Results 11 to 20 of about 2,320,535 (398)

The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors

British Journal of Pharmacology, 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and nearly 6000 interactions
S. Alexander, Doriano Fabbro, E. Kelly, A. Mathie, John A. Peters, E. Veale, J. Armstrong, E. Faccenda, S. Harding, J. Davies, Annie Beuve, Peter Brouckaert, C. Bryant, John C Burnett, R. Farndale, A. Friebe, John Garthwaite, Adrian J Hobbs, Gavin E. Jarvis, D. Koesling, Michaela Kuhn, David MacEwan, T. Monie, Lincoln R Potter, M. Russwurm, H. Schmidt, J. Stasch, Scott A Waldman   +27 more
semanticscholar   +1 more source

Evaluating the Effects of Different Doses of Vitamin B2 and Single Dose of Vitamin B12 Against Myelosuppression Induced by Cyclophosphamide in Experimental Rats

Iraqi Journal of Pharmaceutical Sciences, 2020
Cyclophosphamide is chemotherapeutic agent that utilized for the treatment of different malignancies; however its’ used associated with numerous adverse effects. Vitamin B2 and vitamin B12 suggested having myeloprotective effect.
Waleed K. Ghanim, nada N. Al-Shawi
doaj   +1 more source

Pharmacology of antihistamines [PDF]

Indian Journal of Dermatology, 2011
H1-antihistamines, the mainstay of treatment for urticaria, were developed from anticholinergic drugs more than 70 years ago. They act as inverse agonists rather than antagonists of histamine H1-receptors which are members of the G-protein family.
Martin K. Church, Martin K. Church, Diana S. Church, Diana S. Church   +3 more
openaire   +8 more sources

Network Pharmacology Approach for Medicinal Plants: Review and Assessment

Pharmaceuticals, 2022
Natural products have played a critical role in medicine due to their ability to bind and modulate cellular targets involved in disease. Medicinal plants hold a variety of bioactive scaffolds for the treatment of multiple disorders.
F. Noor, Muhammad Tahir ul Qamar, U. Ashfaq, Aqel Albutti, A. S. Alwashmi, M. Aljasir   +5 more
semanticscholar   +1 more source

A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

eLife, 2023
The cardiac IKs ion channel comprises KCNQ1, calmodulin, and KCNE1 in a dodecameric complex which provides a repolarizing current reserve at higher heart rates and protects from arrhythmia syndromes that cause fainting and sudden death.
Magnus Chan, Harutyun Sahakyan, Jodene Eldstrom, Daniel Sastre, Yundi Wang, Ying Dou, Marc Pourrier, Vitya Vardanyan, David Fedida   +8 more
doaj   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

British Journal of Pharmacology, 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective ...
Stephen P. H. Alexander, A. Christopoulos, A. Davenport, E. Kelly, A. Mathie, J. A. Peters, E. Veale, J. Armstrong, E. Faccenda, S. Harding, Adam J. Pawson, C. Southan, J. Davies, M. Abbracchio, Wayne Alexander, Khaled Al-hosaini, M. Bäck, N. Barnes, R. Bathgate, J. Beaulieu, K. Bernstein, B. Bettler, N. Birdsall, V. Blaho, F. Boulay, C. Bousquet, H. Bräuner‐Osborne, G. Burnstock, G. Calo’, J. Castaño, K. Catt, S. Ceruti, P. Chazot, N. Chiang, B. Chini, J. Chun, A. Cianciulli, O. Civelli, L. Clapp, R. Couture, Z. Csaba, C. Dahlgren, G. Dent, K. D. Singh, S. Douglas, P. Dournaud, S. Eguchi, E. Escher, E. Filardo, T. Fong, M. Fumagalli, R. Gainetdinov, M. Gasparo, C. Gerard, M. Gershengorn, F. Gobeil, T. Goodfriend, C. Goudet, K. Gregory, A. Gundlach, J. Hamann, J. Hanson, R. Hauger, D. Hay, A. Heinemann, M. Hollenberg, N. Holliday, M. Horiuchi, D. Hoyer, L. Hunyady, A. Husain, A. IJzerman, T. Inagami, K. Jacobson, R. Jensen, R. Jockers, Deepa Jonnalagadda, S. Karnik, K. Kaupmann, Jacqueline R. Kemp, C. Kennedy, Y. Kihara, T. Kitazawa, P. Kozielewicz, H. Kreienkamp, J. Kukkonen, T. Langenhan, K. Leach, D. Lecca, John D. Lee, S. Leeman, J. Leprince, Xaria X. Li, Thomas L. Williams, S. Lolait, A. Lupp, Robyn G. C. Macrae, J. Maguire, J. Mazella, C. McArdle, S. Melmed, M. Michel, L. Miller, V. Mitolo, B. Mouillac, C. Müller, Philip Murphy, J. Nahon, T. Ngo, X. Norel, Duuamene Nyimanu, A. O'Carroll, S. Offermanns, M. Panaro, M. Parmentier, R. Pertwee, J. Pin, E. Prossnitz, M. Quinn, R. Ramachandran, Manisha Ray, R. Reinscheid, P. Rondard, G. Rovati, C. Ruzza, G. Sanger, T. Schöneberg, G. Schulte, S. Schulz, D. Segaloff, C. Serhan, Leigh A. Stoddart, Y. Sugimoto, R. Summers, V. P. Tan, D. Thal, Walters Thomas, P. Timmermans, Kalyan C. Tirupula, G. Tulipano, Hamiyet Unal, T. Unger, C. Valant, P. Vanderheyden, D. Vaudry, H. Vaudry, J. Vilardaga, C. Walker, Ji Ming Wang, D. Ward, H. Wester, G. Willars, T. Woodruff, Chengcan Yao, R. Ye   +154 more
semanticscholar   +1 more source

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

Pharmacological Reviews, 2021
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian central nervous system, are mediated via signaling by ionotropic glutamate receptors (iGluRs).
K. Hansen, L. Wollmuth, D. Bowie, Hiro Furukawa, F. Menniti, A. Sobolevsky, G. Swanson, Sharon A. Swanger, I. Greger, T. Nakagawa, C. McBain, V. Jayaraman, C. Low, M. Dell’Acqua, J. Diamond, Chad R. Camp, Riley E. Perszyk, Hongjie Yuan, S. Traynelis   +18 more
semanticscholar   +1 more source

Pharmacology [PDF]

, 2010
Headache treatment has been based primarily on experiences with non-specific drugs such as analgesics, non-steroidal anti-inflammatory drugs, or drugs that were originally developed to treat other diseases, such as beta-blockers and anticonvulsant medications. A better understanding of the basic pathophysiological mechanisms of migraine and other types
B S K Kamath, Sarah Turle
openaire   +4 more sources

Recent advancements in total intravenous anaesthesia and anaesthetic pharmacology

Indian Journal of Anaesthesia, 2023
Target-controlled infusion pumps and depth of anaesthesia monitors have made total intravenous anaesthesia (TIVA) easy, safe, and precise. The merits of TIVA were highlighted during the coronavirus disease 2019 (COVID-19) pandemic, confirming its ...
Sukhminder Jit Singh Bajwa, Stalin Vinayagam, Surekha Shinde, Shital Dalal, Jessy Vennel, Samridhi Nanda   +5 more
doaj   +1 more source

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

Journal of Cheminformatics, 2014
BackgroundModern medicine often clashes with traditional medicine such as Chinese herbal medicine because of the little understanding of the underlying mechanisms of action of the herbs. In an effort to promote integration of both sides and to accelerate
Jinlong Ru, Peng Li, Jinan Wang, W. Zhou, Bohui Li, Chao Huang, Pidong Li, Zihu Guo, W. Tao, Yinfeng Yang, Xue Xu, Yan Li, Yonghua Wang, Ling Yang   +13 more
semanticscholar   +1 more source