Results 21 to 30 of about 52,530,193 (113)

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

The topic-prominence parameter [PDF]

, 2013
This article aims to recast the properties of topic-prominent languages and their differences from subject-prominent languages as documented in the functionalist literature into the framework of the Principle-and-Parameter approach.
Xu, Liejiong
core  

Compound Abrus cantoniensis Extract Alleviates AFB1‐Induced Liver Injury by Regulating PI3K‐AKT Pathway and Gut Microbiota/Butyrate Metabolism

Advanced Science, EarlyView.
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu, Ming cheng, Shiqi Zheng, Huixin Liu, Xiaofang Wei, Wenwen Yang, Hongchun Yang, Liuyang Yuan, Li Jiang, Jie Chen, Linglong Zhao, Yanchao Guo, Hongbin Si   +12 more
wiley   +1 more source

NMR as Used in the Russian and Foreign Pharmacopoeias for Quality Control of Medicinal Products [PDF]

, 2022
The ongoing development of the Pharmacopoeia of the Eurasian Economic Union and the current trend for harmonisation of the Russian Pharmacopoeia with the world leading pharmacopoeias suggest the necessity of studying how different pharmacopoeias use ...
N. E. Kuz’mina, S. V. Moiseev, A. I. Luttseva   +2 more
core   +1 more source

Xylose Acetals ‐ a New Class of Sustainable Solvents and Their Application in Enzymatic Polycondensation

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Novel organic solvents with an unmodified carbohydrate core were synthesised both from D‐xylose and directly from biomass and were successfully used as reaction media for lipase biocatalysts to synthesise aliphatic and aromatic polyesters. Abstract The use of organic solvents in academic research and industry applications is facing increasing ...
Anastasia O. Komarova, Cicely M. Warne, Hugo Pétremand, Laura König‐Mattern, Johannes Stöckelmaier, Chris Oostenbrink, Georg M. Guebitz, Jeremy Luterbacher, Alessandro Pellis   +8 more
wiley   +1 more source

Efforts to Prevent the Neglect of Traditional Indigenous Medicine: Policy Insights From Bolivia

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Traditional Indigenous medicine has existed for centuries, but only recently has it obtained international recognition. Some countries have been working on the integration of traditional Indigenous healing practices in their national health systems.
Carlos Rosas‐Jiménez, Roberto Tola, Melina Flores, Sonia Cruz, Gonzalo Huanca, Cynthia Lokker, Bonny Ibhawoh, Lisa Schwartz   +7 more
wiley   +1 more source

Bridging Worlds: Can Evidence, Regulation and Indigenous Leadership Shape the Future of Traditional, Complementary and Integrative Medicine?

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Background and need As the WHO Global Traditional Medicine Strategy 2025–2034 encourages countries to consider integrating traditional, complementary and integrative medicine (TCIM) into health systems, there is a need to clarify the principal scientific, regulatory, ethical, and governance challenges involved. Renewed global attention to TCIM,
Abdul‐Basit Abdul‐Samed, Dina Balabanova, Neil Spicer, Martin McKee   +3 more
wiley   +1 more source

Spatiotemporal Pattern Evolution and Driving Mechanisms of World Botanical Gardens Over Five Centuries

Integrative Conservation, EarlyView.
This study presents a comprehensive review of the 500‐year spatiotemporal evolution of global botanical gardens, identifying three major development stages—initial exploration (1543–1699), steady expansion (1700–1899), and rapid proliferation (1900–2020)—with six distinct sub‐stages. We propose a tripartite driving framework grounded in colonial botany
Shidong Li, Guangzhen Shi, Qingwei Li
wiley   +1 more source

Production of recombinant human granulocyte‐macrophage colony‐stimulating factor in thermoinducible E. coli: Tuning inclusion body architecture and protein yield via dissolved oxygen control

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Recombinant protein expression in Escherichia coli frequently results in the formation of inclusion bodies (IBs), which provide high protein accumulation but often require additional steps to recover functional protein. Although culture conditions strongly influence IB physicochemical and structural characteristics, the impact of ...
Ximena Gómez‐Gil, Norma A Valdez‐Cruz, Sara Restrepo‐Pineda, Nuria Sánchez‐Puig, Rafael Vázquez‐Duhalt, Rubén D Cadena‐Nava, Néstor O Pérez, Mauricio A Trujillo‐Roldán   +7 more
wiley   +1 more source

Large language models unlock large text corpora in the search for data on medicinal plants and fungi

PLANTS, PEOPLE, PLANET, EarlyView.
Millions of people worldwide depend on plants and fungi for their healthcare needs, yet our understanding of which species are used medicinally—and how—remains fragmented and incomplete. As part of Kew's Plants for Health service, we developed a pipeline to mine large text corpora for information on natural products, initially focusing on the medicinal
Adam Richard‐Bollans, Francesco Civita, Tiziana A. Cossu, Ifra Saifi, Kristina Patmore, Caroline Wilkinson, Bob Allkin   +6 more
wiley   +1 more source