Results 71 to 80 of about 6,245 (194)
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso +3 more
wiley +1 more source
Pediatric Rheumatology Online JournalBackground Adalimumab (ADM) in children with juvenile idiopathic arthritis (JIA) is usually dosed using fixed weight-based bands (label dosing: 20 mg for 9 mg/L further increased proportion with target exposure to 56–63% while keeping the proportion of ...
Dominic S. Bräm +8 more
doaj +1 more source
A tutorial on pharmacometric Markov models
CPT: Pharmacometrics & Systems PharmacologyAbstractThe Markov chain is a stochastic process in which the future value of a variable is conditionally independent of the past, given its present value. Data with Markovian features are characterized by: frequent observations relative to the expected changes in values, many consecutive same‐category or similar‐value observations at the individual ...
Qing Xi Ooi +2 more
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Bipolar Disorders, Volume 28, Issue 5, August 2026.ABSTRACT Objective Bipolar disorder (BD) often emerges during mid‐adolescence and young adulthood, and leads to functional and social impairment, with a prevalence of 0.87% among Dutch youth. Lithium, the first‐line BD maintenance treatment, stabilizes mood, prevents suicide, and is well tolerated, yet its use has declined as long‐term second ...
Ravish N. Gangapersad +8 more
wiley +1 more source
npj Systems Biology and ApplicationsElranatamab, an approved bispecific antibody (BsAb) for relapsed/refractory multiple myeloma, forms an immune synapse between the T-cell CD3 marker and B-cell maturation antigen (BCMA) on myeloma cells. Circulating soluble BCMA (sBCMA) is associated with
Kamrine E. Poels +5 more
doaj +1 more source
Semimechanistic Modeling to Guide Venetoclax Coadministration with Ritonavir and Digoxin
Clinical and Translational Science, 2020 Venetoclax is a cytochrome P450, family 3, subfamily A (CYP3A) substrate and was shown to inhibit P‐gp efflux transporters in vitro. To quantify the impact of CYP3A inhibition by ritonavir on venetoclax disposition and P‐gp inhibition by venetoclax on ...
Ali A. Alhadab +2 more
doaj +1 more source
CPT: Pharmacometrics and Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, 2012 Welcome to the first issue of CPT: Pharmacometrics and Systems Pharmacology (CPT:PSP), a new journal from the American Society for Clinical Pharmacology and Therapeutics. CPT:PSP is a cross‐disciplinary journal devoted to publishing advances in quantitative, model‐based approaches as applied in pharmacology, (patho)physiology, and disease to aid the ...
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British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2390-2402, July 2026.Aims The repurposed use of favipiravir in COVID‐19 has been reported to have limited clinical efficacy, yet it has been widely used in some countries. Favipiravir causes mutagenesis in RNA viruses, and it is currently unknown whether it may have a measurable effect on the virus in humans.
Akosua A. Agyeman +9 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2016-2027, July 2026.Abstract Health care is shifting towards a digital‐guided system, integrating digital diagnostics, biomarkers and therapeutics in many care pathways. However, despite rapid technological advancement and preliminary adoption accelerated by the COVID‐19 pandemic, a significant implementation gap persists. This narrative review explores the causes of this
Mees H. P. Stoop +3 more
wiley +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2028-2048, July 2026.This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst +8 more
wiley +1 more source