Results 131 to 140 of about 170,196 (315)

A Survival Epidemiology Framework for Oral and Oropharyngeal Cancer

Cancer Nexus, EarlyView.
ABSTRACT Oral and oropharyngeal cancer remains a major global public health burden, but the literature addressing this disease is still organized predominantly around who develops it rather than around what determines life after diagnosis. That imbalance is consequential because diagnosis initiates a new scientific problem.
Raphael E. Cuomo
wiley   +1 more source

Angiotensin II/Angiotensin I Ratio as a New Pharmacodynamic Parameter for Population Modelling in Healthy Adults and Children with Heart Failure Treated with Enalapril

Pharmaceutics
Background/Objectives: Since 2023, enalapril orodispersible minitablets have been approved in Europe for paediatric heart failure from birth, but no population pharmacodynamic analyses have yet been conducted in this patient group. The objectives were to
Melina Steichert, Willi Cawello, Bjoern B. Burckhardt, Fabian K. Suessenbach, Stephanie Laeer, on behalf of the LENA Consortium   +5 more
doaj   +1 more source

The future of pharmacotherapy for obsessive–compulsive disorder may lie in a better understanding of its heterogeneity

, 2014
Pharmacological treatments currently available to treat obsessive-compulsive disorder (OCD) rarely produce remission. This Editorial aims to encourage more targeted research based on the specific OCD symptoms patients primarily present with. Specific OCD
Vlasios Brakoulias, Brakoulias, Vlasios (R19651)   +1 more
core   +1 more source

AI‐Enabled Precision Dosing in Pediatrics: Enhancing Model‐Informed Decision Making

Clinical Pharmacology &Therapeutics, EarlyView.
Ensuring safe and effective pharmacotherapy for children remains a central challenge in clinical pharmacology, yet rapid advances in AI have not translated into clinical practice. This Perspective highlights how AI‐enabled approaches can enhance model‐informed decision making for precision dosing.
Kei Irie, Tomoyuki Mizuno
wiley   +1 more source

Treatment Patterns and Outcomes of Patients With Myelodysplastic Syndrome (MDS) by IPSS-R Scores at Academic Cancer Centers

Advances in Hematology
This study describes treatment patterns and clinical and economic outcomes of patients with myelodysplastic syndrome (MDS) by Revised International Prognostic Scoring System (IPSS-R) risk scores.
Connor Willis, Andre Hejazi, Vonetta L. Williams, Craig Comperatore, Srinivas Tantravahi, Najla Al Ali, Jeffrey Gilreath, Tibor Kovacsovics, Trang Au, Malinda Tan, Madeline Brendle, Rami Komrokji, Minkyoung Yoo, Mushtaq Ashraf, Aamir Khakwani, Şerban R. Iorga, Islam Sadek, David A. Sallman, David Stenehjem   +18 more
doaj   +1 more source

The Pharmacologic management of Attention-deficit hyperactivity disorder

, 2023
The main subject of the following thesis is the pharmacotherapy of Attention-deficit hyperactivity disorder. Prior to delving into the main subject, an introduction to the key aspects of this disorder is discussed, such as symptoms, diagnostic criteria ...
Arnfinnsdóttir, Anna Katín
core  

Biomarker‐Based Prediction of OATP1B1 Activity in Clinical Routine—Investigating Coproporphyrins as Markers for Drug–Drug–Gene Interactions

Clinical Pharmacology &Therapeutics, EarlyView.
Coproporphyrin I (CPI) is an established endogenous biomarker for detecting drug–drug interactions (DDIs) involving the hepatic uptake transporter Organic Anion Transporting Polypeptide 1B1 (OATP1B1, gene SLCO1B1). While CPI has been extensively studied in healthy volunteers using controlled pre‐ and post‐OATP1B1‐inhibitor sampling, its applicability ...
Leila Potzel, Anina Zumtaugwald, Anna Bollinger, Chiara Jeiziner, Kurt E. Hersberger, Florine Wiss, Markus L. Lampert, Samuel S. Allemann, Henriette E. Meyer zu Schwabedissen, Céline K. Stäuble   +9 more
wiley   +1 more source

Improving pharmacotherapy after myocardial infarction by group academic detailing using feedback data on a patient level

, 2006
STUDY OBJECTIVE: To develop and evaluate a peer review group (PRG) meeting using feedback data on a patient level to improve the quality of drug therapy for prevention of recurrent myocardial infarction. DESIGN: Prospective follow-up study.
Bouvy, Marcel L, van der Elst, Menno E, de Blaey, Cornelis J, de Boer, Anthonius   +3 more
core  

Pharmacotherapy of ovarian hyperstimulation syndrome.

, 2010
IMPORTANCE OF THE FIELD: One of the main objectives in assisted reproduction techiques (ART) is the maturation of multiple follicles and the recovery of multiple good quality oocytes.
Patrizia Monteleone, GENAZZANI, ANDREA, Andrea Riccardo Genazzani, Francesca Papini, Monteleone P., ARTINI, PAOLO GIOVANNI, Papini F., Paolo Giovanni Artini   +7 more
core   +1 more source

Impact of CYP2C19 and CYP3A4 Inhibitor Use on Clopidogrel Clinical Effectiveness in CYP2C19 Genotyped Patients Undergoing Percutaneous Coronary Intervention

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2C19 and CYP3A4 contribute to clopidogrel bioactivation. CYP2C19 no‐function alleles diminish clopidogrel's antiplatelet effects and clinical effectiveness. Coadministration of either a CYP2C19 or a CYP3A4 inhibitor may also reduce clopidogrel's antiplatelet effects and lead to phenoconversion in patients without a CYP2C19 no‐function allele (normal/
Danwei Shao, Jean G. Malavé, Joseph S. Rossi, Francesco Franchi, Ellen C. Keeley, Dominick J. Angiolillo, George A. Stouffer, Larisa H. Cavallari, Craig R. Lee   +8 more
wiley   +1 more source