Results 51 to 60 of about 1,770,976 (403)

Opportunities to encourage mail order pharmacy delivery service use for diabetes prescriptions: a qualitative study. [PDF]

open access: yes, 2019
BackgroundMedication non-adherence is a major contributor to poor outcomes in diabetes. Previous research has shown an association between use of mail order pharmacy delivery and better medication adherence, but little is known about the barriers and ...
Brown, Susan D   +8 more
core  

COVID-19 Pandemic Challenges and Lessons Learned by Pharmacy Educators Around the Globe

open access: yesAmerican Journal of Pharmaceutical Education, 2020
The coronavirus identified in 2019 (COVID-19) has affected peoples’ lives worldwide. This pandemic forced both pharmacy faculty members and students to adapt to a new teaching and learning environment not only in the United States but around the globe ...
Marina Kawaguchi‐Suzuki   +3 more
semanticscholar   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

open access: yesFEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

open access: yesFEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Comparison of the antioxidant effect and phenolic profile of two Crataegus extracts

open access: yesMedicine Science, 2020
This study was designed to evaluate the phenolic profiles and antioxidant potentials of two commercial Crataegus monogyna Jacq samples, which are commonly used for various medicinal purposes.
Hilal Bardakci   +4 more
doaj   +1 more source

Integrating community pharmacy and NHS Direct - pharmacists' views [PDF]

open access: yes, 2002
AIM:To establish the views of community pharmacists on NHS Direct and its forthcoming integration with community pharmacy. DESIGN: Postal questionnaire survey. SUBJECTS AND SETTING: Pharmacists working in community pharmacies within the area of the
Knowles, E.   +3 more
core  

Practice, Skill Mix, and Education: The Evolving Role of Pharmacy Technicians in Great Britain [PDF]

open access: yes, 2020
Pharmacy technicians’ roles are rapidly evolving in Great Britain (GB) as they undertake more extended activities with increased autonomy across the different pharmacy sectors.
Boughen, Melanie, Fenn, Tess
core   +1 more source

Pharmacy and Medical Students’ Mental Health Symptoms, Experiences, Attitudes and Help-Seeking Behaviors

open access: yesAmerican Journal of Pharmaceutical Education, 2019
Objective. To examine and compare the prevalence of mental health problems, help-seeking attitudes, and perceptions about mental health problems among US pharmacy and medical students. Methods.
R. Fischbein, Natalie Bonfine
semanticscholar   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

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