Results 101 to 110 of about 1,302 (169)

Stereocontrolled synthesis of polyhydroxylated bicyclic azetidines as a new class of iminosugars

, 2018
First examples of a new class of constrained bicyclic iminosugars have been synthesized by a non-classical Dieckmann-like reaction.
Nicolas Kern, Damien Tardieu, Raphaël Hensienne, Philippe Compain, Damien Hazelard, Maciej Malinowski, Anne Bodlenner   +6 more
core   +1 more source

Total asymmetric syntheses of iminosugars

, 2015
This thesis is concerned with the development of ring-closing iodoamination and ringexpansion methodology and its subsequent application to the asymmetric syntheses of pyrrolidine and piperidine iminosugars. Chapter 1 highlights the remarkable biological properties displayed by iminosugars and introduces methods for the formation of the pyrrolidine and
Figuccia, A, Figuccia, Aude
openaire   +1 more source

N-Alkylated L-Iminosugars as novel anti-inflammatory and anti-biofilm tools for Cystic Fibrosis Lung Infections

, 2019
In search for novel drug targets aimed to control CF lung infections, a key role of the non-lysosomal glucosidase 2 (GBA2-encoded GNLase) in proinflammatory state characterizing CF cells has been highlighted.
Munari, S., De Checchi, M. C., De Fenza Maria, Lippi, G., Santangelo, A., Baragonzi, A., D’Alonzo Daniele, De Fino, I., Loberto, N., Aureli, M., Romanucci, S., De Gregorio Eliana, Rocco L., Rossi, A., Guaragna, A, Esposito Anna, Tamanini, A.   +16 more
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Synthesis of N-alkyl substituted iminosugars from D-ribose

, 2017
An effective and facile method for the synthesis of N-alkylated hydroxylpyrrolidine and hydroxylpiperidine is described. A number of N-alkyl substituted iminosugars were prepared using iodine-induced intramolecular cyclization of acyclic alkenylamines as
Wei Zou, Pan, Yang, Huawu Shao, Zou, Wei, Wang, Haibo, Yang Pan, Shao, Huawu, Qin Tang, Tang, Qin, Haibo Wang   +9 more
core   +1 more source

Synthesis and biological properties of multivalent iminosugars

, 2015
International audienceGlycosidases are extremely widespread enzymes responsible for the cleavage of glycosidic bonds in glycoconjugates found in living organisms.
Marra, Alberto, Dumy, Pascal, Longevial, Jean-François, Zelli, Renaud   +3 more
core   +1 more source

A Rapid Synthesis of Hexofuranose-like Iminosugars Using Ring-Closing Metathesis

, 2016
Two new 1-N-iminosugars have been prepared as hexofuranose analogues in an efficient manner by an RCM-based route. Both 3,4-disubstituted pyrrolidines display moderate inhibitory activity against Mycobacterium smegmatis galactan ...
Neil R. Thomas (1937950), Claire Wilson (1362369), Sylvaine Cren (2379862)   +2 more
core   +1 more source

Stereocontrolled synthesis of pyrrolidine iminosugars through asymmetric dihydroxylation of optically active olefins

, 2018
Iminosugars, carbohydrate analogues in which the endocyclic oxygen is replaced by a nitrogen atom, are nowadays the most attractive class of sugar mimics because of their high glycosidase and glycosyltransferase inhibitor activity and hence their ...
Righi Giuliana, De Angelis Martina, Forte Giorgia, LUCARINI, CLAUDIA, AGOSTINELLI, SONIA, Sappino Carla   +5 more
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An Efficient and Simple Method for Stereoselective Synthesis of N-Substituted Iminosugars from D-Xylose Derivative

, 2014
A series of new N-substituted iminosugars were successfully synthesized through a general synthetic route from D-xylose derivative. This approach provided a convenient access to the synthesis of N-alkylated iminosugars as potential glucosidase inhibitors,
Zhang, Jichao, Yuan, Wen, Ma, Xiaofeng, Wang, Haibo, Shao, HW (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Res Ctr, Chengdu 610041, Sichuan, Peoples R China., Shao, Huawu   +5 more
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Stereocontrolled synthesis of pyrrolidine iminosugars through asymmetric dihydroxylation reaction

, 2019
Iminosugars are carbohydrate analogues in which the endocyclic oxygen is replaced by a nitrogen atom [1]. These compounds are nowadays the most attractive class of sugar mimics because of their high glycosidase and glycosyltransferase inhibitor activity ...
Forte, Giorgia, Sappino, Carla, Martina, De Angelis, Lucarini, Claudia, Agostinelli, Sonia, Giuliana, Righi   +5 more
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The synthesis of azetidine and piperidine iminosugars from monosaccharides

, 2012
Iminosugars are polyhydroxylated alkaloids, and can be generally defined as sugar mimetics in which the endocyclic oxygen atom has been replaced with a basic nitrogen.
Fleet, George W J, Lenagh-Snow, Gabriel Matthew Jack   +1 more
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