Results 1 to 10 of about 12,901 (257)

Rapid-Response and Highly Sensitive Boronate Derivative-Based Fluorescence Probe for Detecting H2O2 in Living Cells

Journal of Analytical Methods in Chemistry, 2019
Intracellular H2O2 monitoring is important and has driven researchers to pursue advancements for the rapid identification of H2O2, since H2O2 is short-lived in cell lines.
Muthusamy Selvaraj, Kanagaraj Rajalakshmi, Yun-Sik Nam, Yeonhee Lee, Byoung Chan Kim, Sung Jin Pai, Sang Soo Han, Kang-Bong Lee   +7 more
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Diastereoselective Synthesis of the Borylated d-Galactose Monosaccharide 3-Boronic-3-Deoxy-d-Galactose and Biological Evaluation in Glycosidase Inhibition and in Cancer for Boron Neutron Capture Therapy (BNCT)

Molecules, 2023
Drug leads with a high Fsp3 index are more likely to possess desirable properties for progression in the drug development pipeline. This paper describes the development of an efficient two-step protocol to completely diastereoselectively access a ...
Michela I. Simone
doaj   +1 more source

Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

Molecules, 2022
In this study, privileged boronic acid ester was introduced into the right wing of etravirine (ETR) to obtain a series of novel boronate-containing derivatives.
Da Feng, Hao Lin, Liyang Jiang, Zhao Wang, Yanying Sun, Zhongxia Zhou, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu   +10 more
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A simple generic method for analyzing water sensitive pinacol boronate compounds by hydrophilic interaction liquid chromatography

Journal of Chromatography Open, 2022
Pinacol boronates are widely used in the pharmaceutical and biomedical industries as primary building blocks for many chemical reactions, such as Suzuki coupling.
Lulu Dai, Joseph Gonzalez, Kelly Zhang
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Thiol Peroxidases as Major Regulators of Intracellular Levels of Peroxynitrite in Live Saccharomyces cerevisiae Cells

Antioxidants, 2020
Thiol peroxidases (TP) are ubiquitous and abundant antioxidant proteins of the peroxiredoxin and glutathione peroxidase families that can catalytically and rapidly reduce biologically relevant peroxides, such as hydrogen peroxide and peroxynitrite ...
André Luís Condeles, Fernando Gomes, Marcos Antonio de Oliveira, Luís Eduardo Soares Netto, José Carlos Toledo Junior   +4 more
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Glucose-Responsive Gene Delivery at Physiological pH through Tertiary-Amine Stabilized Boronate-PVA Particles Synthesized by One-Pot Reaction

Pharmaceutics, 2021
We report a physiologically stable and cytocompatible glucose-responsive nonviral gene delivery system made up of boronate functionalized polymeric material.
Mangesh Morey, Akshay Srivastava, Abhay Pandit   +2 more
doaj   +1 more source

Ultrasensitive dynamic light scattering immunosensing platform for NT-proBNP detection using boronate affinity amplification

Journal of Nanobiotechnology, 2022
Highlight 1. We developed a new DLS immunosensing technology for the rapid and sensitive detection of glycoprotein NT-proBNP. 2. The boronate affinity recognition amplified nanoparticle aggregation was designed to enable highly sensitive DLS transduction.
Jiaqi Hu, Lu Ding, Jing Chen, Jinhua Fu, Kang Zhu, Qian Guo, Xiaolin Huang, Yonghua Xiong   +7 more
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Synthesis of Novel Multifunctional bora-Ibuprofen Derivatives

Inorganics, 2023
A unique class of β-boron-functionalized non-steroidal anti-inflammatory compound (pinB-NSAID) was previously synthesized via copper-catalyzed 1,2-difunctionalization of the respective vinyl arene with CO2 and B2pin2 reagents.
Randika T. Abeysinghe, Alexis C. Ravenscroft, Steven W. Knowlden, Novruz G. Akhmedov, Brian S. Dolinar, Brian V. Popp   +5 more
doaj   +1 more source

Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology

Frontiers in Chemistry, 2020
Boronate-based molecular probes are emerging as one of the most effective tools for detection and quantitation of peroxynitrite and hydroperoxides.
Adam Sikora, Jacek Zielonka, Karolina Dębowska, Radosław Michalski, Renata Smulik-Izydorczyk, Jakub Pięta, Radosław Podsiadły, Angelika Artelska, Karolina Pierzchała, Balaraman Kalyanaraman   +9 more
doaj   +1 more source

Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3

PLoS ONE, 2021
Antimicrobial resistance (AMR) mediated by β-lactamases is the major and leading cause of resistance to penicillins and cephalosporins among Gram-negative bacteria.
Vijay Kumar, Samantha L. Viviani, Jeeda Ismail, Shreya Agarwal, Robert A. Bonomo, Focco van den Akker   +5 more
doaj   +3 more sources