Results 101 to 110 of about 941,423 (318)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

An Improved AC-Link Voltage Matching Control for the Multiport Modular Multilevel DC Transformer in MVDC Applications

Energies
In this paper, an improved AC-link voltage matching control (IVM) strategy is proposed for the multiport modular multilevel DC transformer (M3DCT), which comprises a single-phase modular multilevel converter (MMC) and a series of cascaded H-bridge units.
Yong Chen, Songtao Yu, Yizhen Wang, Ruixiong Yang, Xu Cheng   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Direct control strategy for a four-level three-phase flying-capacitor inverter [PDF]

, 2010
A direct predictive control strategy is proposed for a three-phase four-level flying-capacitor (FC) inverter in this paper. The balancing of the FC voltages, a challenge in applications with small capacitors and low switching frequencies, is done without
Llor, Ana-Maria, Fadel, Maurice, Defaÿ, François   +2 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Bidirectional charger control strategy for low-voltage charging based on DAB circuit

机车电传动
The dual active bridge bidirectional battery charger (DAB-BBC) is a critical device for railway trains to achieve emergency traction functionality. Single-Phase Shift (SPS) control is widely employed in DAB-BBC circuits due to its advantages such as ...
WU Liangui, DOU Zechun, ZHOU Shuai, ZHANG Xiaoyong, ZHOU Fengwu, LIAO Renbiao   +5 more
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Iterative learning control: algorithm development and experimental benchmarking

, 2009
This thesis concerns the general area of experimental benchmarking of Iterative Learning Control (ILC) algorithms using two experimental facilities. ILC is an approach which is suitable for applications where the same task is executed repeatedly over the
Cai, Zhonglun
core  

A millimetre wave phase shifter using a 40GHz hybrid mode locked laser [PDF]

, 2008
In this paper, electrical injection locking of a modelocked laser is used to create a millimetre wave phase shifter. The phase shift is measured directly using a vector network analyzer enabling straightforward characterization of such systems.
Martin J. Cryan, Cryan, MJ, Khawaja, BAM, Bilal A. Khawaja   +3 more
core   +1 more source