Results 111 to 120 of about 170,196 (315)

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

Attitudes of psychotherapists towards pharmacotherapy in the course of psychotherapy

, 2017
Background: In contrast to the reality of clinical practice, in which psychotherapy and pharmacotherapy are frequently combined, the attitudes of psychotherapists towards the use of pharmacotherapy in conjunction with psychotherapy have to date been ...
Anna Król-Kuczkowska, Marcin Jacek Jabłoński, Krystyna Sosnowska, Renata Moraczewska, Sławomir Murawiec, Wojciech Datka   +5 more
core   +1 more source

Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa, Hayato Shimazaki, Shunji Igarashi, Yoshiki Tagawa, Naoki Hisada, Hiromi Shibasaki   +5 more
wiley   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Cellular electrophysiological effects of the citrus flavonoid hesperetin in dog and rabbit cardiac ventricular preparations

Scientific Reports
Recent experimental data shows that hesperetin, a citrus flavonoid, affects potassium channels and can prolong the QTc interval in humans. Therefore, in the present study we investigated the effects of hesperetin on various transmembrane ionic currents ...
Aiman Saleh A. Mohammed, Gábor Mohácsi, Muhammad Naveed, János Prorok, Norbert Jost, László Virág, István Baczkó, Leila Topal, András Varró   +8 more
doaj   +1 more source

A scoping review of quality prescribing indicators, rules and criteria for primary care

British Journal of Clinical Pharmacology, EarlyView.
Medication‐related problems (MRPs) place a substantial burden on the healthcare system, contributing to hospital admissions and significant healthcare costs. Quality prescribing indicators (QPIs), rules and criteria serve to educate prescribers about high risk MRPs and to monitor prescribing behaviours. This study aims to summarize existing indicators,
James Nind, Anna Mackintosh, Emma Maddock, Alana Delaforce, Gregory Peterson, Elizabeth Manias, Johnson George   +6 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Pharmacotherapy of osteoporosis.

Folia Pharmacologica Japonica, 2002
Osteoporosis with increased risk of bone fracture is a disabling syndrome that naturally occurs as long as one ages and moves on two legs. Recent progress in bone cell biology has shed light on the mechanisms underlying the anti-osteoporotic properties of drugs that have been in use for a long time, providing a fresh stage for novel pharmacotherapies ...
openaire   +3 more sources

New pharmacological agents and novel cardiovascular pharmacotherapy strategies in 2024. [PDF]

Despite substantial advances in cardiovascular pharmacotherapy and devices in recent years, prevention and treatment of many cardiovascular diseases (CVD) remain limited, thus reflecting the need for more effective and safer pharmacological strategies ...
Grove, Erik Lerkevang, Tamargo, Juan, Semb, A.G., Klingenberg, Roland, Agewall, S., Grove, EL, Klingenberg, R, Ambrosio, G., Drexel, Heinz, Agewall, S, Semb, Anne Grete, Cerbai, Elisabetta, Morais, J., Sossalla, S, Sossalla, Samuel, Ambrosio, Giuseppe, Grove, E.L., Kaski, JC, Ambrosio, G, Sulzgruber, P., Cerbai, E, Tamargo, J., Drexel, H., Parker, William, Drexel, H, Agewall, Stefan, Rocca, B, Ferdinandy, P, Dobrev, Dobromir, Sossalla, S., Klingenberg, R., Cerbai, E., Dan, Gheorghe A, Rocca, B., Tamargo, J, Parker, W, Morais, J, Dobrev, D., Morais, João, Dan, G.A., Dobrev, D, Kaski, J.C., Sulzgruber, P, Dan, GA, Borghi, Claudio, Semb, AG, Parker, W., Borghi, C., Borghi, C, Ferdinandy, Péter, Sulzgruber, Patrick, Kaski, Juan Carlos, Ferdinandy, P., Rocca, Bianca   +53 more
core   +1 more source

Pharmacogenomic profiling of the efficacy of gemcitabine monotherapy in metastatic pancreatic cancer: Subgroup analysis of the GENESECT study

British Journal of Clinical Pharmacology, EarlyView.
Aim In the GENESECT study, no significant gemcitabine (GEM) metabolism‐related germline genetic polymorphisms (GPs) were identified because approximately 70% of patients received combination therapy with nab‐paclitaxel, which has metabolic pathways different from GEM.
Takashi Yokokawa, Daiki Tsuji, Masahiro Hatori, Kazuyoshi Kawakami, Masahiko Nakao, Takuya Yano, Yuichiro Arakawa, Keisuke Matsuo, Yasukata Ohashi, Masato Ozaka, Naoki Sasahira, Yasuhiko Sakata, Yuki Kogure, Shinya Tamaki, Atsushi Wada, Yusuke Taki, Wataru Suzuki, Kazuo Kobayashi, Hiroshi Ishii, Kunihiko Itoh, Masakazu Yamaguchi, Kenichi Suzuki   +21 more
wiley   +1 more source