Results 81 to 90 of about 2,447,781 (239)
, 2019 Toll-like receptor 7 (TLR7) is a transmembrane glycoprotein playing very crucial role in the signaling pathways involved in innate immunity and has been demonstrated to be useful in fighting against infectious disease by recognizing viral ssRNA ...
Upendra Nath Dwivedi (7390766) +5 more
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Workflow diagram presenting the ligand based pharmacophore modeling.
, 2018 (A) In the first part of pharmacophore modeling is the building of conformational-database of 23 chemical compounds in MOE (i) to compute confirmations by confirmation import. (ii) Pack the conformational data-base in the MOE commandline.
Rumeza Hanif (5249699) +4 more
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, 2016 Fidele Ntie-Kang,1,2,* Conrad Veranso Simoben,1,2,* Berin Karaman,1 Valery Fuh Ngwa,3 Philip Neville Judson,4 Wolfgang Sippl,1 Luc Meva’a Mbaze5 1Department of Pharmaceutical Chemistry, Martin-Luther University of Halle-Wittenberg, Halle (Saale ...
Simoben CV +6 more
core
, 2023 Dengue fever is a significant public health concern throughout the world, causing an estimated 500,000 hospitalizations and 20,000 deaths each year, despite the lack of effective therapies.
Md. Sanower Hossain (12978107) +10 more
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PLoS ONE, 2014 Hepatitis C virus (HCV) infection is an alarming and growing threat to public health. The present treatment gives limited efficacy and is poorly tolerated, recommending the urgent medical demand for novel therapeutics.
Abdul Wadood +3 more
doaj +1 more source
DrugOn: a fully integrated pharmacophore modeling and structure optimization toolkit
, 2014 During the past years pharmacophore modeling has become one of the key components in computer-aided drug design and generally in modern drug discovery.
Paraskevas Fakourelis +3 more
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Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy
Angewandte Chemie International Edition, EarlyView.Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean +3 more
wiley +1 more source
Structure-based pharmacophore modeling 1. Automated random pharmacophore model generation
, 2023 Pharmacophores are three-dimensional arrangements of molecular features required for biological activity that are often used in virtual screening efforts to prioritize ligands for experimental testing.
Baker, Daniel L. +3 more
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Angewandte Chemie International Edition, EarlyView.The straightforward conversion of alcohols to tertiary or secondary amines employing Nms‐amides in a single operation is described. The transformation features broad functional group tolerance and high stereospecificity, underscoring its utility in the synthesis of isotope‐labeled pharmaceuticals.
Jakub Brześkiewicz +3 more
wiley +1 more source
Screening benzimidazole derivatives for atypical antipsychotic activity
Фармация и фармакология (Пятигорск)The development of innovative antipsychotic drugs is one of the key tasks of modern pharmacology. Due to their unique chemical properties, benzimidazole derivatives demonstrate diverse neuropsychotropic effects, highlighting their high potential as ...
K. Yu. Kalitin +2 more
doaj +1 more source