Results 201 to 210 of about 13,822,676 (240)

GC–MS‐Based Phytochemical Profiling and Integrated Evaluation of Antioxidant, Antibacterial, and In Silico Studies of Kumaun Himalayan Strobilanthes Species

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Himalayan Strobilanthes species: phytochemical profiling, bioactivities, and In silico Studies. ABSTRACT Five Strobilanthes species indigenous to the Kumaun Himalayan region of Uttarakhand, India, have been historically employed in traditional medicine to treat bacterial infections, inflammatory conditions, and respiratory ailments, but remain largely ...
Sakshi Negi, Ravendra Kumar, Vaishnavi Rawat, Pooja Bargali, Aashish Kumar Sagar, Stefania Garzoli, Riddhiman Lahiri, Shilpi Rawat, Avdhesh Kumar, Manmohan Singh Rawat, Jolanta Maslowiecka, Valery A. Isidorov, Dharmendra S. Rawat   +12 more
wiley   +1 more source

De Novo Molecular Design and Bioactivity Prediction of Novel Hexahydroquinolines as <i>Plasmodium falciparum</i> Calcium-Dependent Protein Kinase 4 (CDPK4) Inhibitors. [PDF]

Bioinform Biol Insights
Oduselu GO, Bodun DS, Ajani OO, Conway DJ, Amenga-Etego LN, Oyibo W, Awandare GA.   +6 more
europepmc   +1 more source

Synthesis and Antifungal Activities of Perillyl Alcohol Based 1,3,4‐Thiadiazole‐Thioether Compounds

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A series of perillyl alcohol‐derived 1,3,4‐thiadiazole‐thioether compounds were designed, synthesized, and evaluated for their antifungal activities. Compound V15 was identified as the most potent derivative, demonstrating superior efficacy against G.
Yanlin Xiong, Yun Zhang, Yucheng Cui, Meijuan Hu, Meifang Zhuo, Wengui Duan, Qijin Mo   +6 more
wiley   +1 more source

Building structure activity relationships to avoid toxicity due to unwanted central nervous system ion channel activity. [PDF]

Toxicol Sci
Zolkiewski LAK, Rockley KL, Roberts RA, Jennings HG, Maizières MA, Jones K, McDonagh JL, Newman K, Griffen EJ, Stacey JE, Morton MJ.   +10 more
europepmc   +1 more source

Design, Synthesis, Molecular Dynamics, and In Vitro Evaluation of Isatin‐Based Quinazoline Derivatives as Potential Antidiabetic Agents

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A series of substituted indolo[2,1‐b]quinazoline‐6,12‐diones (SJ1‐SJ8) has been studied for their possible α‐amylase inhibition property as an antidiabetic lead compound. The most potent inhibitory activity among the tested derivatives was showed by SJ2 (IC50 = 18.49 ± 0.06 µM), similar to the reference drug acarbose (IC50 = 16.26 ± 0.02 µM).
Sahil Jaidka, Ankush Kumar, Christopher Basumatary, Thakur Gurjeet Singh, Rohit Bhatia   +4 more
wiley   +1 more source

Integrated experimental and computational evaluation of atractylenolide III from Tubipora musica for anticancer lead identification. [PDF]

Sci Rep
Noreldeen HAA.
europepmc   +1 more source

A Thiosemicarbazone Schiff Base and Its Titanium(IV) Complexes: Spectral Analysis, DFT Studies, and Biological Evaluation

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
DFT computations are used to analyze the electronic structure, stability, and reactivity profiles of a new Schiff base ligand and its Ti(IV) complexes and are characterized by elemental analysis, IR, 1H NMR, 13C NMR, and mass spectrometry and screened for antimicrobial activities against E. coli, S. aureus, ESBL, MRSA, Mtb, A.
Priyanka Ghanghas, Anshul Yadav, Astha Kamboj, Anita Choudhary, Manjinder Kour, Dinesh Kumar, Kavita Poonia   +6 more
wiley   +1 more source

Exploring the Anticancer Potential of Novel Piperidine‐Embedded Isoxazol–Triazole Conjugates Against MCF‐7 Human Breast Adenocarcinoma Cell Line: Design, Synthesis, In Silico, and In Vitro Investigations

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Novel piperidine–embedded isoxazol–triazole conjugates (6a‐6o) were designed, synthesized, and evaluated for anticancer activity against MCF‐7 breast cancer cells, with selectivity assessed using noncancerous HEK293 cells. Compound 6m showed the most potent antiproliferative activity (GI50 < 10 µg/mL; SI > 5), comparable to doxorubicin, highlighting ...
Jay R. Ghonia, Jigisha Parikh, Bharatkumar Z. Dholakiya   +2 more
wiley   +1 more source

Underexplored Ligand-Binding Features of FabI From Staphylococcus aureus and Escherichia coli: A Comparative Pharmacophoric Modeling and Surface Mapping Approach. [PDF]

ChemMedChem
Leite PTTF, Ocarino LHS, Veríssimo GC, Fernandes PO, Pereira DF, Oliveira FKME, Marbán-González A, Medina-Franco JL, Serafim MSM, Kronenberger T, Maltarollo VG.   +10 more
europepmc   +1 more source

Synthesis, Characterization, and Biological Assessment of 2‐Methoxynicotinonitrile Derivatives

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
We report the synthesis of new 2‐methoxy‐3‐cyanopyridine derivatives via the nucleophilic aromatic substitution pathway, along with their crystal structure determination and preliminary biological evaluation. The new synthetic conversion described here demonstrates a practical method of preparing structurally diverse 2‐methoxy‐3‐cyanopyridines and ...
Eman Sulaiman, Eman Al‐Masri, Maram B. Alhawarri, Mohammad M. Ibrahim, Mahmoud Al‐Refai, Basem F. Ali, Ali Shuaib   +6 more
wiley   +1 more source