Results 121 to 130 of about 768,945 (215)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Light does not phase shift the circadian clock of subcutaneous adipose tissue in vitro. [PDF]

NPJ Biol Timing Sleep
Edmondson A, Beresford C, Harmsen JF.
europepmc   +1 more source

Impact of Time-Restricted Feeding on Adaptation to a 6-Hour Delay Phase Shift or a 12-Hour Phase Shift in Mice. [PDF]

Nutrients, 2022
Ren B, Huang Y, Zhang J, Li J, Liu Z, Guan Y, Chen L, Yang G.   +7 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

El Niño-driven phase shift to algal dominance on Isla del Caño's coral reefs: implications for urgent restoration. [PDF]

PeerJ
Palmer CV, Rodríguez Esquivel SV, Parker CM.   +2 more
europepmc   +1 more source

Phase shift between joint rotation and actuation reflects dominant forces and predicts muscle activation patterns. [PDF]

PNAS Nexus, 2023
Sutton GP, Szczecinski NS, Quinn RD, Chiel HJ.   +3 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Optical and Acoustic Characterization of Phase-Shift Droplets with Varying Shell Compositions. [PDF]

Langmuir
Chaudhary S, Kaushik A, Abeid BA, Estrada JB, Fabiilli ML, Aliabouzar M.   +5 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Heterogeneous-IRS-Assisted Millimeter-Wave Systems: Element Position and Phase Shift Optimization. [PDF]

Sensors (Basel)
Zhao W, Wu Q, Wei H, Su D, Zhu Y.
europepmc   +1 more source