Results 201 to 210 of about 2,447,781 (239)

Synthesis, Characterization, and Biological Assessment of 2‐Methoxynicotinonitrile Derivatives

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
We report the synthesis of new 2‐methoxy‐3‐cyanopyridine derivatives via the nucleophilic aromatic substitution pathway, along with their crystal structure determination and preliminary biological evaluation. The new synthetic conversion described here demonstrates a practical method of preparing structurally diverse 2‐methoxy‐3‐cyanopyridines and ...
Eman Sulaiman, Eman Al‐Masri, Maram B. Alhawarri, Mohammad M. Ibrahim, Mahmoud Al‐Refai, Basem F. Ali, Ali Shuaib   +6 more
wiley   +1 more source

Molecular insights into kaempferol derivatives as potential inhibitors for CDK2 in colon cancer: pharmacophore modeling, docking, and dynamic analysis. [PDF]

Front Chem
Xing F, Wang Z, Bahadar N, Wang C, Wang XD.   +4 more
europepmc   +1 more source

Design, Synthesis, and Antifungal Activity of Natural Furan Carboxylic Acid Derivatives as Potential Succinate Dehydrogenase Inhibitors

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A series of furanamide derivatives were designed and synthesized. Among these compounds, those containing the trifluoromethyl (─CF3) group exhibited the most potent antifungal activity. Notably, compounds 3m and 6b showed particularly strong effects, and their mechanism of action was further investigated.
Hongxin Luo, Yusen Wang, Yanchang Shi, Chengna Dong, Yadong Song, Qilin Zhang, Zhiqiang Hu, Yukun Qin   +7 more
wiley   +1 more source

Identification of phytomolecules as isoform and mutation specific PI3K-α inhibitor for protection against breast cancer using e-pharmacophore modeling and molecular dynamics simulations. [PDF]

BMC Chem
Mili A, Birangal S, Giridhar J, Nandakumar K, Lobo R.   +4 more
europepmc   +1 more source

Development of Dithioacetal‐Modified Dihydropyrimidone Derivatives with Potential Anti‐Inflammatory Activity for Inflammatory Bowel Disease

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This study designed and synthesized dithioacetal‐modified dihydropyrimidinone derivatives (30). Compound D3 showed optimal anti‐inflammatory activity, inhibiting the MAPK/NF‐κB pathway, reducing NO secretion (IC50 = 1.2 µM), and ameliorating DSS‐induced acute colitis in mice, offering a new candidate for inflammatory bowel disease therapy.
Jian‐Wei Jiang, Rui Dong, Qi Cao, Huan Wang, Si‐Yu Li, Guo‐Ping Zhang, Qian‐Yi Wang   +6 more
wiley   +1 more source

Investigation of Newly Synthesized Fluorinated Isatin-Hydrazones by In Vitro Antiproliferative Activity, Molecular Docking, ADME Analysis, and e-Pharmacophore Modeling. [PDF]

ACS Omega
Başaran E, Köprü S, Akkoç S, Türkmenoğlu B.   +3 more
europepmc   +1 more source

Free Phenolic Hydroxyl Groups Govern the Anticancer Activity of α‐Mangostin: A Structure–Activity Relationship Insight

ChemFoodChem, Volume 2, Issue 3, September 2026.
Free phenolic hydroxyl groups in the chemical structure of the natural xanthone α‐mangostin (MGT) contribute positively to achieving the anticancer profile against murine colon cancer, murine triple negative breast cancer, and human osteosarcoma cancer. ABSTRACT The α‐mangostin (MGT) is a natural xanthone obtained from the pericarp of mangosteen fruit (
Otávio Augusto Chaves, Afonso Santine M. M. Velez, Lívia Stenico, Douglas Chaves de Alcântara Pinto, Debora Decote‐Ricardo, Eliezer Avila Gandra, Marco Edilson Freire de Lima, Carlos Serpa   +7 more
wiley   +1 more source

Combination of Autodisplay and Dynamic Pharmacophore Modeling Reveals New Insights into Cyclic Nucleotide Binding in Hyperpolarization-Activated and Cyclic Nucleotide-Gated Ion Channel 4 (HCN4). [PDF]

ACS Pharmacol Transl Sci
Wojciechowski MN, Jokiel J, Kuss H, Bermúdez M, Jose J.   +4 more
europepmc   +1 more source

Sulfonamide‐Based 2‐Amino‐1,3,4‐Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT In this study, 12 novel sulfonamide derivatives incorporating 2‐amino‐1,3,4‐oxadiazole and 1,3‐benzazol‐2(3H)‐one scaffolds were synthesized and structurally characterized using 1H NMR, 13C NMR, and LC–MS analyses. Their inhibitory activities were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase I
Gülnur Arslan Karahan, Başak Gökçe, Muhammed Tilahun Muhammed, Emre Kadir Ayan, Azime Berna Özçelik   +4 more
wiley   +1 more source

Cinnamaldehyde From Cinnamon as a Food‐Derived Bioactive: Phytochemistry, Anticancer Mechanisms, Bioavailability, Nanoformulation and Safety

Food Frontiers, Volume 7, Issue 5, September 2026.
Cinnamaldehyde derived from Cinnamomum species exerts multitarget anticancer effects by promoting oxidative stress, mitochondrial dysfunction, apoptosis, cell‐cycle arrest, autophagy, and epigenetic changes, and by suppressing mitogen‐activated protein kinase (MAPK), phosphoinositide 3‐kinase/protein kinase B/mechanistic target of rapamycin (PI3K/Akt ...
Gervason Moriasi, Sally Kamau, Gulnaz Seitimova, Shynar Zhumagaliyeva, Javad Sharifi‐Rad, William N. Setzer, Daniela Calina   +6 more
wiley   +1 more source