Results 11 to 20 of about 1,302 (169)

Iminosugars: promising therapeutics for influenza infection [PDF]

Critical Reviews in Microbiology, 2016
Influenza virus causes three to five million severe respiratory infections per year in seasonal epidemics, and sporadic pandemics, three of which occurred in the 20th century and are a continuing global threat.
Beatrice Ellen Tyrrell, Andrew Cameron Sayce, Kelly Lyn Warfield, Joanna Louise Miller, Nicole Zitzmann   +4 more
core   +4 more sources

The synthesis of branched sugars and iminosugars [PDF]

, 2011
Iminosugars, carbohydrate analogues in which nitrogen replaces the endocyclic oxygen, have attracted much interest due to their biological activity. Iminosugars inhibit carbohydrate-processing enzymes, thereby affecting many biological processes. Several
Parry, Loren
core   +2 more sources

Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model. [PDF]

PLoS ONE, 2016
The antiviral properties of iminosugars have been reported previously in vitro and in small animal models against Ebola virus (EBOV); however, their effects have not been tested in larger animal models such as guinea pigs.
Joanna L Miller, Simon G Spiro, Stuart D Dowall, Irene Taylor, Antony Rule, Dominic S Alonzi, Andrew C Sayce, Edward Wright, Emma M Bentley, Ruth Thom, Graham Hall, Raymond A Dwek, Roger Hewson, Nicole Zitzmann   +13 more
doaj   +2 more sources

The synthesis and biology of iminosugars and their precursors [PDF]

, 2016
Iminosugars are carbohydrate mimics, where the endocyclic ring oxygen has been replaced by nitrogen. This substitution affords these compounds their inhibitory activity towards sugar-processing enzymes (glycosidases) and, as a consequence, their ...
Ayers, Benjamin James, Ayers, Benjamin
core   +2 more sources

The mechanism of action of iminosugars as antiretrovirals [PDF]

, 2016
Iminosugars are a class of molecules that resemble sugars but for the substitution of a nitrogen for the oxygen in the hemiacetal ring. Several iminosugars are inhibitors of cellular glycosidase enzymes in the N-linked glycan processing pathway ...
Spiro, S, Spiro, Simon
core   +3 more sources

Diastereoselective Synthesis of Iminosugars using g-Siloxyallyltins

, 2005
Communication par affiche intitulée (présentée par J.-P.
Beaudet, I., Le Grognec, E., Chevallier, J.F., Quintard, J.-P.   +3 more
core   +7 more sources

A General Synthesis of Iminosugars. [PDF]

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ciaran, McDonnell, Linda, Cronin, Julie L, O'Brien, Paul V, Murphy   +3 more
openaire   +2 more sources

Toward the Identification of Novel Antimicrobial Agents: One-Pot Synthesis of Lipophilic Conjugates of N-Alkyl d- and l-Iminosugars

Marine Drugs, 2020
In the effort to improve the antimicrobial activity of iminosugars, we report the synthesis of lipophilic iminosugars 10a–b and 11a–b based on the one-pot conjugation of both enantiomeric forms of N-butyldeoxynojirimycin (NBDNJ) and N ...
Anna Esposito, Daniele D’Alonzo, Stefano D’Errico, Eliana De Gregorio, Annalisa Guaragna   +4 more
doaj   +1 more source

Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes.

PLoS Neglected Tropical Diseases, 2016
It has long been thought that iminosugar antiviral activity is a function of inhibition of endoplasmic reticulum-resident α-glucosidases, and on this basis, many iminosugars have been investigated as therapeutic agents for treatment of infection by a ...
Andrew C Sayce, Dominic S Alonzi, Sarah S Killingbeck, Beatrice E Tyrrell, Michelle L Hill, Alessandro T Caputo, Ren Iwaki, Kyoko Kinami, Daisuke Ide, J L Kiappes, P Robert Beatty, Atsushi Kato, Eva Harris, Raymond A Dwek, Joanna L Miller, Nicole Zitzmann   +15 more
doaj   +1 more source

Synthesis of a New β-Galactosidase Inhibitor Displaying Pharmacological Chaperone Properties for GM1 Gangliosidosis

Molecules, 2022
GM1 gangliosidosis is a rare lysosomal disease caused by the deficiency of the enzyme β-galactosidase (β-Gal; GLB1; E.C. 3.2.1.23), responsible for the hydrolysis of terminal β-galactosyl residues from GM1 ganglioside, glycoproteins, and ...
Francesca Clemente, Macarena Martínez-Bailén, Camilla Matassini, Amelia Morrone, Silvia Falliano, Anna Caciotti, Paolo Paoli, Andrea Goti, Francesca Cardona   +8 more
doaj   +1 more source