Results 121 to 130 of about 941,423 (318)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Vectorial Approach for Generation of Optimal Current References for Multiphase Permanent-Magnet Synchronous Machines in Real Time [PDF]

, 2011
This paper deals with the generation of optimal current references for multiphase permanent-magnet (PM) synchronous machines in normal or fault mode (open-circuited phases).
KESTELYN, Xavier, SEMAIL, Eric, Eric Semail, Xavier Kestelyn   +3 more
core   +1 more source

Thermal balancing of multiphase battery chargers controlled by phase shift

Journal of Power Sources
Power sources based on multiphase resonant converters, controlled by phase-shift at constant switching frequency, reduce conduction losses and enable current-mode operation for battery charger applications. However, phase-shift modulation in multiphase class D resonant converters inherently causes uneven current distribution among sections, leading to ...
Brañas Reyes, Christian, Pigazo López, Alberto, Casanueva Arpide, Rosario, Azcondo Sánchez, Francisco Javier, Díaz Rodríguez, Francisco Javier, Lamo Anuarbe, Paula   +5 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Optimal control strategy of dual active bridge DC-DC converter with combined dual-phase-shift and traditional-phase-shift controls

, 2016
In order to reduce the power losses of the dual active bridge (DAB) DC-DC converter, an optimal control strategy combining dual-phase-shift and traditional-phase-shift controls is proposed.
Wu, J, Shen, Y, Meng, D, Shen, H, ,, Sun, X   +5 more
core  

Controlling response shift bias: The use of the retrospective pre-test design in the evaluation of a master's programme

, 2012
Student self-report measures of change are widely used in evaluation research to measure the impact and outcomes of an educational programme or intervention. Traditionally the measures used to evaluate the impact of an educational programme on student
Hyde, Abbey, Drennan, Jonathan
core   +1 more source

Current Stress Optimization in Buck-Boost Mode Based on New Extended Phase-Shift Dual Active Full-Bridge Converter

Shanghai Jiaotong Daxue xuebao
To reduce the current stress of dual active full-bridge converters in the buck-boost mode, a current stress optimization control strategy based on new extended-phase-shift modulation is proposed.
TAO Haijun, WANG Hongyi, YANG Naitong
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Ripple elimination for DC/AC DAB converter with phase shift and duty cycle control

, 2016
Active ripple current reduction method is proposed for isolated DC/AC dual active bridge (DAB) converter to reduce the double grid frequency ripple in the DC current.
W. L. Malan, You, Jiang, Ghasemi, N., Vilathgamuwa, D. M., Jiang You, Malan, W. L., D. M. Vilathgamuwa, N. Ghasemi   +7 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source