Results 21 to 30 of about 27,161 (265)

Hepatitis-related adverse events associated with immune checkpoint inhibitors in cancer patients: an observational, retrospective, pharmacovigilance study using the FAERS database

Frontiers in Pharmacology
Background: Immune checkpoint inhibitors (ICIs), including anti-PD-1, anti-PD-L1 and anti-CTLA-4 antibodies, have become a standard treatment for multiple cancer types.
Zhiwen Fu, Jinmei Liu, Cong Zhang, Huiping Hu, Shijun Li, Yu Zhang, Ruxu You   +6 more
doaj   +1 more source

Assessment of the state of pharmacovigilance in the South-South zone of Nigeria using WHO pharmacovigilance indicators

BMC Pharmacology and Toxicology, 2018
Background WHO pharmacovigilance indicators have been recommended as a useful tool towards improving pharmacovigilance activities. Nigeria with a myriad of medicines related issues is encouraging the growth of pharmacovigilance at peripheral centres ...
Abimbola O. Opadeyi, Annie Fourrier-Réglat, Ambrose O. Isah   +2 more
doaj   +1 more source

A pharmacovigilance study in chest diseases outpatient clinic

Tuberkuloz ve Toraks, 2012
Adverse drug reactions is an important healthcare issue, it causes excess morbidity and mortality. The aim of this study was to determine the adverse drug reactions in patients who admitted to the outpatient clinic of respiratory diseases and to improve some clinical strategies if they are preventable.This study is a prospective observational study ...
Coşkun, Usta, Aykut, Cilli, Burcu, Celenk, Ruşen, Uzun   +3 more
openaire   +2 more sources

Psychiatric events induced by roflumilast: a real-world pharmacovigilance study of the FDA Adverse Event Reporting System database

Frontiers in Psychiatry
BackgroundRoflumilast has approved treatment in patients with chronic obstructive pulmonary disease. The post-marketing data concerning roflumilast remain limited, and the outcomes of relevant studies are yet to yield conclusive evidence supporting the ...
Lifang Wu, Yan Chen, Yaping Huang, Shaojun Jiang, Shaojun Jiang, Chengjie Ke, Chengjie Ke   +6 more
doaj   +1 more source

An analytical quantification clinical research, and an observational descriptive qualitative pharmacological research analysis on pharmacovigilance assessments of metformin monotherapy and combination therapies: A mixed-method study

National Journal of Physiology, Pharmacy and Pharmacology, 2022
Background: The anti-diabetic mono- as well as combination pharmacotherapy with metformin, for the routine healthcare treatment of type II diabetic patients, is sufficiently efficacious, with an adequately safe glycemic stabilization rate.
Moumita Hazra
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Associations between intercurrent events and cardiorenal clinical outcomes in non-diabetic chronic kidney disease: a real-world retrospective cohort study in the United States

BMC Nephrology
Background Chronic kidney disease (CKD) is a global public health concern, with 50–70% of the burden attributed to non-diabetic aetiology. To expand CKD research, there is a need to identify novel surrogate endpoints preceding cardiorenal outcomes that ...
Christoph Wanner, Johannes Schuchhardt, Chris Bauer, Meike Brinker, Frank Kleinjung, Tatsiana Vaitsiakhovich   +5 more
doaj   +1 more source

Losartan: a study of pharmacovigilance data on 14 522 patients [PDF]

Journal of Human Hypertension, 1999
The objective of this study was to undertake a post- marketing safety surveillance study of losartan, the first specific angiotensin-II receptor antagonist to be marketed in England. It is a non-interventional observational cohort study using the technique of prescription-event monitoring.
R, Mann, F, Mackay, G, Pearce, S, Freemantle, L, Wilton   +4 more
openaire   +2 more sources

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source

Immune Checkpoint Inhibitor–Related Myositis and Associated Triad Overlap Syndrome

Arthritis Care &Research, EarlyView.
Objective Immune checkpoint inhibitor (ICI) myositis is a rare but a highly morbid condition, particularly with the ICI myositis triad syndrome of myositis, myocarditis, and myasthenia gravis. We report the clinical characteristics of ICI myositis and all‐cause mortality in these patients.
Selene Rubino, Grant W. Cannon, Brian C. Sauer, Jorge Rojas, Gregory J. Stoddard, Gary A. Kunkel, Jessica A. Walsh, Bryant R. England, Joshua F. Baker, Tawnie J. Braaten   +9 more
wiley   +1 more source