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Designation of imidazole-containing dipeptides as pharmacological chaperones
Human & Experimental Toxicology, 2010We review the dichotomous regulatory roles of natural imidazole-containing peptidomimetics (N-acetylcarnosine [NAC], carcinine, non-hydrolized carnosine) in maintaining skin homeostasis that determines whether keratinocytes survive or undergo apoptosis in response to various insults and in the development of skin diseases. General strategies addressing
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Pharmacological Chaperoning in Fabry Disease
2011Fabry Disease is an X-‐linked lysosomal storage disorder characterized by a variety of symptoms including hypohydrosis, seizures, cardiac abnormalities, skin lesions, and chronic pain. These symptoms stem from a lack of functional endogenous α-‐ Galactosidase A (α-GAL), which leads to an accrual of its natural substrate.
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Cloramphenicol: A pharmacological chaperone?
Molecular Genetics and Metabolism, 2012Roberto Giugliani +6 more
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A pharmacological chaperone on the horizon
Nature Reviews Nephrology, 2016Martina Gaggl, Gere Sunder-Plassmann
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Advances in the Development of Pharmacological Chaperones for the Mucopolysaccharidoses
International Journal of Molecular Sciences, 2020Alexander Rodríguez-López +1 more
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