Results 151 to 160 of about 16,862 (246)

Pharmacological chaperones mitigate noise-induced hearing loss by attenuating sustained PERK activation. [PDF]

Proc Natl Acad Sci U S A
Hong JW, Min H, Kim S, Song HG, Choi Y, Kim CH, Bok J, Gee HY.   +7 more
europepmc   +1 more source

Polyphyllin I Alleviates Alcoholic Liver Disease via Modulation of the Phosphodiesterase 6D–Cyclic Guanosine Monophosphate–Protein Kinase G Axis

Phytotherapy Research, EarlyView.
ABSTRACT Alcoholic liver disease (ALD) is a multifaceted disorder in which oxidative injury, iron‐dependent ferroptosis, steatosis, and inflammation are closely intertwined. Consequently, therapeutic strategies targeting a single pathway often produce limited clinical benefits.
Hongyan Feng, Xuelian Yuan, Yawen Xie, Zhenni Xia, Zhaohui Guo, Xuesong Liu, Rong Li, Wenliang Wang   +7 more
wiley   +1 more source

Unifying perspectives on the activity and genotypic targeting of pharmacological chaperones. [PDF]

J Biol Chem
Tedman A, Goel M, Shah S, Schlebach JP.
europepmc   +1 more source

Molecular glues: Recent advances in cereblon substrate identification and mechanistic insights

Smart Molecules, EarlyView.
Molecular glues exert diverse core biological functions by inducing or stabilizing protein–protein interactions, extending far beyond the traditional scope of targeted protein degradation. Key breakthroughs include expanded cereblon substrate recognition, sustained G protein‐coupled receptor megacomplex signaling, and the first orthosteric molecular ...
Qingyun Guan, Xiaoyu Shi, Qian Yang, Xiangyi Jiang, Xinyong Liu, Peng Zhan   +5 more
wiley   +1 more source

Neuronal Inhibition in Epilepsy: Native Human GABA-A Receptors and Pharmacological Chaperones Restoring Expression of Disease Associated Variants. [PDF]

Epilepsy Curr
Durisic N, Borges K.
europepmc   +1 more source

En face localization of retinal telangiectatic capillaries using OCT compared with ICG angiography in chronic vascular macular oedema

Acta Ophthalmologica, EarlyView.
Abstract Purpose Retinal telangiectatic capillaries (TelCaps) are microvascular abnormalities associated with chronic vascular macular oedema and suboptimal response to intravitreal therapy. Targeted laser photocoagulation is beneficial but requires precise localization using indocyanine green angiography (ICG‐A), the reference standard. However, ICG‐A
Lucas Unger, Bénédicte Dupas, Mohamed Bennani, Daniela Castro Farias, Jean‐François Girmens, Aude Couturier, Michel Paques, Marie‐Noëlle Delyfer   +7 more
wiley   +1 more source

Itraconazole and posaconazole, inhibitors of NPC1 sterol transport, act as pharmacological chaperones after washout. [PDF]

J Biol Chem
Wang WA, Ma CJ, Steinfeld N, Maxfield FR.   +3 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Regulation of Cannabinoid and Opioid Receptor Levels by Endogenous and Pharmacological Chaperones. [PDF]

J Pharmacol Exp Ther
Gupta A, Gomes I, Osman A, Fujita W, Devi LA.   +4 more
europepmc   +1 more source

Pharmacological chaperones of ATP-sensitive potassium channels: Mechanistic insight from cryoEM structures. [PDF]

Mol Cell Endocrinol, 2020
Martin GM, Sung MW, Shyng SL.
europepmc   +1 more source