Results 111 to 120 of about 1,302 (169)
Synthesis and Therapeutic Applications of Iminosugars in Cystic Fibrosis. [PDF]
International Journal of Molecular Sciences, 2020 Iminosugars are sugar analogues endowed with a high pharmacological potential. The wide range of biological activities exhibited by these glycomimetics associated with their excellent drug profile make them attractive therapeutic candidates for several ...
Maria Cristina Dechecchi +2 more
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Iminosugars as glycosyltransferase inhibitors
Organic & Biomolecular Chemistry, 2021The review describes the syntheses and inhibition properties of pyrrolidine, piperidine, azepane, pyrrolizidine and indolizidine iminosugars, as well as iminosugar nucleotides and iminodi- and -oligosaccharides.
Irene Conforti, Alberto Marra
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Tetrahedron, 2021 A stereodivergent approach for producing piperidine iminosugars has been developed employing a common optically active precursor. The key steps of the synthetic pathway are the double diastereoselection in the asymmetric dihydroxylation of the suitable ...
Martina De Angelis +2 more
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Mechanisms of Antiviral Activity of Iminosugars Against Dengue Virus [PDF]
Advances in Experimental Medicine and Biology, 2018 The antiviral mechanism of action of iminosugars against many enveloped viruses, including dengue virus (DENV), HIV, influenza and hepatitis C virus, is believed to be mediated by inducing misfolding of viral N-linked glycoproteins through inhibition of ...
Joanna L Miller +2 more
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Bioorganic & Medicinal Chemistry, 2013
Imino- and azasugar glycosidase inhibitors display pH dependant inhibition reflecting that both the inhibitor and the enzyme active site have groups that change protonation state with pH. With the enzyme having two acidic groups and the inhibitor one basic group, enzyme-inhibitor complexes with three (EH3I), two (EH2I), one (EHI), or no protons (EI ...
López, Óscar +3 more
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Imino- and azasugar glycosidase inhibitors display pH dependant inhibition reflecting that both the inhibitor and the enzyme active site have groups that change protonation state with pH. With the enzyme having two acidic groups and the inhibitor one basic group, enzyme-inhibitor complexes with three (EH3I), two (EH2I), one (EHI), or no protons (EI ...
López, Óscar +3 more
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Iminosugar C-Nitromethyl Glycosides and Divergent Synthesis of Bicyclic Iminosugars
Organic Letters, 2017An efficient one-pot method for the stereoselective synthesis of novel iminosugar C-nitromethyl glycosides is described. This new class of iminosugar glycosides has versatile nitromethyl functionality whose utility was further demonstrated in the single-step synthesis of bicyclic iminosugars.
Sure Siva Prasad +3 more
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General Methods for Iminosugar Synthesis
Current Topics in Medicinal Chemistry, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
CIPOLLA, LAURA FRANCESCA +2 more
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Iminosugar thioglycosides as glycosyl donors: a route to disaccharides with an iminosugar moiety
Tetrahedron Letters, 2008The iminosugar thioglycosides are used as glycosyl donors in glycosidation reactions. Thereby, iminosugar glycosides and disaccharide analogues with an iminosugar moiety are prepared. The yields are high and the method is stereoselective.
José Fuentes +3 more
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A Concise Enantioselective Synthesis of Iminosugar Derivatives.
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Wei-Wei, Liao +2 more
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An Expeditious Synthesis of Iminosugars
Australian Journal of Chemistry, 2010A short and expedient synthesis of the potent glycosidase inhibitors, 1-deoxynojirimycin, miglitol, miglustat, 1-deoxymannojirimycin, and 1-deoxygalactonojirimycin is presented.
Michael N. Gandy +2 more
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