot, Gueyrard, David, Kato, Atsushi, David Gueyrard, Yves Blériot   +11 more
core   +1 more source

The First l-Iduronic Acid-Type 1-N-Iminosugars Having Inhibitory Activity of Experimental Metastasis

, 2016
The First l-Iduronic Acid-Type 1-N-Iminosugars Having Inhibitory Activity of Experimental ...
Hayamitsu Adachi (1666837), Takahiko Satoh (2995797), Shinichi Kondo (2995791), Masayuki Azetaka (2995800), Yoshio Nishimura (1965370), Harumi Fukuyasu (2995785), Yumiko Iizuka (2995794), Tomio Takeuchi (2995788)   +7 more
core   +2 more sources

N-nonyloxypentyl-L-deoxynojirimycin reduces Stenotrophomonas maltophilia virulence in vitro and in Galleria mellonella infection model

Frontiers in Microbiology
IntroductionStenotrophomonas maltophilia is an opportunistic pathogen able to resist multiple classes of antibiotics and form robust biofilms, making it difficult to treat.MethodsThe antimicrobial and anti-virulence activity of the iminosugar N ...
Maria Stabile, Maria Stabile, Anna Esposito, Antonella Migliaccio, Antonella Migliaccio, Leandra Sepe, Rosaria Artiano, Antonella Ricca, Vita Dora Iula, Raffaele Zarrilli, Annalisa Guaragna, Eliana De Gregorio   +11 more
doaj   +1 more source

A Madagascar Sponge Batzella sp. as a Source of Alkylated Iminosugars

, 2016
Three new C-alkylated iminosugars, batzellasides A (3), B (4), and C (5), along with the known halitoxin (2) polymer were isolated from a Batzella sp. sponge, collected off the west coast of Madagascar. Although this class of azasugars is well known from
Nathaniel L. Segraves (2309521), Phillip Crews (594754)   +1 more
core   +1 more source

Probing the Influence of Linker Length and Flexibility in the Design and Synthesis of New Trehalase Inhibitors

Molecules, 2018
This work aims to synthesize new trehalase inhibitors selective towards the insect trehalase versus the porcine trehalase, in view of their application as potentially non-toxic insecticides and fungicides.
Giampiero D’Adamio, Matilde Forcella, Paola Fusi, Paolo Parenti, Camilla Matassini, Xhenti Ferhati, Costanza Vanni, Francesca Cardona   +7 more
doaj   +1 more source

Stereoselectively fluorinated N-heterocycles: a brief survey

Beilstein Journal of Organic Chemistry, 2013
The stereoselective incorporation of fluorine atoms into N-heterocycles can lead to dramatic changes in the molecules’ physical and chemical properties.
Xiang-Guo Hu, Luke Hunter
doaj   +1 more source

Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors

Beilstein Journal of Organic Chemistry, 2012
A small set of nojirimycin- and pyrrolidine-based iminosugar derivatives has been synthesized and evaluated as potential inhibitors of porcine and insect trehalases.
Davide Bini, Francesca Cardona, Matilde Forcella, Camilla Parmeggiani, Paolo Parenti, Francesco Nicotra, Laura Cipolla   +6 more
doaj   +1 more source

Synthetic N-Alkylated Iminosugars as New Potential Immunosuppressive Agents

, 2016
The new emerging immunosuppressive effects displayed by iminosugars have not been much investigated so far. Several new N-alkyl dideoxy iminoalditols were designed and synthesized to explore their immunosuppressive effects.
Jia Ye (6541), Xin-Shan Ye (1393843), Guan-Nan Wang (323894), Yulan Xiong (250746), Li-He Zhang (114202)   +4 more
core   +1 more source

Synthesis of fused tetrazolo iminosugars from azido monosaccharide derivatives [PDF]

, 2014
Synthesis of fused tetrazolo iminosugars from azido monosaccharide derivativesUniversidad de Málaga.
Pino-González, María Soledad
core  

The synthesis of azetidine and piperidine iminosugars from monosaccharides [PDF]

, 2016
Iminosugars are polyhydroxylated alkaloids, and can be generally defined as sugar mimetics in which the endocyclic oxygen atom has been replaced with a basic nitrogen.

core   +1 more source