Results 141 to 150 of about 941,423 (318)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Influence of Magnetic Saturation of Iron-Core on Performance of Thyristor Phase Control Circuit
, 1982 The influence of magnetic saturation of iron-core on the performance of thyristor phase control circuit with series RLC elements is described. The circuit is analyzed by applying an approximate model of three straight lines to the flux Φ vs.
Nakanishi, Sen-ichiro +2 more
core +1 more source
Research on the possibility of reducing the error in measuring the phase shift of radio signals
Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie ŚrodowiskaThe possibility of reducing the error in measuring the phase shift of radio signals by the orthogonal method using analogue quadrature demodulators in solving scientific and technical problems in energy, non-destructive testing, research on determining ...
Sergey Matvienko +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
A digital dithering phase shift modulator for enhanced resolution
This article proposes a digital dithering phase shift modulator to control power electronic converters. The presented modulator allows a higher resolution for digitally generated phase-shift signals without the need for fine time steps using very high ...
Ulrich, Burkhard
core +1 more source
VSC transmission system using flying capacitor multilevel converters and hybrid PWM control
, 2007 A high-voltage direct current (HVDC) transmission system based on three-level flying capacitor (FC) multilevel converters with hybrid pulse-width modulation (PWM) is presented in this paper.
Agelidis, V.G., Xu, L.
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
IET Power ElectronicsThe study proposes an advanced control technique for modular‐structured series‐resonant converters, unifying pulse‐density modulation (PDM) and phase‐shift control to mitigate output current amplitude fluctuations.
Pavlo Herasymenko +3 more
doaj +1 more source