Results 251 to 260 of about 898,450 (282)

Prescription Support Practice for Pharmacy Students: Pre-Post Educational Intervention Study.

open access: yesJMIR Med Educ
Aizawa F   +10 more
europepmc   +1 more source

Geriatric Clinical Pharmacology

Cardiology Clinics, 1986
Age-related physiologic changes may significantly alter drug disposition and dynamics in the elderly. This is especially important for cardiovascular drugs, because they are used with such high frequency in the geriatric population. Alterations in the pharmacokinetics and pharmacodynamics of several drugs used to treat cardiovascular disease have been ...
M L, Rocci, P H, Vlasses, W B, Abrams
openaire   +2 more sources

Clinical Pharmacology

JAMA: The Journal of the American Medical Association, 1989
The issue of what drug effects to measure, surrogate end points, has been emphasized by two recent clinical trials. Several recent studies have given us new information about why different people react so differently to the same dose of the same medicine.
openaire   +5 more sources

Clinical Pharmacology of Inodilators

Journal of Cardiovascular Pharmacology, 1989
Recent advances in our knowledge of heart failure have shown that both a central and a peripheral factor are involved in this syndrome. Therefore, the ideal drug should combine the properties of a positive inotropic agent with those of a peripheral vasodilator; many drugs recently introduced into clinical practice have been shown to present both of ...
DEI CAS, Livio   +2 more
openaire   +3 more sources

Clinical Pharmacology of Cilazapril

Drugs, 1989
In clinical pharmacology studies, cilazapril, after its bioactivation to cilazaprilat, was characterised as a potent, reversible angiotensin converting enzyme (ACE) inhibitor with a terminal half-life of 30 to 50 hours, which is consistent with saturable binding to ACE.
C H, Kleinbloesem   +3 more
openaire   +3 more sources

Investigative Clinical Pharmacology

Clinical Pharmacology & Therapeutics, 2011
Clinical pharmacology is an essential discipline in the development of new medicines, but the closely specified requirements of pharmaceutical industry protocols and regulatory reviewers have limited the opportunities for curiosity-driven research. Realization is growing that there is so much that is not known about the mechanisms underlying human ...
openaire   +2 more sources

Clinical Pharmacology

2022
This chapter provides an overview of the general principles and miscellaneous topics of clinical pharmacology that are relevant to pain medicine. This involves the World Health Organization (WHO) analgesic ladder which is mainly used for acute and cancer pain.
Sabina Bachtold   +6 more
openaire   +1 more source

Rapacuronium: clinical pharmacology

European Journal of Anaesthesiology, 2001
The need for a rapid-acting non-depolarizing neuromuscular blocking agent with a short duration of action resulted in the synthesis of rapacuronium. The onset of maximum block with rapacuronium occurs in 60-90 s with doses of 1.5-2.5 mg kg-1 with a duration of clinical relaxation of 15-30 min.
R K, Mirakhur, K C, McCourt
openaire   +2 more sources

Omapatrilat: Clinical pharmacology

Drugs of Today, 2000
Omapatrilat is the most clinically advanced member of a new class of cardiovascular agents known as vasopeptidase inhibitors. Omapatrilat acts by inhibiting two key enzymes responsible for blood pressure regulation: neutral endopeptidase and angiotensin-converting enzyme.
openaire   +2 more sources

Clinical pharmacology: Foscarnet

The American Journal of Medicine, 1992
Foscarnet exerts its antiviral effects via reversible inhibition of viral polymerases. Pharmacodynamic data indicate that herpesvirus and human immunodeficiency virus replication is inhibited by therapeutically achievable concentrations of foscarnet; however, the concentrations of foscarnet required for such inhibition have been found to vary widely ...
openaire   +2 more sources

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