Results 211 to 220 of about 13,822,676 (240)

Influence of N-Functionalization of Amiridine on the Biological Activity of Its Conjugates as Multitarget Agents for Potential Treatment of Alzheimer's Disease. [PDF]

ChemMedChem
Makhaeva GF, Astakhova TY, Grishchenko MV, Shteinberg TS, Kovaleva NV, Boltneva NP, Rudakova EV, Pronkin PG, Timokhina EN, Radchenko EV, Shchegolkov EV, Burgart YV, Saloutin VI, Charushin VN, Richardson RJ.   +14 more
europepmc   +1 more source

Design, Synthesis, and Antifungal Activity of Natural Furan Carboxylic Acid Derivatives as Potential Succinate Dehydrogenase Inhibitors

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A series of furanamide derivatives were designed and synthesized. Among these compounds, those containing the trifluoromethyl (─CF3) group exhibited the most potent antifungal activity. Notably, compounds 3m and 6b showed particularly strong effects, and their mechanism of action was further investigated.
Hongxin Luo, Yusen Wang, Yanchang Shi, Chengna Dong, Yadong Song, Qilin Zhang, Zhiqiang Hu, Yukun Qin   +7 more
wiley   +1 more source

Computational investigation for exploring botanical ingredients as potential negative allosteric modulators targeting metabotropic glutamate receptor 5. [PDF]

Res Pharm Sci
Singh P, Patra J, Saeedan AS, Aldossary SA, Ansari MN.   +4 more
europepmc   +1 more source

Development of Dithioacetal‐Modified Dihydropyrimidone Derivatives with Potential Anti‐Inflammatory Activity for Inflammatory Bowel Disease

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This study designed and synthesized dithioacetal‐modified dihydropyrimidinone derivatives (30). Compound D3 showed optimal anti‐inflammatory activity, inhibiting the MAPK/NF‐κB pathway, reducing NO secretion (IC50 = 1.2 µM), and ameliorating DSS‐induced acute colitis in mice, offering a new candidate for inflammatory bowel disease therapy.
Jian‐Wei Jiang, Rui Dong, Qi Cao, Huan Wang, Si‐Yu Li, Guo‐Ping Zhang, Qian‐Yi Wang   +6 more
wiley   +1 more source

Pharmacophore-Based QSAR Model of Multi Scaffolds as NAMPT Inhibitors & Scaffold Diversity Analysis. [PDF]

Molecules
Lee S, Zheng M, Kim K, Chun KH.
europepmc   +1 more source

Free Phenolic Hydroxyl Groups Govern the Anticancer Activity of α‐Mangostin: A Structure–Activity Relationship Insight

ChemFoodChem, Volume 2, Issue 3, September 2026.
Free phenolic hydroxyl groups in the chemical structure of the natural xanthone α‐mangostin (MGT) contribute positively to achieving the anticancer profile against murine colon cancer, murine triple negative breast cancer, and human osteosarcoma cancer. ABSTRACT The α‐mangostin (MGT) is a natural xanthone obtained from the pericarp of mangosteen fruit (
Otávio Augusto Chaves, Afonso Santine M. M. Velez, Lívia Stenico, Douglas Chaves de Alcântara Pinto, Debora Decote‐Ricardo, Eliezer Avila Gandra, Marco Edilson Freire de Lima, Carlos Serpa   +7 more
wiley   +1 more source

An integrative computational and experimental evaluation of natural compounds with potential to target LuxS in Klebsiella pneumoniae. [PDF]

Arch Microbiol
Mamosebo MJ, Ayrga S, Madhi SA, Khan S.
europepmc   +1 more source

Design, Synthesis, and Biological Evaluation of Benzimidazol‐2‐One Hybrids as Potential Anti‐Alzheimer's Disease Agents

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder for which single‐target therapies often provide insufficient benefit, motivating the development of multi‐target‐directed ligands (MTDLs). In this study, a novel series of benzimidazolone‐based hybrids incorporating piperazine, coumarin, and triazole moieties was designed,
Fatih Yılmaz, Emre Menteşe, Ozan Emre Eyüpoğlu, Bahittin Kahveci, Mustafa Emirik   +4 more
wiley   +1 more source

Sulfonamide‐Based 2‐Amino‐1,3,4‐Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT In this study, 12 novel sulfonamide derivatives incorporating 2‐amino‐1,3,4‐oxadiazole and 1,3‐benzazol‐2(3H)‐one scaffolds were synthesized and structurally characterized using 1H NMR, 13C NMR, and LC–MS analyses. Their inhibitory activities were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase I
Gülnur Arslan Karahan, Başak Gökçe, Muhammed Tilahun Muhammed, Emre Kadir Ayan, Azime Berna Özçelik   +4 more
wiley   +1 more source

A hybrid high activity aware framework integrating graph attention network and transformer for half maximal inhibitory concentration prediction. [PDF]

Front Immunol
Ban D, Pan L, Zhang X, Xu P, Wang B, Liu T, Pan D, Li X.   +7 more
europepmc   +1 more source