Results 121 to 130 of about 1,302 (169)
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Iminosugar-Producing Thai Medicinal Plants
Journal of Natural Products, 2005Alpha-1-C-hydroxymethylfagomine (7), 3-O-beta-D-glucopyranosyl-DMDP (12), and 2,5-dideoxy-2,5-imino-D-glucitol (13) were isolated from the Thai traditional crude drug "Non tai yak" (Stemona tuberosa), which also contains a high concentration level of alpha-homonojirimycin (0.1% dry weight).
Naoki, Asano +10 more
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Synthetic Access to the First Spirocyclopropyl Iminosugar
Synlett, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Christophe Laroche +4 more
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The Journal of Organic Chemistry, 2018
A simple and efficient method for the stereoselective synthesis of isoxazoline/isoxazole-fused iminosugar derivatives has been developed using intramolecular nitrile oxide cycloaddition (INOC) as a key step. Iminosugar C-nitromethyl glycosides, derived from simple carbohydrates, served as excellent nitrile oxide precursors in 1,3-dipolar cycloaddition ...
Sure Siva Prasad, Sundarababu Baskaran
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A simple and efficient method for the stereoselective synthesis of isoxazoline/isoxazole-fused iminosugar derivatives has been developed using intramolecular nitrile oxide cycloaddition (INOC) as a key step. Iminosugar C-nitromethyl glycosides, derived from simple carbohydrates, served as excellent nitrile oxide precursors in 1,3-dipolar cycloaddition ...
Sure Siva Prasad, Sundarababu Baskaran
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Synthetic Methods for the Preparation of Iminosugars
1998Barbara La Ferla, Francesco Nicotra
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Iminosugars as a new class of cholinesterase inhibitors
Bioorganic & Medicinal Chemistry Letters, 2015To further extend the scope of iminosugar biological activity, a systematic structure-activity relationship investigation has been performed by synthesizing and evaluating as cholinesterase inhibitors a library of twenty-three iminoalditols with different substitutions and stereochemistry patterns.
Decroocq, Camille +7 more
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Synthesis of multivalent iminosugars
2012comunicazione ...
CARDONA, FRANCESCA +3 more
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Iminosugars past, present and future: medicines for tomorrow
Drug Discovery Today, 2011Iminosugars comprise the most attractive class of carbohydrate mimetics reported to date and are ideally positioned to take advantage of our increasing understanding of glycobiology in the search for new medicines. First-generation iminosugar drugs suffered from lack of adequate selectivity, resulting in considerable side-effects in the clinic. Current
Graeme, Horne +4 more
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General strategies for the synthesis of iminosugars and new approaches towards iminosugar libraries
2007This chapter will provide an up-to-date review of synthetic methods for the preparation of iminosugars and related compounds. Iminosugars are still the object of intense synthetic investigations, both for the improvement of the synthetic methods and for the preparation of novel structures. Strategies from both sugars and non-carbohydrate precursors can
LA FERLA, BARBARA +2 more
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Current Topics in Medicinal Chemistry, 2003
Cancer metastasis is one of the major challenges in cancer research. Inhibitors of tumor metastasis are rapidly emerging as important new drug candidates for cancer therapy. Tumor metastasis formation occurs via a complex multistage process which involves a crucial step of tumor invasion through the basement membrane.
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Cancer metastasis is one of the major challenges in cancer research. Inhibitors of tumor metastasis are rapidly emerging as important new drug candidates for cancer therapy. Tumor metastasis formation occurs via a complex multistage process which involves a crucial step of tumor invasion through the basement membrane.
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