Results 151 to 160 of about 11,382,550 (291)

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Symmetry-Imposed Selection Rules for Excitations of Nontrivial Plasmonic Topologies. [PDF]

Adv Sci (Weinh)
Yang J, Feng P, Han F, Chen W, Jin Z, Ni J, Yang Y, Zhang A, Vandenbosch GAE, Verellen N, Janssens E, Wang J, Bai B, Qiu CW, Zheng X.   +14 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Adaptive Trial Designs for Assessing Predictiveness of a Biomarker in Early Phase Drug Development. [PDF]

Stat Med
Daniells L, Geronimi J, Hadjur H, Guilleminot S, Mozgunov P.   +4 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Seamless Phase I-II Cancer Clinical Trials Using Kernel-Based Covariate Similarity. [PDF]

Pharm Stat
Makino K, Makigusa N, Kojima M.
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Lévy Formulation of the Stochastic Theory of Chromatography and Extension to Phase-Type Markov Renewal Process. [PDF]

Anal Chem
Mirzahosseini A, Sepsey A, Tóth G, Felinger A.   +3 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Cell Population Dynamics Informed by Cell-Cycle Regulation: A Deterministic Modeling Toolkit. [PDF]

Comput Struct Biotechnol J
Ferro E, Laus A, Atzeni R, Valentini M, Pieroni E, Pisu M.   +5 more
europepmc   +1 more source