Results 31 to 40 of about 9,387,370 (281)
Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde, 2021 Objective: The aim of this work was to evaluate the impact of an integrative activity based on clinical practices in disciplines of the basic and health care curriculum of an undergraduate pharmacy school.
Francisco A. FARIAS-FILHO +3 more
doaj +1 more source
Clinical pharmacology of deoxycoformycin [PDF]
Blood, 1981 Deoxycoformycin (DCF) is an inhibitor of adenosine deaminase (ADA). Twenty-one courses of DCF were administered to 13 patients ranging in age from 15 to 78 yr. Eight patients had T-cell disorders, and five patients had non-T-cell malignancies. The i.v. bolus dose was escalated from 5 to 30 mg/sq m/day, and the duration of the courses ranged from 1 to 5
DW Kufe, PP Major, Ram P. Agarwal
openaire +4 more sources
Clinical Pharmacology of Antibody-Drug Conjugates
Antibodies, 2021 Antibody-drug conjugates (ADCs) are biopharmaceutical products where a monoclonal antibody is linked to a biologically active drug (a small molecule) forming a conjugate.
Iftekhar Mahmood
doaj +1 more source
Moxonidine: Pharmacology, Clinical Pharmacology and Clinical Profile
Blood Pressure, 1998 Management strategies in hypertension evolve in response to an increased understanding of underlying pathophysiological processes and developments and refinements in drug treatments. Recent research has identified the regulatory role of the imidazoline (I1) receptor in sympathetic outflow and blood pressure regulation and this has led to the ...
openaire +3 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Integration of computer-simulated practical exercises into undergraduate medical pharmacology education at Mulungushi University, Zambia [PDF]
Journal of Educational Evaluation for Health Professions, 2020 Purpose This study was conducted to determine whether a computer simulation of practical exercises in undergraduate medical pharmacology led to the realization of the intended learning outcomes.
Christian Chinyere Ezeala
doaj +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Review on Pharmacology of Cisplatin: Clinical Use, Toxicity and Mechanism of Resistance of Cisplatin
Biomedical & Pharmacology Journal, 2019 Cisplatin is a chemotherapeutic drug that has been used in the treatment of various types of human cancers such as ovarian, lung, head and neck, testicular and bladder.
S. Aldossary
semanticscholar +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals
British Journal of Pharmacology, 2019 The nutraceuticals market is vast, encompassing many different products with inconsistent levels of evidence available to support their use. This overview represents a Western perspective of the nutraceuticals market, with a brief comparison with that in
E. Williamson, Xinmin Liu, A. Izzo
semanticscholar +1 more source