Results 171 to 180 of about 858,870 (284)

Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics. [PDF]

, 2020
Do, Thao P, Giacomini, Kathleen M, Huang, Shiew-Mei, Krauss, Ronald M, Kusuhara, Hiroyuki, Sugiyama, Yuichi, Unadkat, Jashvant D, Yee, Sook Wah   +7 more
core   +2 more sources

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Glucocorticoids Do Not Affect the Vascular Component of TRP-Mediated Neurogenic Skin Inflammation

Journal of Inflammation Research
Heleen Marynissen, Jan de Hoon Center for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, BelgiumCorrespondence: Heleen Marynissen, Center for Clinical Pharmacology, Department of Pharmaceutical and ...
Marynissen H, de Hoon J
doaj  

Botanical characterization, phytochemistry, biosynthesis, pharmacology clinical application, and breeding techniques of the Chinese herbal medicine Fritillaria unibracteata. [PDF]

Front Pharmacol
Zhang Y, Han H, Li D, Fan Y, Liu M, Ren H, Liu L.   +6 more
europepmc   +1 more source

Aptamer Functionalized Hydrogel Dressings for Post‐Surgery Tumor Recurrence Inhibition and Tissue Reconstruction

Advanced Functional Materials, EarlyView.
Post‐surgical tumor therapy struggles with recurrence and inefficient healing. Anti‐tumor DNA aptamer functionalized gelatin hydrogels, Apt‐GelMA, simultaneously address both issues by suppressing tumor regrowth via targeted tumor cell inhibition and enhancing wound healing through improved cell adhesion and migration. Their biocompatibility, stability,
Tianyue Li, Xin‐Yi Qian, Zi‐Yuan Li, Hao‐Wen Li, Poh‐Ching Tan, Chenghuizi Hu, Jiajun Jin, Shuang‐Bai Zhou, Qing‐Feng Li, He Tian, Junji Zhang, Itamar Willner   +11 more
wiley   +1 more source

Armeniacae semen amarum: a review on its botany, phytochemistry, pharmacology, clinical application, toxicology and pharmacokinetics. [PDF]

Front Pharmacol
Tang S, Wang M, Peng Y, Liang Y, Lei J, Tao Q, Ming T, Shen Y, Zhang C, Guo J, Xu H.   +10 more
europepmc   +1 more source

Selective Laser Sintering 3D Printing of Drug‐Loaded Intravitreal Implants

Advanced Functional Materials, EarlyView.
Selective laser sintering enables the fabrication of biodegradable and biocompatible intravitreal implants with tunable microstructures for sustained drug delivery. By modulating laser scanning speed, the polymer matrix architecture is engineered to control the release kinetics of dexamethasone and riboflavin over several months. This approach offers a
Iria Seoane‐Viaño, Carlos Bendicho‐Lavilla, Haya Alfassam, Bárbara Blanco‐Fernández, Abdul W. Basit, Francisco J. Otero‐Espinar   +5 more
wiley   +1 more source

A review of the pharmacology, clinical outcomes, and real-world effectiveness, safety, and non-contraceptive effects of NOMAC/E2. [PDF]

Eur J Obstet Gynecol Reprod Biol X
Fruzzetti F, Machado RB, Lete I, Patel A, Boolell M.   +4 more
europepmc   +1 more source

3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research

Advanced Functional Materials, EarlyView.
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram, Majd Machour, Janette Zavin, Roy Meretzki, Reut Lev‐Ari, Shulamit Levenberg   +5 more
wiley   +1 more source

Multifunctional Protein Eutectogels Based on Polyphenolic: Zwitterionic Low‐Transition‐Temperature Mixtures

Advanced Functional Materials, EarlyView.
This work presents the first example of multifunctional protein eutectogels based on a tannic acid: betaine low‐transition‐temperature mixture, exhibiting elastomeric behavior, strong adhesion to various substrates, including biological tissues, and notable anti‐inflammatory properties derived from the natural polyphenol and zwitterion.
Sergio Martin‐Saldaña, Alberto de León, María de la Mata, Nikolaos Politakos, Jorge L. Olmedo‐Martínez, Alejandro J. Müller, Ana Beloqui, Marcelo Calderón, Matias L. Picchio   +8 more
wiley   +1 more source