Results 91 to 100 of about 1,302 (169)
Diversity-oriented synthesis and study of triazole-fused bicyclic iminosugars
A Cu-free synthesis of triazole-fuzed iminosugars was achieved using intramolecular azide–alkyne cycloaddition (IAAC) as the key step. The iminosugars were subjected to docking, glycosidase inhibition, cytotoxicity and conformational studies.
Pramodh Rao N +2 more
core +1 more source
, 2020 International audienceRadical thiol-ene coupling was exploited for the first time to prepare imino-disaccharides and multivalent iminosugars starting from sugar thiols and iminosugar alkenes or iminosugar thiols and tetra-allylated calixarene ...
Marra, Alberto +2 more
core +1 more source
Molecules, 2013 D-Glucopyranose-derived and L-idopyranose-derived piperidine nitrones were synthesized in good overall yields through six-step reaction sequence starting from readily available 2,3,4,6-tetra-O-benzyl-D-glucopyranose.
Chu-Yi Yu +4 more
doaj +1 more source
Highly Selective Synthesis of 1-N-Iminosugars of the d-Glucose and -Glucuronic Acid Types
, 2016 Highly Selective Synthesis of 1-N-Iminosugars of the d-Glucose and -Glucuronic Acid ...
Yong Jip Kim (3007068) +2 more
core +1 more source
Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores
Beilstein Journal of Organic Chemistry, 2014 Cyclic N-propargyl α-peptoids of various sizes were prepared by way of macrocyclizations of linear N-substituted oligoglycines. These compounds were used as molecular platforms to synthesize a series of iminosugar clusters with different valency and ...
Mathieu L. Lepage +6 more
doaj +1 more source
Targeting N-Acetylglucosaminidase in Staphylococcus aureus with Iminosugar Inhibitors
AntibioticsBacteria are capable of remarkable adaptations to their environment, including undesirable bacterial resistance to antibacterial agents. One of the most serious cases is an infection caused by multidrug-resistant Staphylococcus aureus, which has ...
Janja Sluga +9 more
doaj +1 more source
Iminosugars and methods of treating viral diseases: World Intellectual Property Ogranization patent WO/2010/096764 [PDF]
, 2016 Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using ...
core
Preparation of water-soluble glycopolymers derived from five-membered iminosugars
, 2019 Iminosugars are carbohydrate mimetics that constitute the main group of oligosaccharide processing enzyme inhibitors. They play an important role in cell-cell recognition processes, thereby presenting a wide range of potential therapeutic applications.
Galbis Fuster, Elsa +4 more
core +1 more source
MoleculesMorquio A syndrome is a lysosomal disorder caused by the deficiency of the lysosomal enzyme N-acetylgalactosamine 6-sulfatase (GALNS, EC 3.1.6.4).
Maria Giulia Davighi +8 more
doaj +1 more source
Spiro Iminosugars: Structural Diversity and Synthetic Strategies
, 2019 International audienceFrom their discovery in the late 1960s, iminosugars have undergone an expansion from an area of science limited to a few researchers to a field that now attracts the interest of members of the whole synthetic organic chemistry ...
Compain, Philippe +7 more
core +1 more source