Results 11 to 20 of about 12,901 (257)
Stereogenic boron in 2-amino-1,1-diphenylethanol-based boronate–imine and amine complexes
Beilstein Journal of Organic Chemistry, 2011 Racemic boronate–imine and boronate–amine complexes 8 and 10, both featuring a stereogenic boron atom were synthesized from 2-amino-1,1-diphenylethanol (5) and characterized by crystal structure analyses.
Sebastian Schlecht +2 more
doaj +2 more sources
pKa engineering of a near-infrared fluorescent probe for sensitive imaging of oxidative stress in atherosclerotic plaques. [PDF]
Smart MolA pKa‐engineered near‐infrared fluorescent probe (DCM‐2F‐B) enables sensitive imaging of oxidative stress in atherosclerotic plaques. Difluoro substitution lowers the phenolic hydroxyl pKa from 9.1 to 6.0, achieving near‐complete ionization at physiological pH.
Yu Q +10 more
europepmc +2 more sources
1,2-Bis(boronate) Arenes by Borylation Directed Borylation. [PDF]
Angew Chem Int Ed EnglBoron electrophiles derived from tetrabromo‐pyrazaboles and AlCl3 affect the regioselective vicinal double C–H borylation of a range of arenes and polycyclic aromatic hydrocarbons (PAHs). A subsequent pinacol installation step then affords the vicinal bis‐boronate ester‐substituted arene/PAH.
Schellbach AV +4 more
europepmc +3 more sources
Lactam enables remote boronate rearrangements to C═N bonds [PDF]
Communications ChemistryRemote boronate rearrangement of boronic acids to C═N bonds is a valuable in synthetic chemistry. Conventional approaches are constrained by the need to pre-install specialized directing groups onto the starting materials. Here, we report a lactam-driven
Jie Lei +6 more
doaj +2 more sources
Thermodynamic Preference Between Deprotonation Pathways in Boronic Acid-Based Proteasome Inhibitors: Insights from a DFT Study [PDF]
PharmaceuticalsBackground/Objectives: Boronic acid-based proteasome inhibitors (BABPIs) including Bortezomib, Ixazomib, and Delanzomib are clinically relevant anticancer agents whose mechanism of action depends on direct interaction between the boronic acid warhead and
Nikolay Toshev +4 more
doaj +2 more sources
Stereochemical Control in the Matteson Reaction. [PDF]
ChemistryThe Matteson homologation is a highly versatile method for the stereoselective insertion of carbenoids into boronic esters. Through iterative application of the process, complex chiral molecules can be synthesized. The stereoselectivity of the reaction is determined by a chiral diol incorporated in the boronic ester.
Lee HM, Hirschhäuser C.
europepmc +2 more sources
A Water-Stable Boronate Ester Cage [PDF]
, 2023 The reversible condensation of catechols and boronic acids to boronate esters is a paradigm reaction in dynamic covalent chemistry. However, facile backwards hydrolysis is detrimental for stability and has so far prevented applications for boronate-based
Florian, Beuerle +5 more
core +2 more sources
Self-assembled Dendritic Boronate Micelles as a Promising Delivery Strategy for Gemcitabine [PDF]
, 2021 A novel drug delivery system is described based on a PEG-dendritic copolymer functionalized with peripheral boronic acids, that self-assembles in the presence of catechol to afford nanometric micelles with the ability to encapsulate GEM.
Muna A., Al-Ni’mat +3 more
core +1 more source
Hydrophosphination of boron–boron multiple bonds
Chemical Science, 2020 Compounds containing boron–boron double and triple bonds are shown to undergo uncatalysed hydrophosphination reactions with diphenylphosphine.
Tom E. Stennett +4 more
openaire +3 more sources
Boronate Ester Bullvalenes [PDF]
, 2019 Boronate ester bullvalenes are now accessible in two to four operationally simple steps. This unlocks late-stage diversification through Suzuki cross-coupling reactions to give mono-, di-, and tri-substituted bullvalenes.
Thomas, Fallon +4 more
core +3 more sources